CUPRIC SALICYLATE TETRAHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C7H5O3.Cu.4H2O
Molecular Weight	409.833
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CUPRIC SALICYLATE TETRAHYDRATE

Structure Search

SMILES

O.O.O.O.[Cu++].OC1=CC=CC=C1C([O-])=O.OC2=CC=CC=C2C([O-])=O

InChI

InChIKey=IMGUOQFRYIAXGF-UHFFFAOYSA-L

InChI=1S/2C7H6O3.Cu.4H2O/c2*8-6-4-2-1-3-5(6)7(9)10;;;;;/h2*1-4,8H,(H,9,10);;4*1H2/q;;+2;;;;/p-2

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/367963

Cupric salicylate is an anti-inflammatory agent which was used as pain relief for patients with osteoarthritis, rheumatoid and other degenerative diseases (as a copper-salicylate complex). The preparation seem to be discontinued for now.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatic diseases 30 Sources: https://www.ncbi.nlm.nih.gov/pubmed/367963	Palliative		Approved 8429	PERMALON Approved Use Unknown

PubMed

Title	Date	PubMed
Treatment of rheumatoid and degenerative diseases with copper complexes: a review with emphasis on copper-salicylate.	1977 Sep	367963
Copper salicylate as an anti-inflammatory and analgesic agent in arthritic rats.	1983 Feb 28	6600809
Copper-salicylate gel for pain relief in osteoarthritis: a randomised controlled trial.	1997 Aug 4	9269267
The effect of ionic strength on the complexation of copper (II) with salicylate ion.	2002 May-Jun	12125457

Patents

Sample Use Guides

In Vivo Use Guide

Cupric salicylate gel (1.5 g) was applied twice daily to the forearm for four weeks. Cupric salicylate also was given as 6 and 8 intravenous infusions (60-80 mg of copper, Permalon preparation) every 3-4 days.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

CUPRIC SALICYLATE TETRAHYDRATE

Common Name

English

COPPER, BIS(SALICYLATO)-, TETRAHYDRATE

Common Name

English

BENZOIC ACID, 2-HYDROXY-, COPPER(2+) SALT (2:1), TETRAHYDRATE

Common Name

English

COPPER, BIS(2-(HYDROXY-.KAPPA.O)BENZOATO-.KAPPA.O)-, TETRAHYDRATE

Common Name

English

CUPRIC SALICYLATE TETRAHYDRATE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

3NAB6I41LP