U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C4H4N2O3
Molecular Weight 128.0862
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISOBARBITURIC ACID

SMILES

O=C1NCC(=O)C(=O)N1

InChI

InChIKey=FQXOOGHQVPKHPG-UHFFFAOYSA-N
InChI=1S/C4H4N2O3/c7-2-1-5-4(9)6-3(2)8/h1H2,(H2,5,6,8,9)

HIDE SMILES / InChI

Approval Year

PubMed

PubMed

TitleDatePubMed
A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.
2002 Nov 1
5-hydroxyuracil can form stable base pairs with all four bases in a DNA duplex.
2005 Jan 21
Physical and functional interactions between Escherichia coli MutY and endonuclease VIII.
2006 Jan 1
RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors.
2006 Nov 29
DNA oxidation in Alzheimer's disease.
2006 Nov-Dec
Base excision repair and the role of MUTYH.
2007 Dec 15
Base excision repair activities in organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation.
2008 Jun 1
Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats.
2009 Jul
Insights into the role of Val45 and Gln182 of Escherichia coli MutY in DNA substrate binding and specificity.
2009 Jun 12
The Base Excision Repair system of Salmonella enterica serovar typhimurium counteracts DNA damage by host nitric oxide.
2009 May
Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair.
2010 Dec 16
Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases.
2010 Jun 4
Base-promoted reaction of 5-hydroxyuracil derivatives with peroxyl radicals.
2010 Sep 17
Name Type Language
ISOBARBITURIC ACID
Common Name English
5-HYDROXY-2,4(1H,3H)-PYRIMIDINEDIONE
Systematic Name English
FLUOROURACIL RELATED COMPOUND B [USP IMPURITY]
USP-RS  
Common Name English
DIHYDROPYRIMIDINE-2,4,5(3H)-TRIONE
Systematic Name English
NSC-90431
Code English
2,4(1H,3H)-PYRIMIDINEDIONE, 5-HYDROXY-
Systematic Name English
2,4,5(3H)-PYRIMIDINETRIONE, DIHYDRO-
Systematic Name English
5-HYDROXYURACIL
Systematic Name English
FLUOROURACIL RELATED COMPOUND B [USP-RS]
Common Name English
FLUOROURACIL IMPURITY B [EP IMPURITY]
Common Name English
NSC-95958
Code English
Code System Code Type Description
EPA CompTox
DTXSID30174667
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
PRIMARY
NSC
90431
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
PRIMARY
CHEBI
29115
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
PRIMARY
RS_ITEM_NUM
1279021
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
PRIMARY
WIKIPEDIA
5-Hydroxyuracil
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
PRIMARY
ECHA (EC/EINECS)
207-829-9
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
PRIMARY
CAS
496-76-4
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
PRIMARY
NSC
95958
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
PRIMARY
PUBCHEM
96994
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
PRIMARY
FDA UNII
438WJI1S49
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
PRIMARY
CAS
95035-33-9
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
ALTERNATIVE
ECHA (EC/EINECS)
243-932-5
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
ALTERNATIVE
CAS
20636-41-3
Created by admin on Sat Dec 16 00:42:07 GMT 2023 , Edited by admin on Sat Dec 16 00:42:07 GMT 2023
ALTERNATIVE