DescriptionSources: http://www.accessdata.fda.gov/spl/data/34edbae8-e952-4908-a425-b9f029bb4502/34edbae8-e952-4908-a425-b9f029bb4502.xmlCurator's Comment: Description was created based on several sources, including https://www.drugs.com/monograph/senna.html and http://www.drugbank.ca/drugs/DB11365
Sources: http://www.accessdata.fda.gov/spl/data/34edbae8-e952-4908-a425-b9f029bb4502/34edbae8-e952-4908-a425-b9f029bb4502.xml
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/monograph/senna.html and http://www.drugbank.ca/drugs/DB11365
Sennosides are hydroxyanthracene glycosides derived from Senna leaves. They have been used as natural, safe time-tested laxatives in traditional as well as modern systems of medicine. Sennosides (Senna) is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil. Senna is an FDA-approved nonprescription drug for adults and children ages 2 years and older. It is also used for bowel preparation before colonoscopy and diagnostic imaging.
Originator
Sources: https://www.drugs.com/npp/senna.html
Curator's Comment: Senna was first used medicinally by Arabian physicians in the 9th century A.D.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2095173 Sources: http://www.ncbi.nlm.nih.gov/pubmed/11218732 |
680.0 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | SENNA Approved UseRelieves occasional constipation (irregularity) Launch Date2012 |
Sample Use Guides
Adults and children 12 years of age or older - 2 tablets once a day starting dose; 4 tablets twice a day maximal dose; children 6 to under 12 years - 1 tablet once a day starting dose; 2 tablets twice a day maximal dose; each Senna Tablet contains: Sennosides 8.6 mg / Standardized Senna Concentrate
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/8010034
Sennosides (20 mmol/l) induced spontaneous spike potentials in guinea pig taenia coli.
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1162 (Number of products:8)
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A06AB56
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C29697
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DB11365
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1612007
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CHEMBL2108559
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ACTIVE MOIETY
SUBSTANCE RECORD