U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ACHIRAL
Molecular Formula C11H14N4O2
Molecular Weight 234.2545
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EPIRIZOLE

SMILES

COC1=CC(C)=NN1C2=NC(C)=CC(OC)=N2

InChI

InChIKey=RHAXSHUQNIEUEY-UHFFFAOYSA-N
InChI=1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3

HIDE SMILES / InChI

Description

Epirizole (also known as Mepirizole) is a nonsteroidal anti-inflammatory drug developed for the treatment of such conditions as chronic rheumatoid arthritis. Although the drug was tested in a clinical trial, its current status is unknown and is supposed to be discontinued. Epirizole is known to be a duodenal ulcerogen, and its effect is mediated by generation of ROS.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Unknown

Cmax

ValueDoseCo-administeredAnalytePopulation
0.8 μg/mL
200 mg single, oral
EPIRIZOLE serum
Homo sapiens

Doses

AEs

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown