Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H29NO5 |
| Molecular Weight | 351.4373 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCOC(=O)CC1=CC=C(OCC(=O)N(CC)CC)C(OCC)=C1
InChI
InChIKey=QPUVKSKJCNGSGT-UHFFFAOYSA-N
InChI=1S/C19H29NO5/c1-5-11-24-19(22)13-15-9-10-16(17(12-15)23-8-4)25-14-18(21)20(6-2)7-3/h9-10,12H,5-8,11,13-14H2,1-4H3
AZD-3043, a short-acting intravenous anesthetic/sedative agent. This drug was initially invented by Theravance and then developed by AstraZeneca as a positive allosteric modulator of the γ-aminobutyric acid type A (GABA(A)) receptor containing a metabolically labile ester moiety. Phase I clinical trials for use this compound in anesthesia was completed in Sweden and the UK, but further development was discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Possible binding sites and interactions of propanidid and AZD3043 within the γ-aminobutyric acid type A receptor (GABAAR). | 2018-11 |
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| David (Propofol Wannabes) Versus Goliath (Propofol): AZD-3043 Goes Up Against the Giant! | 2015-10 |
|
| AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis. | 2012-06 |
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372AB76LQL
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DB12576
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10286834
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ACTIVE MOIETY
