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Details

Stereochemistry ACHIRAL
Molecular Formula C20H21F3N4O
Molecular Weight 390.4021
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLIBANSERIN

SMILES

FC(F)(F)C1=CC(=CC=C1)N2CCN(CCN3C(=O)NC4=C3C=CC=C4)CC2

InChI

InChIKey=PPRRDFIXUUSXRA-UHFFFAOYSA-N
InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://www.drugbank.ca/drugs/DB04908

Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder drug by Sprout Pharmaceuticals. Flibanserin's mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters. Flibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-HT (i.e., under stress), flibanserin may occupy 5-HT2A receptors in higher proportion than 5-HT(1A) receptors. It may also moderately antagonize D4 (dopamine) receptors and 5-HT2B and 5-HTB2C. Its action on neurotransmitter receptors may contribute to reduction in serotonin levels and increase in dopamine and norepinephrine levels, all of which may play part in reward processing. Flibanserin is sold under the trade name Addyi and indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty.

CNS Activity

Originator

Boehringer Ingelheim
131
Curator's Comment: developed by Sprout Pharmaceuticals https://www.drugs.com/history/addyi.html

Approval Year

2015
471
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
 7.31 null [pKi]
Agonist
2678
 4.0 nM [EC50]
Antagonist
2778
 115.0 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
ADDYI

Approved Use

ADDYI is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to: •A co-existing medical or psychiatric condition, •Problems within the relationship, or •The effects of a medication or other drug substance. Acquired HSDD refers to HSDD that develops in a patient who previously had no problems with sexual desire. Generalized HSDD refers to HSDD that occurs regardless of the type of stimulation, situation or partner. Limitations of Use •ADDYI is not indicated for the treatment of HSDD in postmenopausal women or in men. •ADDYI is not indicated to enhance sexual performance. ADDYI is indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to: •A co-existing medical or psychiatric condition, •Problems within the relationship, or •The effects of a medication or other drug substance. (1) Limitations of Use: •ADDYI is not indicated for the treatment of HSDD in postmenopausal women or in men. (1) •ADDYI is not indicated to enhance sexual performance. (1)

Launch Date

2015
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
419 ng/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022526s009lbl.pdf
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FLIBANSERIN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1543 ng × h/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022526s009lbl.pdf
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FLIBANSERIN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
11 h
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022526s009lbl.pdf
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FLIBANSERIN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
2%
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022526s009lbl.pdf
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FLIBANSERIN plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
600 mg single, oral
Dose: 600 mg
Route: oral
Route: single
Dose: 600 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/28814122
unknown, 2 yeras
n = 1
Health Status: unknown
Age Group: 2 yeras
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/28814122
Other AEs: Seizures...
Other AEs:
Seizures (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/28814122
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
unhealthy, 36 years (range: 18-56 years)
n = 1543
Health Status: unhealthy
Condition: hypoactive sexual desire disorder
Age Group: 36 years (range: 18-56 years)
Sex: F
Population Size: 1543
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
Disc. AE: Dizziness, Nausea...
AEs leading to
discontinuation/dose reduction:
Dizziness (1.7%)
Nausea (1.2%)
Insomnia (1.1%)
Somnolence (1.1%)
Anxiety (1%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
250 mg 1 times / day steady, oral
MTD
Dose: 250 mg, 1 times / day
Route: oral
Route: steady
Dose: 250 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/022526Orig1s000MedR.pdf
Page: p. 127
unhealthy
n = 6
Health Status: unhealthy
Sex: F
Population Size: 6
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/022526Orig1s000MedR.pdf
Page: p. 127
Other AEs: Dizziness, Nausea...
Other AEs:
Dizziness (83%)
Nausea (67%)
Somnolence (83%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/022526Orig1s000MedR.pdf
Page: p. 127
100 mg 1 times / day multiple, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: multiple
Dose: 100 mg, 1 times / day
Co-administed with::
alcohol(0.4 g/kg)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
unhealthy
n = 25
Health Status: unhealthy
Sex: M+F
Population Size: 25
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
Other AEs: Hypotension, Syncope...
Other AEs:
Hypotension (severe)
Syncope
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
20 mg single, intravenous
Dose: 20 mg
Route: intravenous
Route: single
Dose: 20 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/22219166
healthy
n = 12
Health Status: healthy
Sex: M
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/22219166
Sources:
https://pubmed.ncbi.nlm.nih.gov/22219166
AEs

AEs

AESignificanceDosePopulation
Seizures 1 patient
600 mg single, oral
Dose: 600 mg
Route: oral
Route: single
Dose: 600 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/28814122
unknown, 2 yeras
n = 1
Health Status: unknown
Age Group: 2 yeras
Sex: M
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/28814122
Anxiety 1%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
unhealthy, 36 years (range: 18-56 years)
n = 1543
Health Status: unhealthy
Condition: hypoactive sexual desire disorder
Age Group: 36 years (range: 18-56 years)
Sex: F
Population Size: 1543
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
Insomnia 1.1%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
unhealthy, 36 years (range: 18-56 years)
n = 1543
Health Status: unhealthy
Condition: hypoactive sexual desire disorder
Age Group: 36 years (range: 18-56 years)
Sex: F
Population Size: 1543
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
Somnolence 1.1%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
unhealthy, 36 years (range: 18-56 years)
n = 1543
Health Status: unhealthy
Condition: hypoactive sexual desire disorder
Age Group: 36 years (range: 18-56 years)
Sex: F
Population Size: 1543
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
Nausea 1.2%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
unhealthy, 36 years (range: 18-56 years)
n = 1543
Health Status: unhealthy
Condition: hypoactive sexual desire disorder
Age Group: 36 years (range: 18-56 years)
Sex: F
Population Size: 1543
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
Dizziness 1.7%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
unhealthy, 36 years (range: 18-56 years)
n = 1543
Health Status: unhealthy
Condition: hypoactive sexual desire disorder
Age Group: 36 years (range: 18-56 years)
Sex: F
Population Size: 1543
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
Nausea 67%
250 mg 1 times / day steady, oral
MTD
Dose: 250 mg, 1 times / day
Route: oral
Route: steady
Dose: 250 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/022526Orig1s000MedR.pdf
Page: p. 127
unhealthy
n = 6
Health Status: unhealthy
Sex: F
Population Size: 6
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/022526Orig1s000MedR.pdf
Page: p. 127
Dizziness 83%
250 mg 1 times / day steady, oral
MTD
Dose: 250 mg, 1 times / day
Route: oral
Route: steady
Dose: 250 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/022526Orig1s000MedR.pdf
Page: p. 127
unhealthy
n = 6
Health Status: unhealthy
Sex: F
Population Size: 6
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/022526Orig1s000MedR.pdf
Page: p. 127
Somnolence 83%
250 mg 1 times / day steady, oral
MTD
Dose: 250 mg, 1 times / day
Route: oral
Route: steady
Dose: 250 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/022526Orig1s000MedR.pdf
Page: p. 127
unhealthy
n = 6
Health Status: unhealthy
Sex: F
Population Size: 6
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/022526Orig1s000MedR.pdf
Page: p. 127
Syncope
100 mg 1 times / day multiple, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: multiple
Dose: 100 mg, 1 times / day
Co-administed with::
alcohol(0.4 g/kg)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
unhealthy
n = 25
Health Status: unhealthy
Sex: M+F
Population Size: 25
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
Hypotension severe
100 mg 1 times / day multiple, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: multiple
Dose: 100 mg, 1 times / day
Co-administed with::
alcohol(0.4 g/kg)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
unhealthy
n = 25
Health Status: unhealthy
Sex: M+F
Population Size: 25
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
substrate
1737

inhibitor
1587
substrate
1037
substrate
1217

inhibitor
1852
inhibitor
1612

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP2B6
810

P-gp
1461
CYP2C19
991

CYP1A2
1054

CYP2B6
664

CYP2C8
693

P-gp
1537

UGT
192

sulfotransferases
38
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP2D6
1891
 no
CYP2B6
1001
 yes [Ki 6.4 uM]
CYP3A4
1925
 yes [Ki 7.5 uM]
P-gp
1650
 yes
yes (co-administration study)
Comment: Digoxin exposure increased by 46%, 62% and 96% for Cmax, AUC0-t, and AUC0-inf, respectively, following multiple doses of flibanserin 100 mg co-administered with a single dose of digoxin 0.5 mg. A 96% increase in digoxin AUC suggests flibanserin is a P-gp inhibitor.
Page: 71.0
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
P-gp
1537
 likely
CYP3A4
1737
 major
yes (co-administration study)
Comment: In a pharmacokinetic drug interaction study of 50 mg flibanserin and 400 mg ketoconazole, a strong CYP3A4 inhibitor, syncope occurred in 1/24 (4%) healthy subjects treated with concomitant flibanserin and ketoconazole, 1/24 (4%) receiving flibanserin alone, and no subjects receiving ketoconazole alone. In this study, the concomitant use of flibanserin and ketoconazole increased flibanserin exposure 4.5-fold
Page: 44.0
CYP1A2
1054
 poor
CYP2B6
664
 poor
CYP2C8
693
 poor
CYP2C9
1037
 poor
no (co-administration study)
Comment: A study comparing flibanserin exposure in CYP2C9 poor metabolizers to CYP2C9 extensive metabolizers was conducted in lieu of a drug interaction study with ADDYI and a strong CYP2C9 inhibitor. In 8 women who were poor metabolizers of CYP2C9, Cmax and AUC0-inf of flibanserin 100 mg once daily decreased 23% and 18%, compared to exposures among 8 extensive metabolizers of CYP2C9.
Page: 44.0
CYP2D6
1217
 poor
no (co-administration study)
Comment: Paroxetine is a strong CYP2D6 inhibitor. In a study of 19 healthy male and female subjects, flibanserin exposure decreased by approximately 4% when flibanserin 50 mg twice daily was given with paroxetine compared to flibanserin alone. Paroxetine was dosed at 20 mg once daily for 3 days followed by 40 mg once daily for 7 days.
Page: 44.0
UGT
192
 yes
sulfotransferases
38
 yes
CYP2C19
991
 yes
yes (pharmacogenomic study)
Comment: In a pharmacogenomic study of 100 mg ADDYI in subjects who were poor or extensive CYP2C19 metabolizers, syncope occurred in 1/9 (11%) subjects who were CYP2C19 poor metabolizers (this subject had a 3.2 fold higher flibanserin exposure compared to CYP2C19 extensive metabolizers) compared to no such adverse reactions in subjects who were CYP2C19 extensive metabolizers
Page: 44.0
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
hERG
1647
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:90865
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:90865
ChemicalBook
CB91178756
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB91178756
MolPort
MolPort-006-170-023
https://www.molport.com/shop/molecule-link/MolPort-006-170-023
ZINC
ZINC000052716421
http://zinc15.docking.org/substances/ZINC000052716421
eMolecules
36367115
https://www.emolecules.com/cgi-bin/more?vid=36367115
PubMed

PubMed

TitleDatePubMed
Anti-anhedonic actions of the novel serotonergic agent flibanserin, a potential rapidly-acting antidepressant.
1997 Dec 11
Further characterisation of potential antidepressant action of flibanserin.
2001 Dec
Mechanism of action of flibanserin in the learned helplessness paradigm in rats.
2001 Dec 14
Ex vivo binding of flibanserin to serotonin 5-HT1A and 5-HT2A receptors.
2001 Feb
Lack of interaction between flibanserin and antidepressants in inducing serotonergic syndrome in rats.
2001 Mar
Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain.
2002 Jun
[Normality of the female libido (1)].
2010 Jun 30
Flibanserin: a potential treatment for Hypoactive Sexual Desire Disorder in premenopausal women.
2010 Sep
Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test.
2010 Sep
[When women complain about lacking libido. The problem with the desire].
2010 Sep 2
Mechanism of action of flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), in hypoactive sexual desire disorder.
2015 Feb
Patents

Patents

JP2003527422A
12
JP2007084576A
2
JP2007131631A
2
JP2007516949A
8
JP2008106028A
2
JP2013189481A
2
JP4789231B2
2

Sample Use Guides

In Vivo Use Guide
Recommended dosage is 100 mg taken once daily at bedtime, discontinue treatment after 8 weeks if no improvement
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Flibanserin behaves as a 5-HT1A agonist in the cortex and hippo-campus of human and rat brain
The concentration that reduces forskolin-induced cAMP formation by 50% in human hippocampus tissue was 4 nM.
Name Type Language
FLIBANSERIN
DASH   INN   MART.   MI   USAN   WHO-DD  
INN   USAN  
Official Name English
1,3-DIHYDRO-1-(2-(4-(3-(TRIFLUOROMETHYL)PHENYL)-1-PIPERAZINYL)ETHYL)-2H-BENZIMIDAZOL-2-ONE
Systematic Name English
BIMT 17 BS
Code English
1-(2-(4-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLYL)-1-PIPERAZINYL)ETHYL)-2-BENZIMIDAZOLINONE
Systematic Name English
BIMT-17-BS
Code English
BIMT 17
Code English
ADDYI
Brand Name English
flibanserin [INN]
Common Name English
FLIBANSERIN [MART.]
Common Name English
Flibanserin [WHO-DD]
Common Name English
FLIBANSERIN [USAN]
Common Name English
BIMT-17
Code English
FLIBANSERIN [ORANGE BOOK]
Common Name English
ECTRIS
Brand Name English
FLIBANSERIN [MI]
Common Name English
Classification Tree Code System Code
WHO-ATC G02CX02
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
NCI_THESAURUS C66885
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
Code System Code Type Description
CHEBI
90865
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
MERCK INDEX
m5402
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C80769
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
IUPHAR
8182
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
ChEMBL
CHEMBL231068
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
RXCUI
1665509
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY RxNorm
DRUG CENTRAL
5022
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
FDA UNII
37JK4STR6Z
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
USAN
KK-10
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
CAS
167933-07-5
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
DAILYMED
37JK4STR6Z
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
MESH
C098107
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
DRUG BANK
DB04908
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
NDF-RT
N0000185503
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY P-Glycoprotein Inhibitors [MoA]
SMS_ID
100000081014
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
PUBCHEM
6918248
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
INN
7512
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
WIKIPEDIA
FLIBANSERIN
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
EPA CompTox
DTXSID30168445
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
EVMPD
SUB07644MIG
Created by admin on Fri Dec 15 15:39:13 GMT 2023 , Edited by admin on Fri Dec 15 15:39:13 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of FLIBANSERIN
SALT/SOLVATE (PARENT)
Structure of FLIBANSERIN HYDROCHLORIDE
NIH
NCATS
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ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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