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Details

Stereochemistry ACHIRAL
Molecular Formula C13H10O7
Molecular Weight 278.2143
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EXIFONE

SMILES

OC1=CC=C(C(=O)C2=CC(O)=C(O)C(O)=C2)C(O)=C1O

InChI

InChIKey=XEDWWPGWIXPVRQ-UHFFFAOYSA-N
InChI=1S/C13H10O7/c14-7-2-1-6(11(18)13(7)20)10(17)5-3-8(15)12(19)9(16)4-5/h1-4,14-16,18-20H

HIDE SMILES / InChI

Description

Exifone, a drug recently proposed for the treatment of cognitive deficiencies of old age, has been marketed in France beginning in April 1988. It demonstrated remarkable anti-radical properties, but was withdrawal, because of the hepatotoxicity.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Adlone
PubMed

PubMed

TitleDatePubMed
The effects of exifone, a new agent for senile memory disorder, on two models of memory in the mouse.
1987 Jun
[A case of hepatitis caused by exifone and bezafibrate].
1989 Apr
The neuroprotective activity of 8-alkylamino-1,4-benzoxazine antioxidants.
2001 Jul 27
Synergistic antimalarial activity of ketones with rufigallol and vitamin C.
2005 Oct
A convenient approach for evaluating the toxicity profiles of in vitro neuroprotective alkylaminophenol derivatives.
2006 Mar 1
A cellular model to monitor proteasome dysfunction by alpha-synuclein.
2009 Aug 25
Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding.
2010 Jan 22
Patents

Patents

Sample Use Guides

In Vivo Use Guide
600 and 1200 mg/d
Route of Administration: Oral
Name Type Language
EXIFONE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
2,3,3',4,4',5-HEXAHYDROXY-BENZOPHENONE
Systematic Name English
EXIFONE [WHO-DD]
Common Name English
EXIFONE [MI]
Common Name English
EXIFONE [MART.]
Common Name English
NSC-680919
Code English
EXIFONE [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1327
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
Code System Code Type Description
PUBCHEM
40399
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
PRIMARY
EPA CompTox
52479-85-3
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
PRIMARY
MESH
C052932
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
PRIMARY
MERCK INDEX
M1149
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
PRIMARY Merck Index
ECHA (EC/EINECS)
257-945-9
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
PRIMARY
INN
4649
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
PRIMARY
NCI_THESAURUS
C81567
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
PRIMARY
EVMPD
SUB07494MIG
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
PRIMARY
CAS
52479-85-3
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
PRIMARY
ChEMBL
CHEMBL329522
Created by admin on Tue Oct 22 06:20:15 UTC 2019 , Edited by admin on Tue Oct 22 06:20:15 UTC 2019
PRIMARY