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Details

Stereochemistry ABSOLUTE
Molecular Formula C32H38N2O8
Molecular Weight 578.6527
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEFESERPINE

SMILES

[H][C@]12C[C@@H](OC(=O)COC3=CC=C(OC)C=C3)[C@H](OC)[C@@H](C(=O)OC)[C@@]1([H])C[C@@]4([H])N(CCC5=C4NC6=CC(OC)=CC=C56)C2

InChI

InChIKey=KFDDPVMIQMFHBI-JLIPXIIDSA-N
InChI=1S/C32H38N2O8/c1-37-19-5-7-20(8-6-19)41-17-28(35)42-27-13-18-16-34-12-11-23-22-10-9-21(38-2)14-25(22)33-30(23)26(34)15-24(18)29(31(27)39-3)32(36)40-4/h5-10,14,18,24,26-27,29,31,33H,11-13,15-17H2,1-4H3/t18-,24+,26-,27-,29+,31+/m1/s1

HIDE SMILES / InChI

Description

Mefeserpine (Methoxyphenoserpine) is a hypotensive reserpoid with a weak central depressive effect.

CNS Activity

CNS Active
3,913

Originator

Trcka, V. et al.
1

Approval Year

Unknown
139,594

Conditions

ConditionModalityTargetsHighest PhaseProduct
Hypertension
567
 Primary
Approved
8,429
Unknown

PubMed

Patents

US20060110428
2
US20140154313
3
US6331289
5
US6680047B2
5
WO2012170676A1
2

Sample Use Guides

In Vivo Use Guide
Rats: The dose of 25.0 mg/kg causing the comparable increase of the concentration of pepsin in the gastric juice of normal rats is 5 times higher than that of reserpine.
Route of Administration: Intraperitoneal
In Vitro Use Guide
Unknown
ACTIVE MOIETY
Structure of MEFESERPINE
NIH
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