Lefelsiran

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Name

Type

Language

Lefelsiran

Official Name

English

DCR-1203 FREE ACID

Preferred Name

English

all-P-ambo-(3'?5')-2'-O-methyl-P-thioguanylyl-(3'?5')-2'-O-methyl-P-thioguanylyl-(3'?5')-2'-O-methyl-P-thiocytidylyl-(3'?5')-2'-O-methylcytidylyl-(3'?5')-2'-O-methyladenylyl-(3'?5')-2'-O-methylcytidylyl-(3'?5')-2'-O-methylcytidylyl-(3'?5')-2'-O-methyluri

Common Name

English

DCR-A1203 FREE ACID

Code

English

LEFELSIRAN [USAN]

Common Name

English

lefelsiran [INN]

Common Name

English

RNA, ([4?-de(hydroxymethyl)-4?-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2?-deoxy-2?-fluoro)A-sp-(2?-deoxy-2?-fluoro)A-sp-(2?-deoxy-2?-fluoro)A-(2?-deoxy-2?-fluoro)C-Um-(2?-deoxy-2?-fluoro)G-Am-Gm-Um-Um-Um-Cm-(2?-deoxy-2?-fluoro)A-Um-Cm-Cm-Am-Cm-Cm-sp-G

Common Name

English

Code System Code Type Description

INN

12851

Created by admin on Wed Apr 02 13:17:45 GMT 2025 , Edited by admin on Wed Apr 02 13:17:45 GMT 2025

PRIMARY

SMS_ID

300000027471

Created by admin on Wed Apr 02 13:17:45 GMT 2025 , Edited by admin on Wed Apr 02 13:17:45 GMT 2025

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USAN

KL-223

Created by admin on Wed Apr 02 13:17:45 GMT 2025 , Edited by admin on Wed Apr 02 13:17:45 GMT 2025

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NCI_THESAURUS

C203136

Created by admin on Wed Apr 02 13:17:45 GMT 2025 , Edited by admin on Wed Apr 02 13:17:45 GMT 2025

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FDA UNII

3RJ6WVX57J

Created by admin on Wed Apr 02 13:17:45 GMT 2025 , Edited by admin on Wed Apr 02 13:17:45 GMT 2025

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Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_7;1_12-1_36;2_1;2_6;2_8-2_13;2_15-2_22	48 / 58
2'-Fluoro-Ribose	1_8-1_11;2_2-2_5;2_7;2_14	10 / 58

Linkage	Site Range	Site Count
Phosporothioate	1_2;2_2-2_4;2_21-2_22	6 / 56
Phosphate	1_3-1_36;2_5-2_20	50 / 56

ACTIVE MOIETY


					3RJ6WVX57J