Stereochemistry | ACHIRAL |
Molecular Formula | C20H15NO3 |
Molecular Weight | 317.338 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C(C=C1)C2(C(=O)NC3=CC=CC=C23)C4=CC=C(O)C=C4
InChI
InChIKey=SJDACOMXKWHBOW-UHFFFAOYSA-N
InChI=1S/C20H15NO3/c22-15-9-5-13(6-10-15)20(14-7-11-16(23)12-8-14)17-3-1-2-4-18(17)21-19(20)24/h1-12,22-23H,(H,21,24)
Oxyphenisatin is a stimulant laxative that has been used by mouth and as an enema. Oxyphenisatin was introduced as Lavema by Winthrop in US in 1959. Oxyphenisatin was used as a cleansing enema apart
from x-ray studies and prior to urinary, gastro-intestinal and
cholecystography x-ray examination. Oxyphenisatin was also used for preoperative preparation of the large intestine and colon. May be mixed with
barium for x-ray examination of the large intestine.
Oxyphenisatin may cause jaundice. Oxyphenisatin-induced liver damage usually occurs when the
drug has been taken for at least six months and usually two years. Oxyphenisatin was withdrawn in most countries in the early 1970s.
Originator
Approval Year
Doses
AEs
Sourcing
PubMed
Patents
Sample Use Guides
Cleansing enema: Lavema (Oxyphenisatin) in a dosage
of from 1.5 to 3 g. should be thoroughly mixed in 1 to 2
quarts of water. Radiopaque (barium) enema adjuvant:
Lavema in a dosage of from 1.5 to 3 g. should be added to the usu-al 1 to 2 quarts of barium enema suspension and
well mixed, preferably in an electric mixer, to obtain uniform
dispersion (1/2 packet for elderly and debilitated patients).
Route of Administration:
Other