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Details

Stereochemistry ABSOLUTE
Molecular Formula C8H4O12Sb2.2Na
Molecular Weight 581.61
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ANTIMONY SODIUM TARTRATE

SMILES

[Na+].[Na+].[O-]C(=O)[C@@H]1O[Sb]2O[C@H]([C@@H](O[Sb]3O[C@H]1C(=O)O3)C([O-])=O)C(=O)O2

InChI

InChIKey=UZVPADYOEPQJSP-SOMOIXMJSA-J
InChI=1S/2C4H4O6.2Na.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;/h2*1-2H,(H,7,8)(H,9,10);;;;/q2*-2;2*+1;2*+3/p-4/t2*1-,2-;;;;/m11..../s1

HIDE SMILES / InChI
Molecular Formula C8H4O12Sb2
Molecular Weight 535.63
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Antimony sodium tartrate (stibophen) is a trivalent antimony compound having the same actions and uses as the potassium tartrate but more water-soluble and less irritant when injected. Antimony sodium tartrate has been used in the treatment of Schistosomiasis since 1918. It is a toxic drug and may cause unpleasant side-effects.This drug is now rarely used in the therapy of leishmaniasis, as drugs which are much better tolerated are available

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Clinically available antischistosomal drugs.
1975 Nov
Patents

Patents

US3342844A
2
US3728367A
1
US4499003
1

Sample Use Guides

In Vivo Use Guide
Schistosomiasis : For adults two grains of sodium antimony tartrate were dissolved in 20 c.c. of 5 per cent. glucose, and slowly injected intravenously through a 16-gauge needle--children were given doses according to their weights, taking 60 kg as adult weight.
Route of Administration: Intravenous
In Vitro Use Guide
In Ascaridia galli antimony sodium tartrate (stibophen) turned out to be a potent inhibitor of phosvitin kinase I; the inhibition constant was determined to be 10 uM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:56:56 GMT 2023
Edited
by admin
on Fri Dec 15 18:56:56 GMT 2023
Record UNII
3KUI0LP48L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ANTIMONY SODIUM TARTRATE
JAN   MART.   MI   USP   WHO-DD   WHO-IP  
Systematic Name English
SODIUM AQUA(TARTRATO(4-)-O1,O2,O3)ANTIMONIATE(III) [WHO-IP]
Common Name English
ANTIMONATE(2-), BIS(.MU.-(2,3-DIHYDROXYBUTANEDIOATO(4-)-O1,O2:O3,O4))DI-, DISODIUM, STEREOISOMER
Common Name English
ANTIMONY SODIUM TARTRATE [USP IMPURITY]
Common Name English
STIBII NATRII TARTRAS [WHO-IP LATIN]
Common Name English
ANTIMONY SODIUM TARTRATE [WHO-IP]
Common Name English
DISODIUM BIS(.MU.-(L-(+)-TARTRATO(4-)))DIANTIMONATE(2-)
Common Name English
ANTIMONY SODIUM TARTRATE [JAN]
Common Name English
ANTIMONY SODIUM TARTRATE [MI]
Common Name English
Antimony sodium tartrate [WHO-DD]
Common Name English
ANTIMONY SODIUM TARTRATE [MART.]
Common Name English
Code System Code Type Description
PUBCHEM
73995019
Created by admin on Fri Dec 15 18:56:56 GMT 2023 , Edited by admin on Fri Dec 15 18:56:56 GMT 2023
PRIMARY
MERCK INDEX
m1963
Created by admin on Fri Dec 15 18:56:56 GMT 2023 , Edited by admin on Fri Dec 15 18:56:56 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID90956042
Created by admin on Fri Dec 15 18:56:56 GMT 2023 , Edited by admin on Fri Dec 15 18:56:56 GMT 2023
PRIMARY
CAS
34521-09-0
Created by admin on Fri Dec 15 18:56:56 GMT 2023 , Edited by admin on Fri Dec 15 18:56:56 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
ANTIMONY SODIUM TARTRATE
Created by admin on Fri Dec 15 18:56:56 GMT 2023 , Edited by admin on Fri Dec 15 18:56:56 GMT 2023
PRIMARY Description: Colourless, transparent scales or an almost white powder; odourless. Solubility: Soluble in 1.5 parts of water; practically insoluble in ethanol (~750 g/l) TS. Category: Antischistosomal drug. Storage: Antimony sodium tartrate should be kept in a tightly closed container, protected from light. Additional information: Antimony sodium tartrate is hygroscopic. Even in the absence of light, it is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures. Definition: Antimony sodium tartrate contains not less than 98.0% and not more than 101.0% of C4H4NaO7Sb, calculated with reference to the dried substance.
FDA UNII
3KUI0LP48L
Created by admin on Fri Dec 15 18:56:56 GMT 2023 , Edited by admin on Fri Dec 15 18:56:56 GMT 2023
PRIMARY
MESH
C026019
Created by admin on Fri Dec 15 18:56:56 GMT 2023 , Edited by admin on Fri Dec 15 18:56:56 GMT 2023
PRIMARY
ECHA (EC/EINECS)
252-070-9
Created by admin on Fri Dec 15 18:56:56 GMT 2023 , Edited by admin on Fri Dec 15 18:56:56 GMT 2023
PRIMARY
CHEBI
31224
Created by admin on Fri Dec 15 18:56:56 GMT 2023 , Edited by admin on Fri Dec 15 18:56:56 GMT 2023
PRIMARY
NIH
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