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Details

Stereochemistry RACEMIC
Molecular Formula C8H19NO.ClH
Molecular Weight 181.7037
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HEPTAMINOL HYDROCHLORIDE

SMILES

CC(CCCC(C)(C)O)N.Cl

InChI

InChIKey=JZNBMCOSOXIZJB-UHFFFAOYSA-N
InChI=1S/C8H19NO.ClH/c1-7(9)5-4-6-8(2,3)10;/h7,10H,4-6,9H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula C8H19NO
Molecular Weight 145.2429
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula ClH
Molecular Weight 36.4609
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Heptaminol is an amino alcohol that has been used as a myocardial stimulant and vasodilator and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.

CNS Activity

Curator's Comment:: Heptaminol (Corasore®) is a cardiac stimulant having a positive inotropic action. It increases coronary blood flow with a slight peripheral vasoconstrictor properties and mild C.N.S. stimulant effect.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
15.3 µM [IC50]
60.0 µM [Ki]
650.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Corasore

Approved Use

Is for the treatment of hypotension, fainting tendency and slight to moderately severe circulatory collapse; Asthenia, nervous and physical fatigue in general and sporting medicine; Adjuvant treatment of mild and moderate cases of heart failure particularly incipient pulmonary edema; Heart failure associated with toxic, infectious, degenerative orarteriosclerotic myocardial disease; Neonatal asphyxia.
PubMed

PubMed

TitleDatePubMed
Randomized double-blind trial of injectable heptaminol for controlling spontaneous or bromocriptine-induced orthostatic hypotension in parkinsonians.
1990
Heptaminol interferes in the AxSYM FPIA amphetamine/methamphetamine II assay.
2001 Aug
Clinical study of the Ginko biloba--Troxerutin-Heptaminol Hce in the treatment of acute hemorrhoidal attacks.
2004 Feb
Metabolism of isometheptene in human urine and analysis by gas chromatography-mass spectrometry in doping control.
2005 Dec 5
Adverse drug reactions related to drugs used in orthostatic hypotension: a prospective and systematic pharmacovigilance study in France.
2005 Jul
Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure.
2005 Sep
Solid-phase column chromatographic and gas chromatographic-mass spectrometric determination of heptaminol in human urine and related pharmacokinetic profiles.
2006 Jul-Aug
Hair lightening in an hemodialysis patient treated by heptaminol (heptamyl).
2009 Apr 15
Patents

Sample Use Guides

Infants & children under 12 years: 4-16 drops (25 -100 mg) depending on age, 2 – 4 times daily, up to 6 times daily if necessary, or as directed by the physician. Adults & children over 12 years: One tablet or 25 drops, (150 mg) 2-4 times daily, up to 6 times daily.
Route of Administration: Oral
In Vitro Use Guide
1. The effects of heptaminol on calcium current amplitude and characteristics were studied in single ventricular myocytes of guinea-pig by use of the whole cell configuration of the patch clamp technique. 2. A concentration-dependent decrease in ICa amplitude was observed. At heptaminol concentration as low as 10(-6) M, this effect was observed in only two cells (n = 6). At 10(-5) M the reduction of ICa was of 30 +/- 15% (n = 11). Both at -40 mV and -80 mV HP, heptaminol (10(-5) M) significantly increased the steady state inactivation of ICa.
Substance Class Chemical
Created
by admin
on Fri Jun 25 21:12:37 UTC 2021
Edited
by admin
on Fri Jun 25 21:12:37 UTC 2021
Record UNII
XB3RM40HIR
Record Status Validated (UNII)
Record Version
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Name Type Language
HEPTAMINOL HYDROCHLORIDE
EP   MART.   MI   WHO-DD  
Common Name English
HEPTAMINOL HYDROCHLORIDE [WHO-DD]
Common Name English
HEPTAMYL HYDROCHLORIDE
Systematic Name English
IZOKTAMIL
Brand Name English
2-METHYL-6-AMINO-2-HEPTANOL HYDROCHLORIDE
Systematic Name English
HEPTAMINOL HYDROCHLORIDE [MART.]
Common Name English
HEPTYLON
Brand Name English
2831RP
Code English
CORTENSOR
Brand Name English
HEPTAMINOL HYDROCHLORIDE [MI]
Common Name English
2-HEPTANOL, 6-AMINO-2-METHYL-, HYDROCHLORIDE
Systematic Name English
CORASOR
Brand Name English
6-METHYL-2-AMINO-6-HEPTANOL HYDROCHLORIDE
Systematic Name English
RP 2831
Code English
CARDIOSINTOL
Common Name English
EODEN
Brand Name English
RP-2831
Code English
HEPTAMINOL HYDROCHLORIDE [EP MONOGRAPH]
Common Name English
2-HEPTANOL, 6-AMINO-2-METHYL-, HYDROCHLORIDE (1:1)
Systematic Name English
RESPIRIN
Brand Name English
6-AMINO-2-METHYL-2-HEPTANOL HYDROCHLORIDE
Systematic Name English
HEPTAMYL
Common Name English
NSC-758406
Code English
6-AMINO-2-METHYL-HEPTAN-2-OL HYDROCHLORIDE
Systematic Name English
ISOKTAMIL
Brand Name English
Code System Code Type Description
EVMPD
SUB02489MIG
Created by admin on Fri Jun 25 21:12:37 UTC 2021 , Edited by admin on Fri Jun 25 21:12:37 UTC 2021
PRIMARY
ChEMBL
CHEMBL2111076
Created by admin on Fri Jun 25 21:12:37 UTC 2021 , Edited by admin on Fri Jun 25 21:12:37 UTC 2021
PRIMARY
EPA CompTox
543-15-7
Created by admin on Fri Jun 25 21:12:37 UTC 2021 , Edited by admin on Fri Jun 25 21:12:37 UTC 2021
PRIMARY
PUBCHEM
10969
Created by admin on Fri Jun 25 21:12:37 UTC 2021 , Edited by admin on Fri Jun 25 21:12:37 UTC 2021
PRIMARY
CAS
543-15-7
Created by admin on Fri Jun 25 21:12:37 UTC 2021 , Edited by admin on Fri Jun 25 21:12:37 UTC 2021
PRIMARY
FDA UNII
XB3RM40HIR
Created by admin on Fri Jun 25 21:12:37 UTC 2021 , Edited by admin on Fri Jun 25 21:12:37 UTC 2021
PRIMARY
ECHA (EC/EINECS)
208-837-5
Created by admin on Fri Jun 25 21:12:37 UTC 2021 , Edited by admin on Fri Jun 25 21:12:37 UTC 2021
PRIMARY
MERCK INDEX
M5962
Created by admin on Fri Jun 25 21:12:37 UTC 2021 , Edited by admin on Fri Jun 25 21:12:37 UTC 2021
PRIMARY Merck Index
RXCUI
236294
Created by admin on Fri Jun 25 21:12:37 UTC 2021 , Edited by admin on Fri Jun 25 21:12:37 UTC 2021
PRIMARY RxNorm
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