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Details

Stereochemistry ABSOLUTE
Molecular Formula C8H4O12Sb2.2Na
Molecular Weight 581.61
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ANTIMONY SODIUM TARTRATE

SMILES

[Na+].[Na+].[O-]C(=O)[C@@H]1O[Sb]2O[C@H]([C@@H](O[Sb]3O[C@H]1C(=O)O3)C([O-])=O)C(=O)O2

InChI

InChIKey=UZVPADYOEPQJSP-SOMOIXMJSA-J
InChI=1S/2C4H4O6.2Na.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;/h2*1-2H,(H,7,8)(H,9,10);;;;/q2*-2;2*+1;2*+3/p-4/t2*1-,2-;;;;/m11..../s1

HIDE SMILES / InChI

Description

Antimony sodium tartrate (stibophen) is a trivalent antimony compound having the same actions and uses as the potassium tartrate but more water-soluble and less irritant when injected. Antimony sodium tartrate has been used in the treatment of Schistosomiasis since 1918. It is a toxic drug and may cause unpleasant side-effects.This drug is now rarely used in the therapy of leishmaniasis, as drugs which are much better tolerated are available

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
Schistosomiasis : For adults two grains of sodium antimony tartrate were dissolved in 20 c.c. of 5 per cent. glucose, and slowly injected intravenously through a 16-gauge needle--children were given doses according to their weights, taking 60 kg as adult weight.
Route of Administration: Intravenous
In Vitro Use Guide
In Ascaridia galli antimony sodium tartrate (stibophen) turned out to be a potent inhibitor of phosvitin kinase I; the inhibition constant was determined to be 10 uM.