Details
Stereochemistry | RACEMIC |
Molecular Formula | C22H28N |
Molecular Weight | 306.4644 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 1 |
SHOW SMILES / InChI
SMILES
CC[N+]1(CC)CCC(C1C)=C(C2=CC=CC=C2)C3=CC=CC=C3
InChI
InChIKey=ZYEPZINLLPPBMI-UHFFFAOYSA-N
InChI=1S/C22H28N/c1-4-23(5-2)17-16-21(18(23)3)22(19-12-8-6-9-13-19)20-14-10-7-11-15-20/h6-15,18H,4-5,16-17H2,1-3H3/q+1
DescriptionCurator's Comment: description was created based on several sources, including http://www.rlsnet.ru/tn_index_id_6544.htm
Curator's Comment: description was created based on several sources, including http://www.rlsnet.ru/tn_index_id_6544.htm
Prifinium bromide is antimuscarinic drug, which has antispasmodic, antiemetic effect. Prifinium bromideis approved for pain relief in Russia, Indonesia, Iraq, Tunisia and other countries.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2094109 Sources: http://www.genome.jp/dbget-bin/www_bget?D01377 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Reyabal Approved UsePain due to spasm and hypermotility of the gastrointestinal tract: gastritis, gastroduodenal ulcer, enteritis, colitis, post-gastrectomy syndrome and irritable colon. Pain due to spasm and dyskinesia of the bile duct cholecystitis, and choleithiasis. Pain due to pancreatitis. Pain due to spasm of urinary tract, lithureteria, vesical tenesmus, cystitis and pyelitis. |
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Secondary | Reyabal Approved UsePremedication for gastric endoscopy and gastrointestinal radiography. |
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Sources: http://www.rlsnet.ru/tn_index_id_6544.htm |
Primary | Riabal Approved UseVomiting (functional spasms in infants and children after feeding, with acute gastroenteritis, febrile conditions, with intracranial hypertension, after radiation therapy, with intolerance of medicines). |
PubMed
Title | Date | PubMed |
---|---|---|
Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. | 2008 Nov 13 |
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Risk management for gastrointestinal endoscopy in elderly patients: questionnaire for patients undergoing gastrointestinal endoscopy. | 2010 Jan |
Patents
Sample Use Guides
Tablets of Reyabal, containing 325 mg Paracetamol and 30 mg Prifinium bromide, are indicated against pain 1-2 tablets a day.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5299979
Prifinium bromide depressed the amplitude of muscle contraction induced by electrical stimulation of the phrenic nerve at a concentration of 50 ug/ml, while large concentrations of 100 ug/ml produced no change on muscle contraction induced by direct stimulation of the muscle.
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NCI_THESAURUS |
C66880
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DB13254
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SUB04037MIG
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C84105
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4905
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236174
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C084641
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)