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Details

Stereochemistry ACHIRAL
Molecular Formula C16H14O4
Molecular Weight 270.28
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of ECHINATIN

SMILES

COC1=CC(O)=CC=C1\C=C\C(=O)C2=CC=C(O)C=C2

InChI

InChIKey=QJKMIJNRNRLQSS-WEVVVXLNSA-N
InChI=1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+

HIDE SMILES / InChI

Molecular Formula C16H14O4
Molecular Weight 270.28
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Echinatin is a component of Glycyrrhiza echinata, which have been used for years in Chinese traditional medicine. It displays antioxidant properties and anti-inflammatory activities. Echinatin exerts a protective effect against I/R-induced myocardial injury on hearts (as shown on the isolated rat hearts).

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Cardioprotection provided by Echinatin against ischemia/reperfusion in isolated rat hearts.
2016-05-31
Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.
2000-08-23
The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction.
1982-11
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
The hearts of the rats in the treatment groups were stabilized for 30 min and then treated with a Krebs-Henseleit buffer solution containing Echinatin (0.1, 0.5, and 2.5 ug/mL). Global ischemia and reperfusion were established for 45 min.
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:54:45 GMT 2025
Edited
by admin
on Mon Mar 31 19:54:45 GMT 2025
Record UNII
3816S4UA9R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RETROCHALCONE
Preferred Name English
ECHINATIN
Common Name English
2-PROPEN-1-ONE, 3-(4-HYDROXY-2-METHOXYPHENYL)-1-(4-HYDROXYPHENYL)-, (2E)-
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID301019928
Created by admin on Mon Mar 31 19:54:45 GMT 2025 , Edited by admin on Mon Mar 31 19:54:45 GMT 2025
PRIMARY
PUBCHEM
6442675
Created by admin on Mon Mar 31 19:54:45 GMT 2025 , Edited by admin on Mon Mar 31 19:54:45 GMT 2025
PRIMARY
CAS
34221-41-5
Created by admin on Mon Mar 31 19:54:45 GMT 2025 , Edited by admin on Mon Mar 31 19:54:45 GMT 2025
PRIMARY
FDA UNII
3816S4UA9R
Created by admin on Mon Mar 31 19:54:45 GMT 2025 , Edited by admin on Mon Mar 31 19:54:45 GMT 2025
PRIMARY