Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H12O3 |
| Molecular Weight | 228.2433 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)OC2=CC3=C(C=CC(=O)O3)C=C2C=C1
InChI
InChIKey=QOTBQNVNUBKJMS-UHFFFAOYSA-N
InChI=1S/C14H12O3/c1-14(2)6-5-10-7-9-3-4-13(15)16-11(9)8-12(10)17-14/h3-8H,1-2H3
| Molecular Formula | C14H12O3 |
| Molecular Weight | 228.2433 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Xanthyletin is one of the major components of guava leaf extract (GBF), which has traditionally been used for the treatment of diarrhea and diabetes in East Asia and other countries. Recent studies have shown that GBF could reduce the metastasis of lung cancer cells and was suggested that it could be used to control the metastatic process. Xanthyletin is also an inhibitor of symbiotic fungus (Leucoagaricus gongylophorus) of leaf-cutting ant (Atta sexdens rubropilosa) and has anti-inflammatory activity; it displayed potent nitric oxide (NO)-reducing activity in microglial cells.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [On the coumarins of roots of Ruta graveolens. Xanthyletin and (-)-byak-angelicin]. | 1969 May |
|
| Isolation of xanthyletin, an inhibitor of ants' symbiotic fungus, by high-speed counter-current chromatography. | 2009 May 8 |
|
| Anti-human immunodeficiency virus-1 constituents of the bark of Poncirus trifoliata. | 2010 Jul |
|
| The butanol fraction of guava (Psidium cattleianum Sabine) leaf extract suppresses MMP-2 and MMP-9 expression and activity through the suppression of the ERK1/2 MAPK signaling pathway. | 2012 |
Sample Use Guides
Xanthyletin (11) exhibited potent inhibition (IC50 values ≤ 4.79 µg/mL) of superoxide anion generation by human nutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compound 11 also inhibited fMLP/CB-induced elastase release with IC50 values ≤ 5.48 µg/mL..
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:50:26 GMT 2023
by
admin
on
Fri Dec 15 19:50:26 GMT 2023
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| Record UNII |
3N789LD38N
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| Record Status |
Validated (UNII)
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| Record Version |
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m11537
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C020814
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65188
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