Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H8 |
| Molecular Weight | 104.1491 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C=CC1=CC=CC=C1
InChI
InChIKey=PPBRXRYQALVLMV-UHFFFAOYSA-N
InChI=1S/C8H8/c1-2-8-6-4-3-5-7-8/h2-7H,1H2
DescriptionCurator's Comment: Description was created using several sources including:
http://www.ncbi.nlm.nih.gov/pubmed/16577143);
https://www3.epa.gov/ttn/atw/hlthef/styrene.html;
http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=18725
Curator's Comment: Description was created using several sources including:
http://www.ncbi.nlm.nih.gov/pubmed/16577143);
https://www3.epa.gov/ttn/atw/hlthef/styrene.html;
http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=18725
Styrene is used in the production of polystyrene plastics and resins, and in the synthesis of materials for ion exchange resins, and copolymer production. Styrene was originally extracted from the tree storax in 19th century. Its use in rubber production started at the beginning of the 20th century after in E.P. Heinmenn et al succeed in accelerating the polymerization of styrene to rubber in 1910. It is an oily colorless to yellow liquid found in many consumer products (plastic packaging, food containers, and household goods). Short-term exposure to styrene results in respiratory effects, eye irritation, and gastrointestinal effects. Long-term exposure has effects on the central nervous system. Exposure to styrene occurs due to emissions from building materials, consumer products, tobacco smoke, vehicle exhaust or occupational exposure during its industrial processing. Styrene is reasonably anticipated to be a human carcinogen.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Acrylonitrile removal from synthetic wastewater and actual industrial wastewater with high strength nitrogen using a pure bacteria culture. | 2001 |
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| The correlation between polarization modulated near-field optical images and the anisotropy of the probe. | 2001 Apr |
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| Base-catalyzed amination of olefins: an example of an environmentally friendly synthesis of amines. | 2001 Apr |
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| Monitoring biodegradation of VOCs using high-speed gas chromatography with a dual-point sampling system. | 2001 Apr 1 |
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| Thermolysis of free-radical initiators: tert-butylazocumene and its 1,3- and 1,4-bisazo and 1,3,5-trisazo analogues. | 2001 Apr 25 |
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| Simultaneous high-performance liquid chromatographic determination of urinary mandelic and phenylglyoxylic acids as indirect evaluation of styrene exposure. | 2001 Apr 5 |
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| Phenylene ethynylene diazonium salts as potential self-assembling molecular devices. | 2001 Apr 5 |
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| Blends of isoprene-styrene/methacrylate monomer systems as denture soft lining material. | 2001 Aug |
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| Metabolism of the styrene metabolite 4-vinylphenol by rat and mouse liver and lung. | 2001 Aug 10 |
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| The nonmutagenic (R)- and (S)-beta-(N(6)-adenyl)styrene oxide adducts are oriented in the major groove and show little perturbation to DNA structure. | 2001 Aug 21 |
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| Self-assembly of folded m-phenylene ethynylene oligomers into helical columns. | 2001 Aug 22 |
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| Metabolism of styrene in the human liver in vitro: interindividual variation and enantioselectivity. | 2001 Feb |
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| The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. | 2001 Feb |
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| Asymmetric hydrosilylation of styrenes catalyzed by palladium-MOP complexes: ligand modification and mechanistic studies. | 2001 Feb 23 |
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| A new polymer-anchored chiral catalyst for asymmetric Michael addition reactions. | 2001 Feb 8 |
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| Cloning and biochemical characterization of Co(2+)-activated bromoperoxidase-esterase (perhydrolase) from Pseudomonas putida IF-3 strain. | 2001 Feb 9 |
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| Highly enantioselective and regioselective biocatalytic azidolysis of aromatic epoxides. | 2001 Jan 11 |
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| Predominant 1,2-insertion of styrene in the Pd-catalyzed alternating copolymerization with carbon monoxide. | 2001 Jan 31 |
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| Chemiluminescent flow-through sensor for 1,10-phenanthroline based on the combination of molecular imprinting and chemiluminescence. | 2001 Jun |
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| Toxicity tests to assess pollutants removal during wastewater treatment and the quality of receiving waters in Argentina. | 2001 Jun |
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| Leukemia and exposure to 1,3-butadiene, styrene and dimethyldithiocarbamate among workers in the synthetic rubber industry. | 2001 Jun 1 |
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| Characterization of volatile organic compounds in smoke at experimental fires. | 2001 Jun 8 |
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| The toxicity of styrene monomer. | 2001 Mar |
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| Enhanced biodegradation of petrochemical wastewater using ozonation and BAC advanced treatment system. | 2001 Mar |
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| Soluble electroluminescent poly(phenylene vinylene)s with balanced electron- and hole injections. | 2001 Mar 14 |
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| Oligonucleotide-directed assembly of materials: defined oligomers. | 2001 Mar 7 |
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| [Use of gas and liquid chromatography methods in studying the metabolism of organic compounds (review)]. | 2001 Mar-Apr |
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| Metabolic capacity and interindividual variation in toxicokinetics of styrene in volunteers. | 2001 May |
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| Direct synthesis of previously inaccessible bridgehead azabicyclics by intramolecular cyclization of alpha-sulfonamido and alpha-sulfonimido radicals. | 2001 May 18 |
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| Hazards associated with the boat building industry in New Zealand. | 2001 May 25 |
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| Asymmetric inter- and intramolecular cyclopropanation of alkenes catalyzed by chiral ruthenium porphyrins. Synthesis and crystal structure of a chiral metalloporphyrin carbene complex. | 2001 May 9 |
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| Isoprene-styrene copolymer elastomer and tetrahydrofurfuryl methacrylate mixtures for soft prosthetic applications. | 2001 Sep |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: In an experimental human study, the kinetics of styrene metabolism in 8 male workers from the plastics industry were compared with those of 8 subjects not previously exposed to solvents. About 63% of the amount supplied (4.6 mmol styrene) was taken up in the body.
2.84 mmol/m3 (296 mg/m3) styrene exposure for 2 hours during light physical exercise.
Route of Administration:
Respiratory
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CFR |
21 CFR 172.515
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Food Contact Sustance Notif, (FCN No.) |
FCN NO. 1145
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METABOLITE (PARENT)
SUBSTANCE RECORD
