JNJ-39220675

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H24FN3O2
Molecular Weight	369.4326
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(OC2=CC=C(C=N2)C(=O)N3CCCN(CC3)C4CCC4)C=C1

InChI

InChIKey=IQOWHZHNGJXGHG-UHFFFAOYSA-N

InChI=1S/C21H24FN3O2/c22-17-6-8-19(9-7-17)27-20-10-5-16(15-23-20)21(26)25-12-2-11-24(13-14-25)18-3-1-4-18/h5-10,15,18H,1-4,11-14H2

HIDE SMILES / InChI

Molecular Formula	C21H24FN3O2
Molecular Weight	369.4326
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20561786 | https://clinicaltrials.gov/ct2/show/study/NCT00804687

JNJ-39220675, an aryloxypyridine amide, is a selective histamine H3 receptor antagonist. JNJ-39220675 was under development for the treatment of allergic rhinitis.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.	2010 Jul 15	20561786

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:37:02 GMT 2023` Edited by `admin` on `Fri Dec 15 15:37:02 GMT 2023`
Record UNII	41WC0AZ27V
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

JNJ-39220675

Common Name

English

JNJ 39220675

Common Name

English

METHANONE, (4-CYCLOBUTYLHEXAHYDRO-1H-1,4-DIAZEPIN-1-YL)(6-(4-FLUOROPHENOXY)-3-PYRIDINYL)-

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB12929