ANTIMONY SODIUM TARTRATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C8H4O12Sb2.2Na
Molecular Weight	581.61
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].[O-]C(=O)[C@@H]1O[Sb]2O[C@H]([C@@H](O[Sb]3O[C@H]1C(=O)O3)C([O-])=O)C(=O)O2

InChI

InChIKey=UZVPADYOEPQJSP-SOMOIXMJSA-J

InChI=1S/2C4H4O6.2Na.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;/h2*1-2H,(H,7,8)(H,9,10);;;;/q2*-2;2*+1;2*+3/p-4/t2*1-,2-;;;;/m11..../s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13102586 | https://www.ncbi.nlm.nih.gov/pubmed/13715657 | https://www.drugfuture.com/chemdata/antimony-sodium-tartrate.html

Antimony sodium tartrate (stibophen) is a trivalent antimony compound having the same actions and uses as the potassium tartrate but more water-soluble and less irritant when injected. Antimony sodium tartrate has been used in the treatment of Schistosomiasis since 1918. It is a toxic drug and may cause unpleasant side-effects.This drug is now rarely used in the therapy of leishmaniasis, as drugs which are much better tolerated are available

Approval Year

PubMed

Title	Date	PubMed
The intensive treatment of schistosomiasis with sodium antimony tartrate; a report on 200 cases.	1953 Sep	13102586
The effects of sodium antimony tartrate on the myocardium.	1960 Nov	13715657
Clinically available antischistosomal drugs.	1975 Nov	1206768

Patents

Sample Use Guides

In Vivo Use Guide

Schistosomiasis : For adults two grains of sodium antimony tartrate were dissolved in 20 c.c. of 5 per cent. glucose, and slowly injected intravenously through a 16-gauge needle--children were given doses according to their weights, taking 60 kg as adult weight.

Route of Administration: Intravenous

In Vitro Use Guide

In Ascaridia galli antimony sodium tartrate (stibophen) turned out to be a potent inhibitor of phosvitin kinase I; the inhibition constant was determined to be 10 uM.

Name

Type

Language

ANTIMONY SODIUM TARTRATE

Systematic Name

English

SODIUM AQUA(TARTRATO(4-)-O1,O2,O3)ANTIMONIATE(III) [WHO-IP]

Common Name

English

ANTIMONATE(2-), BIS(.MU.-(2,3-DIHYDROXYBUTANEDIOATO(4-)-O1,O2:O3,O4))DI-, DISODIUM, STEREOISOMER

Common Name

English

ANTIMONY SODIUM TARTRATE [USP IMPURITY]

Common Name

English

STIBII NATRII TARTRAS [WHO-IP LATIN]

Common Name

English

ANTIMONY SODIUM TARTRATE [WHO-IP]

Common Name

English

DISODIUM BIS(.MU.-(L-(+)-TARTRATO(4-)))DIANTIMONATE(2-)

Common Name

English

ANTIMONY SODIUM TARTRATE [JAN]

Common Name

English

ANTIMONY SODIUM TARTRATE [MI]

Common Name

English

Antimony sodium tartrate [WHO-DD]

Common Name

English

ANTIMONY SODIUM TARTRATE [MART.]

Common Name

English

Code System Code Type Description

PUBCHEM

73995019