Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H12O3 |
| Molecular Weight | 228.2433 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)OC2=C(C=C1)C=C3C=CC(=O)OC3=C2
InChI
InChIKey=QOTBQNVNUBKJMS-UHFFFAOYSA-N
InChI=1S/C14H12O3/c1-14(2)6-5-10-7-9-3-4-13(15)16-11(9)8-12(10)17-14/h3-8H,1-2H3
| Molecular Formula | C14H12O3 |
| Molecular Weight | 228.2433 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Xanthyletin is one of the major components of guava leaf extract (GBF), which has traditionally been used for the treatment of diarrhea and diabetes in East Asia and other countries. Recent studies have shown that GBF could reduce the metastasis of lung cancer cells and was suggested that it could be used to control the metastatic process. Xanthyletin is also an inhibitor of symbiotic fungus (Leucoagaricus gongylophorus) of leaf-cutting ant (Atta sexdens rubropilosa) and has anti-inflammatory activity; it displayed potent nitric oxide (NO)-reducing activity in microglial cells.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| New benzo[c]phenanthridine and benzenoid derivatives, and other constituents from Zanthoxylum ailanthoides: Effects on neutrophil pro-inflammatory responses. | 2013-11-13 |
|
| The butanol fraction of guava (Psidium cattleianum Sabine) leaf extract suppresses MMP-2 and MMP-9 expression and activity through the suppression of the ERK1/2 MAPK signaling pathway. | 2012 |
|
| Anti-human immunodeficiency virus-1 constituents of the bark of Poncirus trifoliata. | 2010-07 |
|
| Anti-inflammatory principles from the stem and root barks of Citrus medica. | 2010-01 |
|
| Isolation of xanthyletin, an inhibitor of ants' symbiotic fungus, by high-speed counter-current chromatography. | 2009-05-08 |
|
| [On the coumarins of roots of Ruta graveolens. Xanthyletin and (-)-byak-angelicin]. | 1969-05 |
Sample Use Guides
Xanthyletin (11) exhibited potent inhibition (IC50 values ≤ 4.79 µg/mL) of superoxide anion generation by human nutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compound 11 also inhibited fMLP/CB-induced elastase release with IC50 values ≤ 5.48 µg/mL..
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:58:21 GMT 2025
by
admin
on
Mon Mar 31 19:58:21 GMT 2025
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| Record UNII |
3N789LD38N
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| Record Status |
Validated (UNII)
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| Record Version |
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m11537
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C020814
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65188
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DTXSID60203818
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