U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C19H14F3NO
Molecular Weight 329.3158
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLURIDONE

SMILES

CN1C=C(C2=CC=CC=C2)C(=O)C(=C1)C3=CC(=CC=C3)C(F)(F)F

InChI

InChIKey=YWBVHLJPRPCRSD-UHFFFAOYSA-N
InChI=1S/C19H14F3NO/c1-23-11-16(13-6-3-2-4-7-13)18(24)17(12-23)14-8-5-9-15(10-14)19(20,21)22/h2-12H,1H3

HIDE SMILES / InChI
Fluridone, an herbicide that used for controlling invasive aquatic plants such as hydrilla in surface water bodies. It inhibits carotenoid synthesis in targeted plant species, preventing photosynthesis and ultimately causing mortality. This compound contains a 4(1H)-pyridone and a trifluoromethyl-benzene moiety, which are also present in molecules with analgesic and anti-inflammatory properties. Experiments on rodents have confirmed that fluridone could represent a new prototype of an anti-inflammatory drug.

Approval Year

PubMed

PubMed

TitleDatePubMed
Cloning and expression of a sorghum gene with homology to maize vp1. Its potential involvement in pre-harvest sprouting resistance.
2001 Apr
Downstream DNA sequences are required to modulate Pvlea-18 gene expression in response to dehydration.
2001 Mar
Bansformation of tobacco with a mutated cyanobacterial phytoene desaturase gene confers resistance to bleaching herbicides.
2002 Jul-Aug
Screening and characterization of astaxanthin-hyperproducing mutants of Haematococcus pluvialis.
2003 Apr
Activities of fructan- and sucrose-metabolizing enzymes in wheat stems subjected to water stress during grain filling.
2004 Dec
Abscisic acid in the thermoinhibition of lettuce seed germination and enhancement of its catabolism by gibberellin.
2004 Jan
The putative glutamate receptor 1.1 (AtGLR1.1) in Arabidopsis thaliana regulates abscisic acid biosynthesis and signaling to control development and water loss.
2004 Oct
Stress-responsive alpha-dioxygenase expression in tomato roots.
2005 Feb
Possible involvement of abscisic acid in the induction of secondary somatic embryogenesis on seed-coat-derived carrot somatic embryos.
2005 Jun
Post-anthesis development of inferior and superior spikelets in rice in relation to abscisic acid and ethylene.
2006
Gene expression profiles of Arabidopsis Cvi seeds during dormancy cycling indicate a common underlying dormancy control mechanism.
2006 Jun
Characterization of a higher plant herbicide-resistant phytoene desaturase and its use as a selectable marker.
2006 Mar
Dynamic analysis of ABA accumulation in relation to the rate of ABA catabolism in maize tissues under water deficit.
2007
Gene expression pattern at desiccation in the anther of Lilium longiflorum.
2007 Jul
Strigolactones: promising plant signals.
2007 May
[Study on conditions of seed germination of Cistanche].
2007 Sep
Regulatory involvement of abscisic acid in potato tuber wound-healing.
2008
Tomato strigolactones are derived from carotenoids and their biosynthesis is promoted by phosphate starvation.
2008
Involvement of ABA in induction of secondary dormancy in barley (Hordeum vulgare L.) seeds.
2008 Dec
Genome-scale cluster analysis of replicated microarrays using shrinkage correlation coefficient.
2008 Jun 18
Genetic variation for lettuce seed thermoinhibition is associated with temperature-sensitive expression of abscisic Acid, gibberellin, and ethylene biosynthesis, metabolism, and response genes.
2008 Oct
Assessment of potential aquatic herbicide impacts to California aquatic ecosystems.
2008 Oct
Roles of gibberellins and abscisic acid in dormancy and germination of red bayberry (Myrica rubra) seeds.
2008 Sep
The role of ABA in triggering ethylene biosynthesis and ripening of tomato fruit.
2009
Cloning and functional analysis of 9-cis-epoxycarotenoid dioxygenase (NCED) genes encoding a key enzyme during abscisic acid biosynthesis from peach and grape fruits.
2009 Aug 15
Abscisic acid has contrasting effects on salt excretion and polyamine concentrations of an inland and a coastal population of the Mediterranean xero-halophyte species Atriplex halimus.
2009 Oct
Identification and characterization of bZIP-type transcription factors involved in carrot (Daucus carota L.) somatic embryogenesis.
2009 Oct
Nitric oxide mediates the hormonal control of Crassulacean acid metabolism expression in young pineapple plants.
2010 Apr
Arabidopsis RING E3 ligase XBAT32 regulates lateral root production through its role in ethylene biosynthesis.
2010 Aug
Fluridone affects quiescent centre division in the Arabidopsis thaliana root stem cell niche.
2010 Dec
ABA promotes quiescence of the quiescent centre and suppresses stem cell differentiation in the Arabidopsis primary root meristem.
2010 Dec
Carotenoid inhibitors reduce strigolactone production and Striga hermonthica infection in rice.
2010 Dec 1
Fungal endophytes-induced abscisic acid is required for flavonoid accumulation in suspension cells of Ginkgo biloba.
2010 Feb
A new lead chemical for strigolactone biosynthesis inhibitors.
2010 Jul
The plant-specific SR45 protein negatively regulates glucose and ABA signaling during early seedling development in Arabidopsis.
2010 Oct
Initial characterisation of low and high seed dormancy populations of Lolium rigidum produced by repeated selection.
2010 Oct 15
Fluridone as a new anti-inflammatory drug.
2013 Nov 15
Name Type Language
FLURIDONE
HSDB   ISO  
Common Name English
1-METHYL-3-PHENYL-5-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLYL)-4-PYRIDONE
Systematic Name English
AVAST
Brand Name English
PRIDE
Brand Name English
FLURIDONE [ISO]
Common Name English
1-METHYL-3-PHENYL-5-(3-(TRIFLUOROMETHYL)PHENYL)-4(1H)-PYRIDINONE
Systematic Name English
EL-171
Code English
FLURIDONE [HSDB]
Common Name English
SONAR
Brand Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 112900
Created by admin on Fri Dec 15 18:02:42 GMT 2023 , Edited by admin on Fri Dec 15 18:02:42 GMT 2023
Code System Code Type Description
HSDB
6653
Created by admin on Fri Dec 15 18:02:42 GMT 2023 , Edited by admin on Fri Dec 15 18:02:42 GMT 2023
PRIMARY
EPA CompTox
DTXSID8024107
Created by admin on Fri Dec 15 18:02:42 GMT 2023 , Edited by admin on Fri Dec 15 18:02:42 GMT 2023
PRIMARY
CAS
59756-60-4
Created by admin on Fri Dec 15 18:02:42 GMT 2023 , Edited by admin on Fri Dec 15 18:02:42 GMT 2023
PRIMARY
FDA UNII
3L0JQA61JX
Created by admin on Fri Dec 15 18:02:42 GMT 2023 , Edited by admin on Fri Dec 15 18:02:42 GMT 2023
PRIMARY
PUBCHEM
43079
Created by admin on Fri Dec 15 18:02:42 GMT 2023 , Edited by admin on Fri Dec 15 18:02:42 GMT 2023
PRIMARY
WIKIPEDIA
Fluridone
Created by admin on Fri Dec 15 18:02:42 GMT 2023 , Edited by admin on Fri Dec 15 18:02:42 GMT 2023
PRIMARY
ECHA (EC/EINECS)
261-916-6
Created by admin on Fri Dec 15 18:02:42 GMT 2023 , Edited by admin on Fri Dec 15 18:02:42 GMT 2023
PRIMARY
ALANWOOD
fluridone
Created by admin on Fri Dec 15 18:02:42 GMT 2023 , Edited by admin on Fri Dec 15 18:02:42 GMT 2023
PRIMARY