RISOTILIDE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H27N3O4S2.ClH
Molecular Weight	413.984
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)NCCN(C(C)C)S(=O)(=O)C1=CC=C(NS(C)(=O)=O)C=C1

InChI

InChIKey=RFMZRLGPSDNVKE-UHFFFAOYSA-N

InChI=1S/C15H27N3O4S2.ClH/c1-12(2)16-10-11-18(13(3)4)24(21,22)15-8-6-14(7-9-15)17-23(5,19)20;/h6-9,12-13,16-17H,10-11H2,1-5H3;1H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1645624 | https://adisinsight.springer.com/drugs/800002381 | https://www.ncbi.nlm.nih.gov/pubmed/8961081 | https://books.google.com/books?id=uabziZlZEDYC&pg=PA90&lpg=PA90&dq=Risotilide&source=bl&ots=SxizZndFkv&sig=ACfU3U2vYJegTSP-otw_mwmJABqS8ld2ag&hl=en&sa=X&ved=2ahUKEwjX0IzbhJLjAhXNGDQIHfbRD6Q4ChDoATAAegQICBAB#v=onepage&q=Risotilide&f=false

Risotilide is a Class III antiarrhythmic agent that inhibits the voltage-dependent potassium channel. Risotilide prolongs cardiac action potentials and refractory periods. It was shown to reduce ventricular vulnerability in a study on arrhythmogenic effects of left ventricular hypertrophy (LVH) in the intact heart in cats. Phase I and II trials have been conducted, but development of this drug has been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
calcium-activated potassium channel activity 3 Target ID: GO:0015269 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2017153	Blocker 555

Patents

Name

Type

Language

RISOTILIDE HYDROCHLORIDE

Official Name

English

WY-48,986

Preferred Name

English

WY-48986

Code

English

4'-(ISOPROPYL(2-(ISOPROPYLAMINO)ETHYL)SULFAMOYL)METHANESULFONANILIDE MONOHYDROCHLORIDE

Systematic Name

English

BENZENESULFONAMIDE, N-(1-METHYLETHYL)-N-(2-((1-METHYLETHYL)AMINO)ETHYL)-4-((METHYLSULFONYL)AMINO)-, MONOHYDROCHLORIDE

Common Name

English

RISOTILIDE HYDROCHLORIDE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793