Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C11H9I3N2O4.C7H17NO5 |
Molecular Weight | 809.1272 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NC1=C(I)C(C(O)=O)=C(I)C(NC(C)=O)=C1I
InChI
InChIKey=MIKKOBKEXMRYFQ-WZTVWXICSA-N
InChI=1S/C11H9I3N2O4.C7H17NO5/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-2H3,(H,15,17)(H,16,18)(H,19,20);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
DescriptionSources: http://www.drugbank.ca/drugs/DB00271Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/010040s171lbl.pdf
Sources: http://www.drugbank.ca/drugs/DB00271
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/010040s171lbl.pdf
This compound belongs to the class of organic compounds known as aminobenzoic acids. These are benzoic acids containing an amine group attached to the benzene moiety. A commonly used x-ray contrast medium. Used, alone or in combination, for a wide variety of diagnostic imaging methods, including angiography, urography, cholangiography, computed tomography, hysterosalpingography, and retrograde pyelography. It can be used for imaging the gastrointestinal tract in patients allergic to barium. Radiopaque agents are drugs used to help diagnose certain medical problems. They contain iodine, which blocks x-rays. Depending on how the radiopaque agent is given, it localizes or builds up in certain areas of the body. The resulting high level of iodine allows the x-rays to make a "picture" of the area. The areas of the body in which the radiopaque agent localizes will appear white on the x-ray film. This creates the needed distinction, or contrast, between one organ and other tissues.
CNS Activity
Originator
Sources: http://www.ncbi.nlm.nih.gov/pubmed/?term=3198373
Curator's Comment: Diatrizoic acid was discovered in 1953 simultaneously and independently by Schering AG in Berlin and by Sterling-Winthrop in the USA.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Diagnostic | Cystografin Approved UseRetrograde cystourethrography Launch Date1955 |
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Diagnostic | Gastrografin Approved UseGastrografin (DIATRIZOIC ACID) is indicated for radiographic examination of segments of the gastrointestinal tract (esophagus, stomach, proximal small intestine, and colon). Launch Date1958 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
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7 mg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6706519 |
7.2 mg/kg single, intravenous dose: 7.2 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
HYDROGEN IODIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
3.6 mg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6706519 |
3.36 mg/kg single, intravenous dose: 3.36 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
HYDROGEN IODIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
102 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6706519 |
7.2 mg/kg single, intravenous dose: 7.2 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
HYDROGEN IODIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
110 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6706519 |
3.36 mg/kg single, intravenous dose: 3.36 mg/kg route of administration: Intravenous experiment type: SINGLE co-administered: |
HYDROGEN IODIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
PubMed
Title | Date | PubMed |
---|---|---|
Temporary pancreatic duct occlusion by ethibloc: cause of microcirculatory shutdown, acute inflammation, and pancreas necrosis. | 2001 Apr |
|
Shielding effects of metallic encapsulations and radiographic contrast agents for catheter-based intravascular brachytherapy. | 2001 Apr-Jun |
|
The use of dilute Calogen as a fat density oral contrast medium in upper abdominal computed tomography, compared with the use of water and positive oral contrast media. | 2001 Aug |
|
An analysis of mechanisms underlying the antifibrinolytic properties of radiographic contrast agents. | 2001 Dec |
|
The selective adenosine A1 receptor antagonist KW-3902 prevents radiocontrast media-induced nephropathy in rats with chronic nitric oxide deficiency. | 2001 Feb 23 |
|
[Evaluation of aqueous compartments of the body by integral bioimpedance spectrometry in x-ray surgical interventions in children]. | 2001 Jan-Feb |
|
Glucose alters the susceptibility of mesangial cells to contrast media. | 2001 Jul |
|
Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: effect on drug efflux. | 2001 Jun |
|
Effects in vivo of iohexol and diatrizoate on human plasma acetyl- and butyryl-cholinesterase activity. | 2001 Mar |
|
Harmonic scalpel in laparoscopic colorectal surgery. | 2001 Mar |
|
BaSO4-loaded agarose: a construction material for multimodality imaging phantoms. | 2001 May |
|
Changes in intrarenal oxygenation as evaluated by BOLD MRI in a rat kidney model for radiocontrast nephropathy. | 2001 May |
|
Contrast medium precipitation in the stomach between contiguous plain and contrast CT scans. | 2001 May-Jun |
|
Videourodynamic and sphincter motor unit potential analyses in Parkinson's disease and multiple system atrophy. | 2001 Nov |
|
Effect of ionic and nonionic contrast media on fibrinolysis in patients undergoing angiocardiography. | 2001 Oct |
|
[Which imaging in case of sigmoid diverticulitis? The value of ultrasound (Conventional B-mode in combination with hydrocolonsonography and colour flow Doppler) in comparison to the well-established modalities like contrast enema and helical computertomography]. | 2002 Apr |
|
Effect of iomeprol on rat hippocampal slice synaptic transmission: comparison with other X-ray contrast agents. | 2002 Apr |
|
Electrocardiographic effects of diagnostic imaging agents. | 2002 Aug |
|
Radiocontrast-induced renal tubular cell apoptosis: hypertonic versus oxidative stress. | 2002 Aug |
|
Thumbprinting due to ischemic colitis in a patient on oral anticoagulation. | 2002 Aug-Sep |
|
Use of near-infrared reflection spectroscopy to study the effects of X-ray contrast media on renal tolerance in rats: effects of a prostacyclin analogue and of phosphodiesterase inhibitors. | 2002 Dec |
|
Rectal washout with cytotoxic solution can be extended to the whole colon. | 2002 Dec |
|
Primary anastomosis and diverting colostomy in diffuse diverticular peritonitis. | 2002 Feb |
|
Systemic platelet effects of contrast media: implications for cardiologic research and clinical practice. | 2002 Jan |
|
Plasma exogenous creatinine clearance test in dogs: comparison with other methods and proposed limited sampling strategy. | 2002 Jan-Feb |
|
Assessment of hypothalamic-pituitary-adrenal axis function after corticosteroid therapy in inflammatory bowel disease. | 2002 Jul |
|
Local tissue toxicity in response to extravascular extravasation of magnetic resonance contrast media. | 2002 Jul |
|
Gastrocolocutaneous Fistula as a complication of peg tube placement. | 2002 Mar |
|
Changes in the fibrinolytic system during angiography with ionic and with nonionic contrast media. | 2002 Mar |
|
Long-term survival of patients with stage IV hypopharyngeal cancer: impact of fundus rotation gastroplasty. | 2002 May |
|
Renal excretion of ingested gastrografin: clinical relevance in early postoperative treatment of patients who have undergone gastric surgery. | 2002 May |
|
Safety and efficacy of postoperative continuous positive airway pressure to prevent pulmonary complications after Roux-en-Y gastric bypass. | 2002 May-Jun |
|
The role of theophylline in contrast-induced nephropathy: a case-control study. | 2002 Nov |
|
The value of contrast radiology for postoperative adhesive small bowel obstruction. | 2002 Nov-Dec |
|
Renal chemoembolization with mitomycin c/Ethibloc: pharmacokinetics and efficacy in an animal model. | 2002 Sep |
|
Iothalamate measured by capillary electrophoresis is a suitable alternative to radiolabeled inulin in renal micropuncture. | 2002 Sep |
|
[Fast method of labelling leukocytes with 99mTc HM PAO]. | 2002 Sep-Oct |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: For radiographic examination of segments of the gastrointestinal tract (Gastrografin) oral administration: adult oral dosage may range from 30 to 90 mL (11 to 33 g iodine), depending on the nature of the examination and the size of the patient. For Enemas or Enterostomy Instillations: should be diluted when it is used for enemas and enterostomy instillations. When used as an enema, the suggested dilution for adults is 240 mL (88 g iodine) in 1,000 mL of tap water. http://www.drugs.com/pro/gastrografin.html
;
The dose for retrograde use in cystography and voiding cystourethrography ranges from 25 to 300 mL depending on the age of the patient and the degree of bladder irritability
Route of Administration:
Other
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C28500
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CFR |
21 CFR 522.563
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100000091437
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131-49-7
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31812
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CHEMBL1201220
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DTXSID20897171
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m4263
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205-024-7
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53692
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4208
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3X9MR4N98U
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SUB03119MIG
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3X9MR4N98U
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DBSALT000844
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8566
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C29247
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D003974
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3320
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PRIMARY | RxNorm |
ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD