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Details

Stereochemistry RACEMIC
Molecular Formula 2C19H24N2O2.2C7H8O3S.H2O
Molecular Weight 987.231
Optical Activity ( + / - )
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of XYLAMIDINE TOSYLATE HEMIHYDRATE

SMILES

O.CC1=CC=C(C=C1)S(O)(=O)=O.CC2=CC=C(C=C2)S(O)(=O)=O.COC3=CC=CC(OC(C)CNC(=N)CC4=CC=CC(C)=C4)=C3.COC5=CC=CC(OC(C)CNC(=N)CC6=CC=CC(C)=C6)=C5

InChI

InChIKey=FKFRSAWYMDRWMY-UHFFFAOYSA-N
InChI=1S/2C19H24N2O2.2C7H8O3S.H2O/c2*1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3;2*1-6-2-4-7(5-3-6)11(8,9)10;/h2*4-10,12,15H,11,13H2,1-3H3,(H2,20,21);2*2-5H,1H3,(H,8,9,10);1H2

HIDE SMILES / InChI

Description

Xylamidine is a peripherally-restricted antagonist of 5HT2A and 5HT1A receptor. It is used to study the role of the serotonin receptors in the regulation of food intake, cardiovascular function, and regulation of body temperature.

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Effects of xylamidine on peripheral 5-hydroxytryptamine-induced anorexia.
1989 Dec
Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms.
1991 Dec
Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.
2003 Mar
Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.
2004 Dec 3
Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit.
2004 Mar
Differential effects of nitroblue tetrazolium on the hemodynamic responses elicited by activation of alpha1-adrenoceptors and 5-HT2 receptors in conscious rats.
2006 Mar 27
5-HT activates vagal afferent cell bodies in vivo: role of 5-HT2 and 5-HT3 receptors.
2006 Nov 17
Name Type Language
XYLAMIDINE TOSYLATE HEMIHYDRATE
Common Name English
N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE MONO-P-TOLUENESULFONATE HEMIHYDRATE
Common Name English
N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE MONO-P-TOLUENESULPHONATE HEMIHYDRATE
Common Name English
XYLAMIDINE TOSILATE HEMIHYDRATE
Common Name English
BENZENEETHANIMIDAMIDE, N-(2-(3-METHOXYPHENOXY)PROPYL)-3-METHYL-, 4-METHYLBENZENESULFONATE, HYDRATE (2:2:1)
Systematic Name English
Code System Code Type Description
FDA UNII
3Z1VNM4T7B
Created by admin on Fri Dec 15 16:31:47 GMT 2023 , Edited by admin on Fri Dec 15 16:31:47 GMT 2023
PRIMARY
CAS
13717-05-0
Created by admin on Fri Dec 15 16:31:47 GMT 2023 , Edited by admin on Fri Dec 15 16:31:47 GMT 2023
PRIMARY
PUBCHEM
23725073
Created by admin on Fri Dec 15 16:31:47 GMT 2023 , Edited by admin on Fri Dec 15 16:31:47 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of XYLAMIDINE
NIH
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