PRIFINIUM BROMIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H28N.Br
Molecular Weight	386.368
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Br-].CC[N+]1(CC)CCC(C1C)=C(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=UCGJZJXOPSNTGZ-UHFFFAOYSA-M

InChI=1S/C22H28N.BrH/c1-4-23(5-2)17-16-21(18(23)3)22(19-12-8-6-9-13-19)20-14-10-7-11-15-20;/h6-15,18H,4-5,16-17H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula	BrH
Molecular Weight	80.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C22H28N
Molecular Weight	306.4644
Charge	1
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.drugs.com/international/prifinium-bromide.html
Curator's Comment: description was created based on several sources, including http://www.rlsnet.ru/tn_index_id_6544.htm

Prifinium bromide is antimuscarinic drug, which has antispasmodic, antiemetic effect. Prifinium bromideis approved for pain relief in Russia, Indonesia, Iraq, Tunisia and other countries.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 160 Target ID: CHEMBL2094109 Sources: http://www.genome.jp/dbget-bin/www_bget?D01377	Antagonist 2778

Conditions

Condition	Modality	Highest Phase	Product
Pain 614 Sources: http://www.kpiraq.com/wp-content/files_mf/1425803795LefleatRiabal.pdf	Primary	Approved 8429	Reyabal Approved Use Pain due to spasm and hypermotility of the gastrointestinal tract: gastritis, gastroduodenal ulcer, enteritis, colitis, post-gastrectomy syndrome and irritable colon. Pain due to spasm and dyskinesia of the bile duct cholecystitis, and choleithiasis. Pain due to pancreatitis. Pain due to spasm of urinary tract, lithureteria, vesical tenesmus, cystitis and pyelitis.
Gastric endoscopy 2 Sources: http://www.kpiraq.com/wp-content/files_mf/1425803795LefleatRiabal.pdf	Secondary	Approved 8429	Reyabal Approved Use Premedication for gastric endoscopy and gastrointestinal radiography.
Vomiting 38 Sources: http://www.rlsnet.ru/tn_index_id_6544.htm	Primary	Approved 8429	Riabal Approved Use Vomiting (functional spasms in infants and children after feeding, with acute gastroenteritis, febrile conditions, with intracranial hypertension, after radiation therapy, with intolerance of medicines).

PubMed

Title	Date	PubMed
Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis.	2008 Nov 13	19008265

Patents

Sample Use Guides

In Vivo Use Guide

Tablets of Reyabal, containing 325 mg Paracetamol and 30 mg Prifinium bromide, are indicated against pain 1-2 tablets a day.

Route of Administration: Oral

In Vitro Use Guide

Prifinium bromide depressed the amplitude of muscle contraction induced by electrical stimulation of the phrenic nerve at a concentration of 50 ug/ml, while large concentrations of 100 ug/ml produced no change on muscle contraction induced by direct stimulation of the muscle.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:16:08 GMT 2023` Edited by `admin` on `Sat Dec 16 16:16:08 GMT 2023`
Record UNII	3B7O9ZC520
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PRIFINIUM BROMIDE

Official Name

English

PYRROLIDINIUM, 3-(DIPHENYLMETHYLENE)-1,1-DIETHYL-2-METHYL-, BROMIDE (1:1)

Systematic Name

English

PRIFINIUM BROMIDE [MART.]

Common Name

English

3-(DIPHENYLMETHYLENE)-1-ETHYL-2-METHYLPYRROLIDINE ETHYL BROMIDE

Systematic Name

English

PADRIN

Brand Name

English

prifinium bromide [INN]

Common Name

English

PRIFINIUM BROMIDE [MI]

Common Name

English

PYRROLIDINIUM, 3-(DIPHENYLMETHYLENE)-1,1-DIETHYL-2-METHYL-, BROMIDE

Systematic Name

English

Prifinium bromide [WHO-DD]

Common Name

English

PDB

Code

English

RIABAL

Brand Name

English

PRIFINIUM BROMIDE [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66880