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Details

Stereochemistry ACHIRAL
Molecular Formula C16H13N3O3
Molecular Weight 295.2927
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NIMETAZEPAM

SMILES

CN1C2=C(C=C(C=C2)[N+]([O-])=O)C(=NCC1=O)C3=CC=CC=C3

InChI

InChIKey=GWUSZQUVEVMBPI-UHFFFAOYSA-N
InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://www.cnb.gov.sg/drugs/bannedsubstance/nimetazepam.aspx

Nimetazepam (Erimin) is an intermediate-acting hypnotic drug which is a benzodiazepine derivative. It was first synthesized in 1962 in Japan. It does possess hypnotic, anxiolytic, sedative, and skeletal muscle relaxant properties. Nimetazepam is also an anticonvulsant. It is sold in 5 mg tablets known as Erimin. It is generally prescribed for the treatment of short-term severe insomnia in patients who have difficulty falling asleep or maintaining sleep. Nimetazepam is currently a Schedule IV drug under the international Convention on Psychotropic Substances of 1971. In Singapore, nimetazepam is a class C drug under the Misuse of Drugs Act. In Hong Kong, nimetazepam is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Nimetazepam can only be used legally by health professionals and for university research purposes.

Originator

Curator's Comment: First synthesized by a team at Hoffmann-La Roche in 1962 # Hoffmann-La Roche

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Erimin

Approved Use

This medicine helps patients with difficulty sleeping due to stress and other reasons go to sleep by acting on the central nervous system. It is usually used to treat insomnia.
PubMed

PubMed

TitleDatePubMed
Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.
2009 Dec 2
Metabolic activation of benzodiazepines by CYP3A4.
2009 Feb
Development and validation of an EI-GC-MS method for the determination of benzodiazepine drugs and their metabolites in blood: applications in clinical and forensic toxicology.
2010 Aug 1
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
2011 Jul 14
Patents

Sample Use Guides

In general, for adults, take 1 tablet (5 mg of the active ingredient) at a time, before bedtime (just before going to sleep).
Route of Administration: Oral
By exposure to 100 uM nimetazepam the cell viability in the presence of CYP3A4 decreased more than 25% compared with that of the control.
Name Type Language
NIMETAZEPAM
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
ERIMIN
Brand Name English
S-1530
Code English
NIMETAZEPAM [MART.]
Common Name English
NIMETAZEPAM [MI]
Common Name English
S 1530
Code English
nimetazepam [INN]
Common Name English
1,3-DIHYDRO-1-METHYL-7-NITRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE
Systematic Name English
Nimetazepam [WHO-DD]
Common Name English
NIMETAZEPAM [JAN]
Common Name English
Classification Tree Code System Code
DEA NO. 2837
Created by admin on Fri Dec 15 16:28:39 GMT 2023 , Edited by admin on Fri Dec 15 16:28:39 GMT 2023
NCI_THESAURUS C1012
Created by admin on Fri Dec 15 16:28:39 GMT 2023 , Edited by admin on Fri Dec 15 16:28:39 GMT 2023
WIKIPEDIA Designer-drugs-Nimetazepam
Created by admin on Fri Dec 15 16:28:39 GMT 2023 , Edited by admin on Fri Dec 15 16:28:39 GMT 2023
Code System Code Type Description
WIKIPEDIA
NIMETAZEPAM
Created by admin on Fri Dec 15 16:28:39 GMT 2023 , Edited by admin on Fri Dec 15 16:28:39 GMT 2023
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FDA UNII
4532264KW6
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INN
3150
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CHEBI
31912
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CAS
2011-67-8
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PUBCHEM
4496
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ECHA (EC/EINECS)
217-931-5
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ChEMBL
CHEMBL13341
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MESH
C002714
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EPA CompTox
DTXSID6023369
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NCI_THESAURUS
C76536
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DRUG CENTRAL
1936
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EVMPD
SUB09295MIG
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MERCK INDEX
m7904
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PRIMARY Merck Index
SMS_ID
100000083904
Created by admin on Fri Dec 15 16:28:39 GMT 2023 , Edited by admin on Fri Dec 15 16:28:39 GMT 2023
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