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Details

Stereochemistry ACHIRAL
Molecular Formula C21H24FN3O2
Molecular Weight 369.4326
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of JNJ-39220675

SMILES

FC1=CC=C(OC2=NC=C(C=C2)C(=O)N3CCCN(CC3)C4CCC4)C=C1

InChI

InChIKey=IQOWHZHNGJXGHG-UHFFFAOYSA-N
InChI=1S/C21H24FN3O2/c22-17-6-8-19(9-7-17)27-20-10-5-16(15-23-20)21(26)25-12-2-11-24(13-14-25)18-3-1-4-18/h5-10,15,18H,1-4,11-14H2

HIDE SMILES / InChI
JNJ-39220675, an aryloxypyridine amide, is a selective histamine H3 receptor antagonist. JNJ-39220675 was under development for the treatment of allergic rhinitis.

CNS Activity

Curator's Comment: Known to be CNS active in rat. Human data not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon.
2012-10
JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.
2011-04
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
2010-07-15
Name Type Language
JNJ 39220675
Preferred Name English
JNJ-39220675
Common Name English
METHANONE, (4-CYCLOBUTYLHEXAHYDRO-1H-1,4-DIAZEPIN-1-YL)(6-(4-FLUOROPHENOXY)-3-PYRIDINYL)-
Systematic Name English
Code System Code Type Description
DRUG BANK
DB12929
Created by admin on Mon Mar 31 18:03:07 GMT 2025 , Edited by admin on Mon Mar 31 18:03:07 GMT 2025
PRIMARY
PUBCHEM
24771368
Created by admin on Mon Mar 31 18:03:07 GMT 2025 , Edited by admin on Mon Mar 31 18:03:07 GMT 2025
PRIMARY
CAS
959740-39-7
Created by admin on Mon Mar 31 18:03:07 GMT 2025 , Edited by admin on Mon Mar 31 18:03:07 GMT 2025
PRIMARY
FDA UNII
41WC0AZ27V
Created by admin on Mon Mar 31 18:03:07 GMT 2025 , Edited by admin on Mon Mar 31 18:03:07 GMT 2025
PRIMARY
EPA CompTox
DTXSID90242053
Created by admin on Mon Mar 31 18:03:07 GMT 2025 , Edited by admin on Mon Mar 31 18:03:07 GMT 2025
PRIMARY