Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H13N3O3 |
Molecular Weight | 295.2927 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C2=C(C=C(C=C2)[N+]([O-])=O)C(=NCC1=O)C3=CC=CC=C3
InChI
InChIKey=GWUSZQUVEVMBPI-UHFFFAOYSA-N
InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
DescriptionCurator's Comment: Description was created based on several sources, including https://www.cnb.gov.sg/drugs/bannedsubstance/nimetazepam.aspx
Curator's Comment: Description was created based on several sources, including https://www.cnb.gov.sg/drugs/bannedsubstance/nimetazepam.aspx
Nimetazepam (Erimin) is an intermediate-acting hypnotic drug which is a benzodiazepine derivative. It was first synthesized in 1962 in Japan. It does possess hypnotic, anxiolytic, sedative, and skeletal muscle relaxant properties. Nimetazepam is also an anticonvulsant. It is sold in 5 mg tablets known as Erimin. It is generally prescribed for the treatment of short-term severe insomnia in patients who have difficulty falling asleep or maintaining sleep. Nimetazepam is currently a Schedule IV drug under the international Convention on Psychotropic Substances of 1971. In Singapore, nimetazepam is a class C drug under the Misuse of Drugs Act. In Hong Kong, nimetazepam is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Nimetazepam can only be used legally by health professionals and for university research purposes.
CNS Activity
Originator
Sources: http://globalpharma.tradekorea.com/product/detail/P511072/Nimetazepam%20&%20Erimin%205.html?minisiteprodgroupno=
Curator's Comment: First synthesized by a team at Hoffmann-La Roche in 1962 # Hoffmann-La Roche
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2096683 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2857046 |
8.52 nM [Ki] | ||
Target ID: CHEMBL2109244 Sources: http://www.genome.jp/dbget-bin/www_bget?D01593 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Erimin Approved UseThis medicine helps patients with difficulty sleeping due to stress and other reasons go to sleep by acting on the central nervous system. It is usually used to treat insomnia. |
PubMed
Title | Date | PubMed |
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Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles. | 2009 Dec 2 |
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Metabolic activation of benzodiazepines by CYP3A4. | 2009 Feb |
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Development and validation of an EI-GC-MS method for the determination of benzodiazepine drugs and their metabolites in blood: applications in clinical and forensic toxicology. | 2010 Aug 1 |
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Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
Patents
Sample Use Guides
In general, for adults, take 1 tablet (5 mg of the active ingredient) at a time, before bedtime (just before going to sleep).
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19005028
By exposure to 100 uM nimetazepam the cell viability in the presence of CYP3A4 decreased more than 25% compared with that of the control.
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DEA NO. |
2837
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NCI_THESAURUS |
C1012
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WIKIPEDIA |
Designer-drugs-Nimetazepam
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NIMETAZEPAM
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4532264KW6
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2011-67-8
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CHEMBL13341
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C002714
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DTXSID6023369
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C76536
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1936
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SUB09295MIG
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m7904
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100000083904
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ACTIVE MOIETY