Details
Stereochemistry | ACHIRAL |
Molecular Formula | C11H14N4O2 |
Molecular Weight | 234.2545 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(C)=NN1C2=NC(OC)=CC(C)=N2
InChI
InChIKey=RHAXSHUQNIEUEY-UHFFFAOYSA-N
InChI=1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3
Epirizole (also known as Mepirizole) is a nonsteroidal anti-inflammatory drug developed for the treatment of such conditions as chronic rheumatoid arthritis. Although the drug was tested in a clinical trial, its current status is unknown and is supposed to be discontinued. Epirizole is known to be a duodenal ulcerogen, and its effect is mediated by generation of ROS.
Approval Year
PubMed
Title | Date | PubMed |
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Synthesis, crystal structure, magnetic properties, and theoretical studies of [(Cu(mepirizole)Br)2(mu-OH)(mu-pz)] (mepirizole=4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine; pz=pyrazolate), a novel mu-pyrazolato-mu-hydroxo-dibridged copper(II) complex. | 2003 Dec 15 |
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Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats. | 2004 |
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NCI_THESAURUS |
C257
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ACTIVE MOIETY