Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C23H38O5 |
Molecular Weight | 394.5448 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 2 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCC\C=C\C(=O)OC
InChI
InChIKey=KYBOHGVERHWSSV-VNIVIJDLSA-N
InChI=1S/C23H38O5/c1-5-6-15-23(2,3)21(26)14-13-18-17(19(24)16-20(18)25)11-9-7-8-10-12-22(27)28-4/h10,12-14,17-18,20-21,25-26H,5-9,11,15-16H2,1-4H3/b12-10+,14-13+/t17-,18-,20-,21-/m1/s1
DescriptionSources: https://gp2u.com.au/static/pdf/C/CERVAGEM-PI.pdf
Sources: https://gp2u.com.au/static/pdf/C/CERVAGEM-PI.pdf
Gemeprost is a PGE1 analogue indicated for softening and dilatation of the cervix uteri prior to operative procedures or therapeutic abortion. The drug is marketed under the name Cervagem.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:0070471 Sources: https://www.medicines.org.uk/emc/medicine/3968 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | CERVAGEM Approved UseFor the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy. Therapeutic termination of pregnancy in patients in the second trimester of gestation. Launch Date1990 |
PubMed
Title | Date | PubMed |
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The use of prostaglandin E1 analogue pessaries in patients having first trimester induced abortions. | 1980 Apr |
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Abortifacient effect and uterine cervix-dilating action of 16, 16-dimethyl trans delta 2 PGE1 methyl ester (ONO 802) in the form of a vaginal suppository (a randomized, double-blind, controlled study in the second trimester of pregnancy). | 1982 Sep |
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A Gemeprost vaginal suppository for cervical priming prior to termination of first trimester pregnancy. | 1984 Mar |
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The use of 16,16-dimethyl-trans delta 2 prostaglandin E1 methyl ester (gemeprost) vaginal pessaries for the termination of pregnancy in the early second trimester. A comparison with extra-amniotic prostaglandin E2. | 1984 Nov |
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Midtrimester termination of pregnancy using intravaginal gemeprost (16, 16 dimethyl-trans delta 2 PGE1 methyl ester, cervagem). | 1985 Apr |
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[Use of a new vaginal suppository: prostaglandin E1 analog Gemeprost for cervix maturation prior to abortion in the 1st trimester]. | 1985 Jun |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://gp2u.com.au/static/pdf/C/CERVAGEM-PI.pdf
One pessary to be inserted into the posterior vaginal fornix three hours before surgery.
Route of Administration:
Vaginal
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C78568
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GEMEPROST
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ACTIVE MOIETY