ISOBARBITURIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H4N2O3
Molecular Weight	128.0862
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1NCC(=O)C(=O)N1

InChI

InChIKey=FQXOOGHQVPKHPG-UHFFFAOYSA-N

InChI=1S/C4H4N2O3/c7-2-1-5-4(9)6-3(2)8/h1H2,(H2,5,6,8,9)

HIDE SMILES / InChI

Molecular Formula	C4H4N2O3
Molecular Weight	128.0862
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii.	1994 Aug 17	8080452
New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase.	1994 Jul 22	8034633
Oxidative DNA base modifications and polycyclic aromatic hydrocarbon DNA adducts in squamous cell carcinoma of larynx.	2003 Mar	12688418
Reaction of substituted pyrimidines with photochemically generated t-BuO* radicals.	2005 Dec	16955740
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells.	2006 Dec 9	16982218
Differential modulation of base excision repair activities during brain ontogeny: implications for repair of transcribed DNA.	2006 Jan	16257035
Physical and functional interactions between Escherichia coli MutY and endonuclease VIII.	2006 Jan 1	16201966
Ab initio base-pairing energies of uracil and 5-hydroxyuracil with standard DNA bases at the BSSE-free DFT and MP2 theory levels.	2006 May 7	16633566
Examination of hypochlorous acid-induced damage to cytosine residues in a CpG dinucleotide in DNA.	2008 Jun	18826175
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1.	2008 Oct 3	18662981
Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors.	2009 Mar 5	19265512
Sources of extracellular, oxidatively-modified DNA lesions: implications for their measurement in urine.	2009 Nov	19902015
Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair.	2010 Dec 16	21209706
RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures.	2010 Jun 4	20338831

Substance Class	Chemical Created by `admin` on `Sat Dec 16 00:42:07 GMT 2023` Edited by `admin` on `Sat Dec 16 00:42:07 GMT 2023`
Record UNII	438WJI1S49
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISOBARBITURIC ACID

Common Name

English

5-HYDROXY-2,4(1H,3H)-PYRIMIDINEDIONE

Systematic Name

English

FLUOROURACIL RELATED COMPOUND B [USP IMPURITY]

Common Name

English

DIHYDROPYRIMIDINE-2,4,5(3H)-TRIONE

Systematic Name

English

NSC-90431

Code

English

2,4(1H,3H)-PYRIMIDINEDIONE, 5-HYDROXY-

Systematic Name

English

2,4,5(3H)-PYRIMIDINETRIONE, DIHYDRO-

Systematic Name

English

5-HYDROXYURACIL

Systematic Name

English

FLUOROURACIL RELATED COMPOUND B [USP-RS]

Common Name

English

FLUOROURACIL IMPURITY B [EP IMPURITY]

Common Name

English

NSC-95958

Code

English

Code System Code Type Description

EPA CompTox

DTXSID30174667