U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C15H15FN4O.ClH
Molecular Weight 322.765
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZOLAZEPAM HYDROCHLORIDE

SMILES

Cl.CN1N=C(C)C2=C1N(C)C(=O)CN=C2C3=CC=CC=C3F

InChI

InChIKey=NJERAXSSDSHLGE-UHFFFAOYSA-N
InChI=1S/C15H15FN4O.ClH/c1-9-13-14(10-6-4-5-7-11(10)16)17-8-12(21)19(2)15(13)20(3)18-9;/h4-7H,8H2,1-3H3;1H

HIDE SMILES / InChI
Zolazepam is used as an anaesthetic in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine. This combination is indicated in cats for restraint or for anesthesia combined with muscle relaxation and in dogs for restraint and minor procedures of short duration requiring mild to moderate analgesia. Used alone, tiletamine does not provide adequate muscle relaxation for abdominal surgical procedures. When combined with zolazepam hydrochloride, good muscle relaxation is generally attained during the phase of deep surgical anesthesia.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
TELAZOL

Approved Use

Unknown
Doses

Doses

DosePopulationAdverse events​
100 mg single, intravenous
Abused dose
Dose: 100 mg
Route: intravenous
Route: single
Dose: 100 mg
Sources:
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
Disc. AE: Syncopal attack...
AEs leading to
discontinuation/dose reduction:
Syncopal attack
Sources:
1125 mg single, intravenous
Abused dose
Dose: 1125 mg
Route: intravenous
Route: single
Dose: 1125 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
Disc. AE: Tremor, Lethargy...
AEs leading to
discontinuation/dose reduction:
Tremor
Lethargy
Vision blurred
Salivation
Chills
Fatigue
Sources:
875 mg single, oral
Abused dose
Dose: 875 mg
Route: oral
Route: single
Dose: 875 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
Disc. AE: Stupor, Hypertension...
AEs leading to
discontinuation/dose reduction:
Stupor
Hypertension
Bradycardia
Mental confusion
Sources:
AEs

AEs

AESignificanceDosePopulation
Syncopal attack Disc. AE
100 mg single, intravenous
Abused dose
Dose: 100 mg
Route: intravenous
Route: single
Dose: 100 mg
Sources:
healthy, ADULT
Health Status: healthy
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
Chills Disc. AE
1125 mg single, intravenous
Abused dose
Dose: 1125 mg
Route: intravenous
Route: single
Dose: 1125 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
Fatigue Disc. AE
1125 mg single, intravenous
Abused dose
Dose: 1125 mg
Route: intravenous
Route: single
Dose: 1125 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
Lethargy Disc. AE
1125 mg single, intravenous
Abused dose
Dose: 1125 mg
Route: intravenous
Route: single
Dose: 1125 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
Salivation Disc. AE
1125 mg single, intravenous
Abused dose
Dose: 1125 mg
Route: intravenous
Route: single
Dose: 1125 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
Tremor Disc. AE
1125 mg single, intravenous
Abused dose
Dose: 1125 mg
Route: intravenous
Route: single
Dose: 1125 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
Vision blurred Disc. AE
1125 mg single, intravenous
Abused dose
Dose: 1125 mg
Route: intravenous
Route: single
Dose: 1125 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: M
Food Status: UNKNOWN
Sources:
Bradycardia Disc. AE
875 mg single, oral
Abused dose
Dose: 875 mg
Route: oral
Route: single
Dose: 875 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
Hypertension Disc. AE
875 mg single, oral
Abused dose
Dose: 875 mg
Route: oral
Route: single
Dose: 875 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
Mental confusion Disc. AE
875 mg single, oral
Abused dose
Dose: 875 mg
Route: oral
Route: single
Dose: 875 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
Stupor Disc. AE
875 mg single, oral
Abused dose
Dose: 875 mg
Route: oral
Route: single
Dose: 875 mg
Sources:
unknown, ADULT
Health Status: unknown
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Sources:
PubMed

PubMed

TitleDatePubMed
Evaluation of anesthetic protocol for the collection of semen from captive collared peccaries (Tayassu tajacu) by electroejaculation.
2009-12
Effects of different general anesthetics on serum hemolysis and hepatic and muscular glycogenolysis in rats.
2009-11
The effect of amnion-derived cellular cytokine solution on the epithelialization of partial-thickness donor site wounds in normal and streptozotocin-induced diabetic swine.
2009-10-20
Movement disorder caused by abuse of veterinary anesthesia containing tiletamine.
2009-10
A serological survey of infectious disease in Yellowstone National Park's canid community.
2009-09-16
Efficacy of strain RB51 vaccine in protecting infection and vertical transmission against Brucella abortus in Sprague-Dawley rats.
2009-09
Evaluation of three immobilization combinations in the capybara (Hydrochoerus hydrochaeris).
2009-08-01
In vivo properties of the proangiogenic peptide QK.
2009-06-08
The effects of different anesthetic agents on short electroretinography protocol in dogs.
2009-06
Imaging evaluation of the liver using multi-detector row computed tomography in micropigs as potential living liver donors.
2009-06
Use of two anesthetic combinations for semen collection by electroejaculation from captive coatis (Nasua nasua).
2009-05
A pig model of acute Staphylococcus aureus induced pyemia.
2009-03-27
Comparison of azaperone-detomidine-butorphanol-ketamine and azaperone-tiletamine-zolazepam for anaesthesia in piglets.
2009-03
Biliary clearance of bromosulfophthalein in anesthetized and freely moving conscious rat.
2009-03
Urinary cortisol responses to unusual events in captive chimpanzees (Pan troglodytes).
2009-01
Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta.
2009-01
A recruitment breath manoeuvre directly after endotracheal suction improves lung function: an experimental study in pigs.
2009
Physiological effects of the TASER C2 conducted energy weapon.
2009
Acute effects of an alternative electronic-control-device waveform in swine.
2009
Reversible immobilization of asiatic black bear (Ursus thibetanus) with detomidine-tiletamine-zolazepam and atipamezole.
2008-12
Effects of premedication with tiletamine/zolazepam/medetomidine during general anesthesia using sevoflurane/fentanyl in swine undergoing pancreas transplantation.
2008-11
Methods of advanced wound management for care of combined traumatic and chemical warfare injuries.
2008-07-21
Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning 1H magnetic resonance spectroscopy.
2008-04-25
Biomedical evaluation of free-ranging red ruffed lemurs (Varecia rubra) within the Masoala National Park, Madagascar.
2008-03
Clinical and pathologic features of cynomolgus macaques (Macaca fascicularis) infected with aerosolized Yersinia pestis.
2008-02
Effects of acepromazine and butorphanol on tiletamine-zolazepam anesthesia in llamas.
2008-02
Effects of two different anaesthetics on serum concentrations of cortisol and luteinizing hormone in barrows and gilts.
2008-01
Changes in minimal alveolar concentration of isoflurane following treatment with medetomidine and tiletamine/zolazepam, epidural morphine or systemic buprenorphine in pigs.
2008-01
Echocardiographic reference ranges for sedated healthy cynomolgus monkeys (Macaca fascicularis).
2008-01
Antagonistic effects of yohimbine in pigs anaesthetised with tiletamine/zolazepam and xylazine.
2007-11-03
Tiletamine-zolazepam and xylazine is a potent cardiodepressive combination: a case report.
2007-11
Nitric oxide and angiotensin II receptors mediate the pressor effect of angiotensin II: a study in conscious and zoletil-anesthetized rats.
2007-11
Serial CT findings of Paragonimus infested dogs and the Micro-CT findings of the worm cysts.
2007-10-10
Cavo-portal transposition in rat: a new simple model.
2007-08-16
Pseudomyxoma peritonei--two novel orthotopic mouse models portray the PMCA-I histopathologic subtype.
2007-06-30
Effects of tiletamine-zolazepam anaesthesia on plasma antioxidative status and some haematological parameters in sheep.
2007-06
Tiletamine-zolazepam-xylazine immobilization of fishers (Martes pennanti).
2007-04
Immobilization of Japanese black bears (Ursus thibetanus japonicus) with tiletamine hydrochloride and zolazepam hydrochloride.
2007-04
Comparison of cardiovascular effects of tiletamine-zolazepam, pentobarbital, and ketamine-xylazine in male rats.
2007-03
A comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol- medetomidine in cats.
2007
Comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol-medetomidine in dogs.
2007
Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus).
2006-12
Reversible anesthesia of Southeast Asian primates with medetomidine, zolazepam, and tiletamine.
2006-12
Pharmacokinetics of tiletamine and zolazepam (Telazol) in anesthetized pigs.
2006-12
Determination of constituents of Telazol--tiletamine and zolazepam by a gas chromatography/mass spectrometry-based method.
2006-10-02
Reversible immobilization of free-ranging African lions (Panthera leo) with medetomidine-tiletamine-zolazepam and atipamezole.
2006-04
Immobilization of free-ranging maned wolf (Chrysocyon brachyurus) with tiletamine and zolazepam in central Brazil.
2006-03
Chemical immobilization of adult female Weddell seals with tiletamine and zolazepam: effects of age, condition and stage of lactation.
2006-02-09
Clinical and cardiorespiratory effects of propofol in the spotted bamboo shark (Chylloscyllium plagiosum).
2005-12
Reversible anaesthesia of free-ranging lions (Panthera leo) in Zimbabwe.
2005-12
Patents

Patents

Sample Use Guides

Dogs: In healthy dogs, an initial intramuscular dosage of 3 to 4.5 mg/lb (6.6 to 9.9 mg/kg) TELAZOL ((tiletamine HCl and zolazepam HCl) is recommended for diagnostic purposes; 4.5 to 6 mg/lb (9.9 to 13.2 mg/kg) for minor procedures of short duration, such as treatment of lacerations and wounds, castrations and other procedures requiring mild to moderate analgesia. When supplemental doses of TELAZOL are required, such individual supplemental doses should be less than the initial dose, and the total dose given (initial dose plus supplemental dose or doses) should not exceed 12 mg/lb (26.4 mg/kg). The maximum safe dose is 13.6 mg/lb (29.92 mg/kg). Cats: In healthy cats, an initial TELAZOL dosage of 4.4 to 5.4 mg/lb (9.7 to 11.9 mg/kg) is recommended for such procedures as dentistry, treatment of abscesses, foreign body removal and related types of surgery; 4.8 to 5.7 mg/lb (10.6 to 12.5 mg/kg) for minor procedures requiring mild to moderate analgesia, such as repair of lacerations, castrations and other procedures of short duration. Initial dosages of 6.5 to 7.2 mg/lb (14.3 to 15.8 mg/kg) are recommended for ovario- hysterectomy and onychectomy. When supplemental doses of TELAZOL are required, such individual supplemental doses should be given in increments that are less than the initial dose, and the total dose given (initial dose plus supplemental doses) should not exceed the maximum allowable safe dose of 32.7 mg/lb (72 mg/kg).
Route of Administration: Intramuscular
In Vitro Use Guide
Unknown
Name Type Language
ZOLAZEPAM HYDROCHLORIDE
GREEN BOOK   MART.   MI   USAN   USP   USP-RS  
USAN  
Official Name English
CI-716
Preferred Name English
ZOLAZEPAM HYDROCHLORIDE [USP-RS]
Common Name English
ZOLAZEPAM HYDROCHLORIDE [USAN]
Common Name English
ZOLAZEPAM HYDROCHLORIDE [MI]
Common Name English
ZOLAZEPAM HYDROCHLORIDE [USP MONOGRAPH]
Common Name English
ZOLAZEPAM HYDROCHLORIDE [USP IMPURITY]
Common Name English
PYRAZOLO(3,4-E)(1,4)DIAZEPIN-7(1H)-ONE, 4-(2-FLUOROPHENYL)-6,8-DIHYDRO-1,3,8-TRIMETHYL-, MONOHYDROCHLORIDE
Common Name English
ZOLAZEPAM HCL
Common Name English
4-(O-Fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo[3,4-E][1,4]diazepin-7(1H)-one monohydrochloride
Common Name English
ZOLAZEPAM HYDROCHLORIDE [GREEN BOOK]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1012
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
CFR 21 CFR 522.2470
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
Code System Code Type Description
CAS
33754-49-3
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
MERCK INDEX
m11657
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY Merck Index
ECHA (EC/EINECS)
251-668-7
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
RS_ITEM_NUM
1724805
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
SMS_ID
300000029174
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
FDA UNII
45SJ093Q1N
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
DRUG BANK
DBSALT001709
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
NCI_THESAURUS
C76953
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
EPA CompTox
DTXSID00955349
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
ChEMBL
CHEMBL2111144
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
DAILYMED
45SJ093Q1N
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
RXCUI
1999183
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY
PUBCHEM
71416
Created by admin on Mon Mar 31 18:14:07 GMT 2025 , Edited by admin on Mon Mar 31 18:14:07 GMT 2025
PRIMARY