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Details

Stereochemistry ACHIRAL
Molecular Formula C17H16ClN5O2
Molecular Weight 357.794
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PF-04531083

SMILES

COC1=CC=C(Cl)C(=C1)C2=C(N)N=C(NC(=O)C3=CC=NN3C)C=C2

InChI

InChIKey=ZRJGMDIPCQOGNI-UHFFFAOYSA-N
InChI=1S/C17H16ClN5O2/c1-23-14(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(25-2)3-5-13(12)18/h3-9H,1-2H3,(H3,19,21,22,24)

HIDE SMILES / InChI
PF-04531083 is selective Nav1.8 blocker. It has been investigated for the treatment of chronic pain, heart pain, post-surgical dental pain. However, these trials were discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Recent progress in sodium channel modulators for pain.
2014 Aug 15

Sample Use Guides

Single dose - 1000 mg or 2000 mg
Route of Administration: Oral
Name Type Language
PF-04531083
Common Name English
PF-4531083
Code English
1H-PYRAZOLE-5-CARBOXAMIDE, N-(6-AMINO-5-(2-CHLORO-5-METHOXYPHENYL)-2-PYRIDINYL)-1-METHYL-
Systematic Name English
Code System Code Type Description
DRUG BANK
DB12468
Created by admin on Sat Dec 16 01:46:59 GMT 2023 , Edited by admin on Sat Dec 16 01:46:59 GMT 2023
PRIMARY
CAS
1079400-07-9
Created by admin on Sat Dec 16 01:46:59 GMT 2023 , Edited by admin on Sat Dec 16 01:46:59 GMT 2023
PRIMARY
CLINICAL_TRIALS.GOV
PF-04531083
Created by admin on Sat Dec 16 01:46:59 GMT 2023 , Edited by admin on Sat Dec 16 01:46:59 GMT 2023
PRIMARY 6 studies found for: PF-04531083
MANUFACTURER PRODUCT INFORMATION
PF-04531083
Created by admin on Sat Dec 16 01:46:59 GMT 2023 , Edited by admin on Sat Dec 16 01:46:59 GMT 2023
PRIMARY PF-04531083: Synonym: N-(6-Amino-5-(2-chloro-5-methoxyphenyl)-2-pyridinyl)-1-methyl-1H-pyrazole-5-carboxamide, N-(6-Amino-5-(2-chloro-5-methoxyphenyl)pyridin-2-yl)-1-methyl-1H-pyrazole-5-carboxamide, PF 4531083
SMS_ID
300000041337
Created by admin on Sat Dec 16 01:46:59 GMT 2023 , Edited by admin on Sat Dec 16 01:46:59 GMT 2023
PRIMARY
PUBCHEM
57582353
Created by admin on Sat Dec 16 01:46:59 GMT 2023 , Edited by admin on Sat Dec 16 01:46:59 GMT 2023
PRIMARY
FDA UNII
40497CY7Y3
Created by admin on Sat Dec 16 01:46:59 GMT 2023 , Edited by admin on Sat Dec 16 01:46:59 GMT 2023
PRIMARY
ChEMBL
CHEMBL3544951
Created by admin on Sat Dec 16 01:46:59 GMT 2023 , Edited by admin on Sat Dec 16 01:46:59 GMT 2023
PRIMARY