1-NAPHTHALENEACETIC ACID

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H10O2
Molecular Weight	186.2066
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

OC(=O)CC1=CC=CC2=CC=CC=C12

InChI

InChIKey=PRPINYUDVPFIRX-UHFFFAOYSA-N

InChI=1S/C12H10O2/c13-12(14)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-7H,8H2,(H,13,14)

HIDE SMILES / InChI

Description

1-Naphthyl acetate may be used in a rapid staining method for identification of macrophages. And it was used as a susbtrate for different type of esterases, e.g. butyrylcholinesterase, α-naphthyl acetate esterase for determination of their properties towards to insecticide resistance.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
horse butyrylcholinesteras 4	Substrate 661
α-naphthyl acetate esterase 4	Substrate 661

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2,578
Unknown 2,578
Gallbladder disease 13	Primary	Approved 8,429	Galle-Donau
Cholelithiasis 14	Primary	Approved 8,429	Galle-Donau

PubMed

Show entries

Title	Date	PubMed
Method for the Quantitative Determination of 1-Naphthaleneacetic Acid in Spiked Canned Pineapple Samples by Micelle-Stabilized Room Temperature Phosphorescence.	1998 Feb 16	10554277
Horn fly (Diptera: Muscidae) resistance to organophosphate insecticides.	2001 Apr 2	11240098
Acute promyelocytic leukemia, hypogranular variant, with uncharacteristic staining with chloroacetate esterase.	2001 Jun	11699210
Biochemical mechanisms of resistance in strains of Oryzaephilus surinamensis (Coleoptera: Silvanidae) resistant to malathion and chlorpyrifos-methyl.	2001 Jun	11425027
Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.	2001 Mar 8	11313866

Showing 1 to 5 of 26 entries

Previous1 2 3 4 5 6Next

Sample Use Guides

In Vivo Use Guide

1-2 dragees with liquid before each meal. The single dose can be increased to 3-4 dragees.

Route of Administration: Oral

In Vitro Use Guide

The enzymatic rate of the hydrolysis of 1-naphthylacetate as a function of substrate concentration (0.01-1.00 m m) was examined with human placental microsomes pooled from six placentae. K(m)value for this substrate was 118.2 uM and V(max)value was 105.3 nmol/mg/min.

Show entries

Name

Type

Language

1-NAPHTHALENEACETIC ACID

Official Name

English

2-(1-NAPHTHYL)ACETIC ACID

Systematic Name

English

.ALPHA.-NAPHTHALENEACETIC ACID

Systematic Name

English

1-NAPHTHYLACETIC ACID [JAN]

Common Name

English

PHYOMONE

Brand Name

English

Showing 1 to 5 of 46 entries

Previous1 2 3 4 5…10Next

Show entries

Classification Tree

Code System

Code

EPA PESTICIDE

EPA PESTICIDE CODE

56002

Designated

FDA ORPHAN DRUG

731020

Showing 1 to 2 of 2 entries

Previous1Next

Show entries

Code System

Code

Type

Description

CHEBI

32918

PRIMARY

WIKIPEDIA

1-NAPHTHALENEACETIC ACID

PRIMARY

NSC

15772

PRIMARY

FDA UNII

33T7G7757C

PRIMARY

ECHA (EC/EINECS)

201-705-8

PRIMARY

Showing 1 to 5 of 15 entries

Previous1 2 3Next

SUBSTANCE RECORD


					33T7G7757C

1-NAPHTHALENEACETIC ACID

SMILES

InChI

Approval Year

Targets

Conditions

PubMed

Patents

Sample Use Guides