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Details

Stereochemistry ACHIRAL
Molecular Formula C16H14O4
Molecular Weight 270.28
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of ECHINATIN

SMILES

COC1=CC(O)=CC=C1\C=C\C(=O)C2=CC=C(O)C=C2

InChI

InChIKey=QJKMIJNRNRLQSS-WEVVVXLNSA-N
InChI=1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+

HIDE SMILES / InChI
Echinatin is a component of Glycyrrhiza echinata, which have been used for years in Chinese traditional medicine. It displays antioxidant properties and anti-inflammatory activities. Echinatin exerts a protective effect against I/R-induced myocardial injury on hearts (as shown on the isolated rat hearts).

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.
2000 Jul-Aug
Cardioprotection provided by Echinatin against ischemia/reperfusion in isolated rat hearts.
2016 May 31
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
The hearts of the rats in the treatment groups were stabilized for 30 min and then treated with a Krebs-Henseleit buffer solution containing Echinatin (0.1, 0.5, and 2.5 ug/mL). Global ischemia and reperfusion were established for 45 min.
Name Type Language
ECHINATIN
Common Name English
2-PROPEN-1-ONE, 3-(4-HYDROXY-2-METHOXYPHENYL)-1-(4-HYDROXYPHENYL)-, (2E)-
Systematic Name English
RETROCHALCONE
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID301019928
Created by admin on Fri Dec 15 19:43:10 GMT 2023 , Edited by admin on Fri Dec 15 19:43:10 GMT 2023
PRIMARY
PUBCHEM
6442675
Created by admin on Fri Dec 15 19:43:10 GMT 2023 , Edited by admin on Fri Dec 15 19:43:10 GMT 2023
PRIMARY
CAS
34221-41-5
Created by admin on Fri Dec 15 19:43:10 GMT 2023 , Edited by admin on Fri Dec 15 19:43:10 GMT 2023
PRIMARY
FDA UNII
3816S4UA9R
Created by admin on Fri Dec 15 19:43:10 GMT 2023 , Edited by admin on Fri Dec 15 19:43:10 GMT 2023
PRIMARY