Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H12O3 |
| Molecular Weight | 228.2433 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)OC2=CC3=C(C=CC(=O)O3)C=C2C=C1
InChI
InChIKey=QOTBQNVNUBKJMS-UHFFFAOYSA-N
InChI=1S/C14H12O3/c1-14(2)6-5-10-7-9-3-4-13(15)16-11(9)8-12(10)17-14/h3-8H,1-2H3
Xanthyletin is one of the major components of guava leaf extract (GBF), which has traditionally been used for the treatment of diarrhea and diabetes in East Asia and other countries. Recent studies have shown that GBF could reduce the metastasis of lung cancer cells and was suggested that it could be used to control the metastatic process. Xanthyletin is also an inhibitor of symbiotic fungus (Leucoagaricus gongylophorus) of leaf-cutting ant (Atta sexdens rubropilosa) and has anti-inflammatory activity; it displayed potent nitric oxide (NO)-reducing activity in microglial cells.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [On the coumarins of roots of Ruta graveolens. Xanthyletin and (-)-byak-angelicin]. | 1969 May |
|
| Anti-inflammatory principles from the stem and root barks of Citrus medica. | 2010 Jan |
|
| New benzo[c]phenanthridine and benzenoid derivatives, and other constituents from Zanthoxylum ailanthoides: Effects on neutrophil pro-inflammatory responses. | 2013 Nov 13 |
Sample Use Guides
Xanthyletin (11) exhibited potent inhibition (IC50 values ≤ 4.79 µg/mL) of superoxide anion generation by human nutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compound 11 also inhibited fMLP/CB-induced elastase release with IC50 values ≤ 5.48 µg/mL..
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3N789LD38N
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m11537
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C020814
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65188
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DTXSID60203818
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SUBSTANCE RECORD
