FENPIVERINIUM BROMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H29N2O.Br
Molecular Weight	417.382
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

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Structure Search

SMILES

[Br-].C[N+]3(CCC(C(N)=O)(C1=CC=CC=C1)C2=CC=CC=C2)CCCCC3

InChI

InChIKey=PMAHPMMCPXYARU-UHFFFAOYSA-N

InChI=1S/C22H28N2O.BrH/c1-24(16-9-4-10-17-24)18-15-22(21(23)25,19-11-5-2-6-12-19)20-13-7-3-8-14-20;/h2-3,5-8,11-14H,4,9-10,15-18H2,1H3,(H-,23,25);1H

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6719639 | https://www.genome.jp/dbget-bin/www_bget?dr:D07070 | https://www.ncbi.nlm.nih.gov/pubmed/10638099

Fenpiverinium is a quaternary ammonium compound, it is an anticholinergic and antispasmodic agent. It is a constituent of Baralgin. The effects of the constituents of Baralgin (metamizole , fenpiverinium, and pitofenone ) on mechanical activity were studied in isolated human preparations of the upper urinary tract. Fenpiverinium blocked the increase in frequency of phasic-rhythmic contractions and the tonic tension development induced by acetylcholine. Fenpiverinium did influence neither spontaneous phasic activity nor activation by high potassium or norepinephrine. Fenpiverinium has exclusively anticholinergic properties. Fenpiverinium is a muscarinic acetylcholine receptor antagonist.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 160 Target ID: CHEMBL2094109 Sources: https://www.genome.jp/dbget-bin/www_bget?dr:D07070	Antagonist 2778

PubMed

Title	Date	PubMed
[Effect of Baralgin on isolated preparations of the upper urinary tract in man].	1984	6719639
Analgesics for pain relief after gynaecological surgery. A two-phase study.	1985 Mar 2	3885441
Open labelled evaluation of injection Manyana (a combination of diclofenac + pitofenone + fenpiverinium) in ureteric, biliary and intestinal spasm--a preliminary report.	1999 Sep	10638099

Sample Use Guides

In Vivo Use Guide

A two-phase, double-blind study was performed to assess the efficacy of various drugs in the relief of postoperative pain. Oral analgesia with two compounds (paracetamol 320 mg, caffeine 32 mg, codeine phosphate 8 mg and meprobamate 150 mg (Stopayne; Rio Ethicals) and dipyrone 500 mg, pitofenone hydrochloride 5 mg and fenpiverinium bromide 0,1 mg (Baralgan HS; Albert)) was found to produce satisfactory pain relief, and it is suggested that these oral compounds may be used from 12 hours postoperatively in uncomplicated cases.

Route of Administration: Oral

Name

Type

Language

FENPIVERINIUM BROMIDE

Official Name

English

FENPIVERINIUM BROMIDE [MI]

Common Name

English

1-(3-CARBAMOYL-3,3-DIPHENYLPROPYL)-1-METHYLPIPERIDINIUM BROMIDE

Systematic Name

English

FENPIPRAMIDE BROMOMETHYLATE

Common Name

English

Fenpiverinium bromide [WHO-DD]

Common Name

English

fenpiverinium bromide [INN]

Common Name

English

FENPIVERINIUM BROMIDE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29704