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Details

Stereochemistry RACEMIC
Molecular Formula 2C19H24N2O2.2C7H8O3S.H2O
Molecular Weight 987.231
Optical Activity ( + / - )
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of XYLAMIDINE TOSYLATE HEMIHYDRATE

SMILES

O.CC1=CC=C(C=C1)S(O)(=O)=O.CC2=CC=C(C=C2)S(O)(=O)=O.COC3=CC=CC(OC(C)CNC(=N)CC4=CC=CC(C)=C4)=C3.COC5=CC=CC(OC(C)CNC(=N)CC6=CC=CC(C)=C6)=C5

InChI

InChIKey=FKFRSAWYMDRWMY-UHFFFAOYSA-N
InChI=1S/2C19H24N2O2.2C7H8O3S.H2O/c2*1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3;2*1-6-2-4-7(5-3-6)11(8,9)10;/h2*4-10,12,15H,11,13H2,1-3H3,(H2,20,21);2*2-5H,1H3,(H,8,9,10);1H2

HIDE SMILES / InChI

Description

Xylamidine is a peripherally-restricted antagonist of 5HT2A and 5HT1A receptor. It is used to study the role of the serotonin receptors in the regulation of food intake, cardiovascular function, and regulation of body temperature.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
5-HT activates vagal afferent cell bodies in vivo: role of 5-HT2 and 5-HT3 receptors.
2006-11-17
Differential effects of nitroblue tetrazolium on the hemodynamic responses elicited by activation of alpha1-adrenoceptors and 5-HT2 receptors in conscious rats.
2006-03-27
Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.
2004-12-03
Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit.
2004-03
Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.
2003-03
Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms.
1991-12
Effects of xylamidine on peripheral 5-hydroxytryptamine-induced anorexia.
1989-12
Name Type Language
N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE MONO-P-TOLUENESULFONATE HEMIHYDRATE
Preferred Name English
XYLAMIDINE TOSYLATE HEMIHYDRATE
Common Name English
N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE MONO-P-TOLUENESULPHONATE HEMIHYDRATE
Common Name English
XYLAMIDINE TOSILATE HEMIHYDRATE
Common Name English
BENZENEETHANIMIDAMIDE, N-(2-(3-METHOXYPHENOXY)PROPYL)-3-METHYL-, 4-METHYLBENZENESULFONATE, HYDRATE (2:2:1)
Systematic Name English
Code System Code Type Description
FDA UNII
3Z1VNM4T7B
Created by admin on Mon Mar 31 18:30:34 GMT 2025 , Edited by admin on Mon Mar 31 18:30:34 GMT 2025
PRIMARY
CAS
13717-05-0
Created by admin on Mon Mar 31 18:30:34 GMT 2025 , Edited by admin on Mon Mar 31 18:30:34 GMT 2025
PRIMARY
PUBCHEM
23725073
Created by admin on Mon Mar 31 18:30:34 GMT 2025 , Edited by admin on Mon Mar 31 18:30:34 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of XYLAMIDINE
NIH
NCATS
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