Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H23NO3.ClH.2H2O |
| Molecular Weight | 385.882 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.Cl.[H][C@@]12OC3=C4C(C[C@@]5([H])N(C)CC[C@@]14[C@@]5([H])C=C[C@@H]2O)=CC=C3OCC
InChI
InChIKey=FKEDUFRSQFFLHR-VSYPDCRNSA-N
InChI=1S/C19H23NO3.ClH.2H2O/c1-3-22-15-7-4-11-10-13-12-5-6-14(21)18-19(12,8-9-20(13)2)16(11)17(15)23-18;;;/h4-7,12-14,18,21H,3,8-10H2,1-2H3;1H;2*1H2/t12-,13+,14-,18-,19-;;;/m0.../s1
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
1.09 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7654478 |
1.5 mg/kg bw single, oral dose: 1.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
ETHYLMORPHINE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
222 μM × min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7654478 |
1.5 mg/kg bw single, oral dose: 1.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
ETHYLMORPHINE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
1.97 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7654478 |
1.5 mg/kg bw single, oral dose: 1.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
ETHYLMORPHINE serum | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
Doses
| Dose | Population | Adverse events |
|---|---|---|
8.5 mg single, oral |
healthy, 10 months n = 1 Health Status: healthy Age Group: 10 months Sex: M Population Size: 1 Sources: |
Other AEs: Sedation... |
1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: |
healthy, 24 years n = 10 Health Status: healthy Age Group: 24 years Sex: M Population Size: 10 Sources: |
Other AEs: Dizziness, Drowsiness... Other AEs: Dizziness (7 patients) Sources: Drowsiness (slight, 2 patients) Loose stools (1 patient) |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Sedation | grade 5 | 8.5 mg single, oral |
healthy, 10 months n = 1 Health Status: healthy Age Group: 10 months Sex: M Population Size: 1 Sources: |
| Loose stools | 1 patient | 1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: |
healthy, 24 years n = 10 Health Status: healthy Age Group: 24 years Sex: M Population Size: 10 Sources: |
| Dizziness | 7 patients | 1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: |
healthy, 24 years n = 10 Health Status: healthy Age Group: 24 years Sex: M Population Size: 10 Sources: |
| Drowsiness | slight, 2 patients | 1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: |
healthy, 24 years n = 10 Health Status: healthy Age Group: 24 years Sex: M Population Size: 10 Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model. | 1997 Apr |
|
| Interpretation of the presence of 6-monoacetylmorphine in the absence of morphine-3-glucuronide in urine samples: evidence of heroin abuse. | 2003 Oct |
|
| Evaluation of the One-Step ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens. | 2004 Jul 16 |
|
| Validation of direct injection electrospray LC-MS/MS for confirmation of opiates in urine drug testing. | 2007 Jul |
|
| A hybrid FIA/HPLC system incorporating monolithic column chromatography. | 2007 Sep 26 |
|
| Determining plasma morphine levels using GC-MS after solid phase extraction to monitor drug levels in the postoperative period. | 2008 Jun |
|
| Importance of using highly pure internal standards for successful liquid chromatography/tandem mass spectrometric bioanalytical assays. | 2009 May |
|
| Characterization of xenobiotic metabolizing enzymes in bovine small intestinal mucosa. | 2010 Jun 1 |
|
| Death of a 10-month-old boy after exposure to ethylmorphine. | 2010 Mar 1 |
Sample Use Guides
The recommended dose in adults is 50 mg of codethyline per day, i.e. 10 tablets (1 tablet contains 5 mg of ethylmorphine hydrochloride) per day over several intakes, at a minimum of 4 hours apart. In children the normal dose is 1 tablet per intake, to be renewed after 6 hours if necessary, without exceeding 4 tablets per day.
Route of Administration:
Oral
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NCI_THESAURUS |
C67413
Created by
admin on Fri Dec 15 17:26:53 GMT 2023 , Edited by admin on Fri Dec 15 17:26:53 GMT 2023
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m5154
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PRIMARY | Merck Index | ||
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C87358
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DTXSID90986728
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300000037439
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407X3NQV4N
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5360215
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6746-59-4
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
