BMS-184476

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C49H55NO14S
Molecular Weight	914.024
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSCO[C@H]1C[C@H]2OC[C@@]2(OC(C)=O)[C@H]3[C@H](OC(=O)C4=CC=CC=C4)[C@]5(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]13C)C5(C)C

InChI

InChIKey=UBJAHGAUPNGZFF-XOVTVWCYSA-N

InChI=1S/C49H55NO14S/c1-27-33(62-45(57)38(53)37(30-17-11-8-12-18-30)50-43(55)31-19-13-9-14-20-31)24-49(58)42(63-44(56)32-21-15-10-16-22-32)40-47(6,41(54)39(61-28(2)51)36(27)46(49,4)5)34(60-26-65-7)23-35-48(40,25-59-35)64-29(3)52/h8-22,33-35,37-40,42,53,58H,23-26H2,1-7H3,(H,50,55)/t33-,34-,35+,37-,38+,39+,40-,42-,47+,48-,49+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15684226 | https://www.ncbi.nlm.nih.gov/pubmed/12901233 | https://adisinsight.springer.com/drugs/800012205

Bristol-Myers Squibb developed BMS-184476 for the potential treatment of solid tumors. BMS-184476 participated in phase II clinical trials for patients with non-small-cell lung cancer, breast, and ovarian cancers. However, that development has been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Phase II trial of the novel taxane BMS-184476 as second-line in non-small-cell lung cancer.	2005-04	15684226
BMS-184476 Bristol-Myers Squibb.	2003-06	12901233
Synthesis and antitumor activity of novel C-7 paclitaxel ethers: discovery of BMS-184476.	2001-12-20	11741476
Preclinical antitumor activity of two novel taxanes.	2001	11269747

Sample Use Guides

In Vivo Use Guide

Fifty-six previously treated advanced NSCLC patients received BMS-184476 at a dose of 60 mg/m(2) administered intravenously over 1 h every 21 days.

Route of Administration: Intravenous

Name

Type

Language

7-METHYLTHIOMETHYLPACLITAXEL

Preferred Name

English

BMS-184476

Common Name

English

PACLITAXEL-7-METHYLTHIOMETHYL ETHER

Common Name

English

7-O-((METHYLTHIO)METHYL)PACLITAXEL

Common Name

English

7-((METHYLTHIO)METHYL)PACLITAXEL

Common Name

English

7-methylthiomethylpaclitaxel [WHO-DD]

Common Name

English

PACLITAXEL, 7-((METHYLTHIO)METHYL)-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67437