URANYL NITRATE HEXAHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	2NO3.2O.U.6H2O
Molecular Weight	502.1292
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.O.O.O.O.[O--].[O--].[U+6].[O-][N+]([O-])=O.[O-][N+]([O-])=O

InChI

InChIKey=QPHPCSJNIDEUEH-UHFFFAOYSA-N

InChI=1S/2NO3.6H2O.2O.U/c2*2-1(3)4;;;;;;;;;/h;;6*1H2;;;/q2*-1;;;;;;;2*-2;+6

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Description
Sources: http://www2.mst.dk/Udgiv/publications/2013/12/978-87-93026-82-7.pdf

There is no information related biological or pharmacological application of sodium diuranate. This is slightly soluble salts, which possesses some toxicity, that has been studied on rabbits

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Pathological and biochemical modifications of renal function in ibuprofen-induced interstitial nephritis.	1996 Jan	8820499
Calcium-binding proteins annexin A2 and S100A6 are sensors of tubular injury and recovery in acute renal failure.	2005 Dec	16316344
Uranium induces apoptosis and is genotoxic to normal rat kidney (NRK-52E) proximal cells.	2007 Aug	17522072
Cholesterol 7alpha-hydroxylase (CYP7A1) activity is modified after chronic ingestion of depleted uranium in the rat.	2010 May	20362056
Increased urinary excretion of albumin, hemopexin, transferrin and VDBP correlates with chronic sensitization to gentamicin nephrotoxicity in rats.	2013 Feb 8	23261757
Molecular, cellular, and tissue impact of depleted uranium on xenobiotic-metabolizing enzymes.	2014 Feb	24146111
Low-concentration uranium enters the HepG2 cell nucleus rapidly and induces cell stress response.	2015 Dec 25	26362510
Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth.	2015 Feb	25743749
Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity.	2015 Sep 15	26148447
Ghrelin protects against depleted uranium-induced apoptosis of MC3T3-E1 cells through oxidative stress-mediated p38-mitogen-activated protein kinase pathway.	2016 Jan 1	26529667

Patents

Sample Use Guides

In Vivo Use Guide

toxic effect in rabbits: 4-hour exposures to uranium compounds using a lanolin vehicle showed that water-soluble compounds (uranyl fluoride, uranium tetrachloride, uranium pentachloride) were the most toxic; the slightly soluble compounds (uranium trioxide, sodium diuranate, ammonium diuranate) were less toxic, and the water insoluble compounds (uranium tetrafluoride, uranium dioxide, uranium peroxide, uriuranium octoxide) caused no deaths.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

URANYL NITRATE HEXAHYDRATE

Common Name

English

URANIUM, BIS(NITRATO)DIOXO-, HEXAHYDRATE

Common Name

English

URANYL NITRATE HEXAHYDRATE [MI]

Common Name

English

DINITRATODIOXOURANIUM HEXAHYDRATE

Common Name

English

URANIUM NITRICUM [HPUS]

Common Name

English

URANYL NITRATE, HEXAHYDRATE

Common Name

English

URANIUM NITRICUM

Common Name

English

URANYL DINITRATE HEXAHYDRATE

Common Name

English

Code System Code Type Description

FDA UNII

3V057702FY