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Details

Stereochemistry RACEMIC
Molecular Formula C8H19NO
Molecular Weight 145.2426
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HEPTAMINOL

SMILES

CC(N)CCCC(C)(C)O

InChI

InChIKey=LREQLEBVOXIEOM-UHFFFAOYSA-N
InChI=1S/C8H19NO/c1-7(9)5-4-6-8(2,3)10/h7,10H,4-6,9H2,1-3H3

HIDE SMILES / InChI

Description

Heptaminol is an amino alcohol that has been used as a myocardial stimulant and vasodilator and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
15.3 µM [IC50]
60.0 µM [Ki]
650.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Corasore

PubMed

Sample Use Guides

In Vivo Use Guide
Infants & children under 12 years: 4-16 drops (25 -100 mg) depending on age, 2 – 4 times daily, up to 6 times daily if necessary, or as directed by the physician. Adults & children over 12 years: One tablet or 25 drops, (150 mg) 2-4 times daily, up to 6 times daily.
Route of Administration: Oral
In Vitro Use Guide
1. The effects of heptaminol on calcium current amplitude and characteristics were studied in single ventricular myocytes of guinea-pig by use of the whole cell configuration of the patch clamp technique. 2. A concentration-dependent decrease in ICa amplitude was observed. At heptaminol concentration as low as 10(-6) M, this effect was observed in only two cells (n = 6). At 10(-5) M the reduction of ICa was of 30 +/- 15% (n = 11). Both at -40 mV and -80 mV HP, heptaminol (10(-5) M) significantly increased the steady state inactivation of ICa.