Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H24FN3O2 |
| Molecular Weight | 369.4326 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC1=CC=C(OC2=NC=C(C=C2)C(=O)N3CCCN(CC3)C4CCC4)C=C1
InChI
InChIKey=IQOWHZHNGJXGHG-UHFFFAOYSA-N
InChI=1S/C21H24FN3O2/c22-17-6-8-19(9-7-17)27-20-10-5-16(15-23-20)21(26)25-12-2-11-24(13-14-25)18-3-1-4-18/h5-10,15,18H,1-4,11-14H2
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20561786
Curator's Comment: Known to be CNS active in rat. Human data not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon. | 2012-10 |
|
| JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. | 2011-04 |
|
| Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development. | 2010-07-15 |
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DB12929
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24771368
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959740-39-7
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41WC0AZ27V
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DTXSID90242053
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SUBSTANCE RECORD