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Details

Stereochemistry ACHIRAL
Molecular Formula C11H8I3N2O4.Na
Molecular Weight 629.8959
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOTHALAMATE SODIUM I-125

SMILES

[Na+].CNC(=O)C1=C([125I])C(NC(C)=O)=C([125I])C(C([O-])=O)=C1[125I]

InChI

InChIKey=WCIMWHNSWLLELS-SQHZOQHUSA-M
InChI=1S/C11H9I3N2O4.Na/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20;/h1-2H3,(H,15,18)(H,16,17)(H,19,20);/q;+1/p-1/i12-2,13-2,14-2;

HIDE SMILES / InChI
Iothalamic acid is a Radiographic Contrast Agent. The mechanism of action of iothalamic acid is as a X-Ray Contrast Activity. GLOFIL-125 (Sodium Iothalamate I-125 Injection) is a sterile, nonpyrogenic aqueous injection containing approximately 1 mg sodium iothalamate per mL, and 0.9 percent benzyl alcohol as a preservative. The radioactive concentration of the material is 250-300 µCi/mL as of the calibration date. Sodium bicarbonate and hydrochloric acid are present for pH adjustment. GLOFIL-125 (Sodium Iothalamate I-125 Injection) is indicated for evaluation of glomerular filtration in the diagnosis or monitoring of patients with renal disease. The renal clearance of sodium iothalamate in man closely approximates that of inulin. The compound is cleared by glomerular filtration without tubular secretion or reabsorption. Following infusion administration of I-125 iothalamate, the effective half-life is about 0.07 days.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
GLOFIL-125

Approved Use

Unknown

Sample Use Guides

In the average patient (70 kg) is as follows: Continuous intravenous infusion: 20 to 100 μCi (0.74-3.7 megabecquerels) Single intravenous injection: 10 to 30 µCi (0.37-1.11 megabecquerels)
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Name Type Language
IOTHALAMATE SODIUM I-125
ORANGE BOOK  
Common Name English
IOTHALAMATE SODIUM, I-125
Preferred Name English
Monosodium 5-acetamido-triiodo-N-methylisophthalamate, labeled with iodine-125
Common Name English
IOTHALAMATE SODIUM I-125 [ORANGE BOOK]
Common Name English
sodium iotalamate (¹²⁵I) [INN]
Common Name English
IOTHALAMATE SODIUM I125
Common Name English
SODIUM IOTHALAMATE (125I)
Common Name English
IODINE (125I) SODIUM IOTALAMATE
Common Name English
SODIUM IOTALAMATE (125 I)
Common Name English
BENZOIC ACID, 3-(ACETYLAMINO)TRI(IODO-125I)-5-((METHYLAMINO)CARBONYL)-, SODIUM SALT (1:1)
Common Name English
IOTHALAMATE SODIUM I 125
USAN  
USAN  
Official Name English
SODIUM IOTALAMATE (125I)
INN  
INN  
Official Name English
BENZOIC ACID, 3-(ACETYLAMINO)-2,4,6-TRIIODO-5-((METHYLAMINO)CARBONYL)-, LABELED WITH IODINE-125, SODIUM SALT (1:1)
Common Name English
IOTHALAMATE SODIUM I 125 [USAN]
Common Name English
Classification Tree Code System Code
WHO-VATC QV09CX03
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
WHO-ATC V09CX03
Created by admin on Fri Dec 15 14:58:03 GMT 2023 , Edited by admin on Fri Dec 15 14:58:03 GMT 2023
NDF-RT N0000177914
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
NCI_THESAURUS C2124
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
Code System Code Type Description
FDA UNII
31J5U3Q9ZN
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
PRIMARY
INN
2344
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201300
Created by admin on Fri Dec 15 14:58:03 GMT 2023 , Edited by admin on Fri Dec 15 14:58:03 GMT 2023
PRIMARY
LACTMED
Iothalamate Sodium I 125
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
PRIMARY
CAS
23549-00-0
Created by admin on Fri Dec 15 14:58:03 GMT 2023 , Edited by admin on Fri Dec 15 14:58:03 GMT 2023
ALTERNATIVE
EPA CompTox
DTXSID9057896
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
PRIMARY
RXCUI
91537
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
PRIMARY RxNorm
CAS
17692-74-9
Created by admin on Fri Dec 15 14:58:03 GMT 2023 , Edited by admin on Fri Dec 15 14:58:03 GMT 2023
PRIMARY
DAILYMED
31J5U3Q9ZN
Created by admin on Fri Dec 15 14:58:03 GMT 2023 , Edited by admin on Fri Dec 15 14:58:03 GMT 2023
PRIMARY
PUBCHEM
23724931
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
PRIMARY
EVMPD
SUB10565MIG
Created by admin on Fri Dec 15 14:58:03 GMT 2023 , Edited by admin on Fri Dec 15 14:58:03 GMT 2023
PRIMARY
SMS_ID
100000092235
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
PRIMARY
DRUG BANK
DBSALT001236
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
PRIMARY
NCI_THESAURUS
C47570
Created by admin on Fri Dec 15 14:58:04 GMT 2023 , Edited by admin on Fri Dec 15 14:58:04 GMT 2023
PRIMARY