Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C26H43NO5 |
| Molecular Weight | 449.6233 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 10 / 10 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(=O)NCC(O)=O
InChI
InChIKey=GHCZAUBVMUEKKP-GYPHWSFCSA-N
InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Binding of bile acids by glutathione S-transferases from rat liver. | 1986 Sep |
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| Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. | 1998 Jan |
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| Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes. | 2001 Mar |
|
| [Effects of bile acid preparations on DNA biosynthesis, apoptosis, and necrosis in hepatocytes in vitro]. | 2001 Mar-Apr |
|
| The bcl-2 mRNA expression in GCDC-induced obstructive jaundice in rats and its implication in hepatocellular apoptosis. | 2002 |
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| [Release of cytochrome C with the interaction of bilirubin, amyloid beta-peptide and glycochenodeoxycholate from isolated mitochondria]. | 2002 Jul-Aug |
|
| Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes. | 2002 Nov |
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| Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. | 2003 Aug |
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| Gallium-67 activated charcoal: a new method for preparation of radioactive capsules for colonic transit study. | 2003 Jun |
|
| Bile salts inhibit growth and induce apoptosis of culture human normal esophageal mucosal epithelial cells. | 2005 Nov 7 |
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| Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum. | 2006 Aug |
|
| Determinants of cooperativity and site selectivity in human ileal bile acid binding protein. | 2006 Jan 24 |
|
| Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers. | 2006 May |
|
| Bile acids inhibit interleukin-6 signaling via gp130 receptor-dependent and -independent pathways in rat liver. | 2006 Nov |
|
| [Bile salts induce differentiation in cultured human normal esophageal mucosal epithelial cells]. | 2006 Sep 12 |
|
| Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation. | 2007 |
|
| Structural basis for bile salt inhibition of pancreatic phospholipase A2. | 2007 Jun 1 |
|
| Glycochenodeoxycholate (GCDC) inhibits cytokine induced iNOS expression in rat hepatocytes. | 2007 Mar |
|
| Taurodeoxycholate modulates apical Cl-/OH- exchange activity in Caco2 cells. | 2007 May |
|
| Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand. | 2008 Jul |
|
| Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury. | 2008 Sep |
|
| Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis. | 2012 |
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LOINC |
2066-9
Created by
admin on Sat Dec 16 01:03:04 GMT 2023 , Edited by admin on Sat Dec 16 01:03:04 GMT 2023
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| Code System | Code | Type | Description | ||
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Glycochenodeoxycholic acid
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DTXSID301020165
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36274
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12544
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DB02123
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640-79-9
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451ZNJ667Y
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admin on Sat Dec 16 01:03:04 GMT 2023 , Edited by admin on Sat Dec 16 01:03:04 GMT 2023
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SUBSTANCE RECORD
