HEPTAMINOL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C8H19NO.ClH
Molecular Weight	181.703
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(N)CCCC(C)(C)O

InChI

InChIKey=JZNBMCOSOXIZJB-UHFFFAOYSA-N

InChI=1S/C8H19NO.ClH/c1-7(9)5-4-6-8(2,3)10;/h7,10H,4-6,9H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	C8H19NO
Molecular Weight	145.2426
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500014397.pdf | https://www.ncbi.nlm.nih.gov/pubmed/1929117 | https://www.ncbi.nlm.nih.gov/mesh/68006535

Heptaminol is an amino alcohol that has been used as a myocardial stimulant and vasodilator and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Voltage-dependent L-type calcium channel subunit alpha-1C 4 Target ID: CHEMBL2366456 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22761000	Inhibitor 8297	15.3 µM [IC50]
norepinephrine uptake 18 Target ID: GO:0051620 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2386550	Inhibitor 8297	60.0 µM [Ki]
catecholamine uptake 2 Target ID: GO:0090493 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2386550	Inhibitor 8297	650.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypotension 28 Sources: http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500014397.pdf https://www.tabletwise.com/medicine/heptaminol	Primary		Approved 8429	Corasore Approved Use Is for the treatment of hypotension, fainting tendency and slight to moderately severe circulatory collapse; Asthenia, nervous and physical fatigue in general and sporting medicine; Adjuvant treatment of mild and moderate cases of heart failure particularly incipient pulmonary edema; Heart failure associated with toxic, infectious, degenerative orarteriosclerotic myocardial disease; Neonatal asphyxia.

PubMed

Title	Date	PubMed
Randomized double-blind trial of injectable heptaminol for controlling spontaneous or bromocriptine-induced orthostatic hypotension in parkinsonians.	1990	2096108
Heptaminol interferes in the AxSYM FPIA amphetamine/methamphetamine II assay.	2001 Aug	11468252
Metabolism of isometheptene in human urine and analysis by gas chromatography-mass spectrometry in doping control.	2005 Dec 5	16242387
Solid-phase column chromatographic and gas chromatographic-mass spectrometric determination of heptaminol in human urine and related pharmacokinetic profiles.	2006 Jul-Aug	16872566
Hair lightening in an hemodialysis patient treated by heptaminol (heptamyl).	2009 Apr 15	19450409

Patents

Sample Use Guides

In Vivo Use Guide

Infants & children under 12 years: 4-16 drops (25 -100 mg) depending on age, 2 – 4 times daily, up to 6 times daily if necessary, or as directed by the physician. Adults & children over 12 years: One tablet or 25 drops, (150 mg) 2-4 times daily, up to 6 times daily.

Route of Administration: Oral

In Vitro Use Guide

1. The effects of heptaminol on calcium current amplitude and characteristics were studied in single ventricular myocytes of guinea-pig by use of the whole cell configuration of the patch clamp technique. 2. A concentration-dependent decrease in ICa amplitude was observed. At heptaminol concentration as low as 10(-6) M, this effect was observed in only two cells (n = 6). At 10(-5) M the reduction of ICa was of 30 +/- 15% (n = 11). Both at -40 mV and -80 mV HP, heptaminol (10(-5) M) significantly increased the steady state inactivation of ICa.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 07:38:23 UTC 2023` Edited by `admin` on `Sat Dec 16 07:38:23 UTC 2023`
Record UNII	XB3RM40HIR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HEPTAMINOL HYDROCHLORIDE

Common Name

English

HEPTAMYL HYDROCHLORIDE

Systematic Name

English

IZOKTAMIL

Brand Name

English

Heptaminol hydrochloride [WHO-DD]

Common Name

English

2-METHYL-6-AMINO-2-HEPTANOL HYDROCHLORIDE

Systematic Name

English

HEPTAMINOL HYDROCHLORIDE [MART.]

Common Name

English

HEPTYLON

Brand Name

English

2831RP

Code

English

CORTENSOR

Brand Name

English

HEPTAMINOL HYDROCHLORIDE [MI]

Common Name

English

2-HEPTANOL, 6-AMINO-2-METHYL-, HYDROCHLORIDE

Systematic Name

English

CORASOR

Brand Name

English

6-METHYL-2-AMINO-6-HEPTANOL HYDROCHLORIDE

Systematic Name

English

RP 2831

Code

English

CARDIOSINTOL

Common Name

English

EODEN

Brand Name

English

RP-2831

Code

English

HEPTAMINOL HYDROCHLORIDE [EP MONOGRAPH]

Common Name

English

2-HEPTANOL, 6-AMINO-2-METHYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

RESPIRIN

Brand Name

English

6-AMINO-2-METHYL-2-HEPTANOL HYDROCHLORIDE

Systematic Name

English

HEPTAMYL

Common Name

English

NSC-758406

Code

English

6-AMINO-2-METHYL-HEPTAN-2-OL HYDROCHLORIDE

Systematic Name

English

ISOKTAMIL

Brand Name

English

Code System Code Type Description

EVMPD

SUB02489MIG