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Details

Stereochemistry ACHIRAL
Molecular Formula C16H14O4
Molecular Weight 270.28
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of ECHINATIN

SMILES

COC1=CC(O)=CC=C1\C=C\C(=O)C2=CC=C(O)C=C2

InChI

InChIKey=QJKMIJNRNRLQSS-WEVVVXLNSA-N
InChI=1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+

HIDE SMILES / InChI

Description

Echinatin is a component of Glycyrrhiza echinata, which have been used for years in Chinese traditional medicine. It displays antioxidant properties and anti-inflammatory activities. Echinatin exerts a protective effect against I/R-induced myocardial injury on hearts (as shown on the isolated rat hearts).

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
The hearts of the rats in the treatment groups were stabilized for 30 min and then treated with a Krebs-Henseleit buffer solution containing Echinatin (0.1, 0.5, and 2.5 ug/mL). Global ischemia and reperfusion were established for 45 min.