IOTHALAMATE SODIUM I-125

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H8I3N2O4.Na
Molecular Weight	629.8959
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].CNC(=O)C1=C([125I])C(C([O-])=O)=C([125I])C(NC(C)=O)=C1[125I]

InChI

InChIKey=WCIMWHNSWLLELS-SQHZOQHUSA-M

InChI=1S/C11H9I3N2O4.Na/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20;/h1-2H3,(H,15,18)(H,16,17)(H,19,20);/q;+1/p-1/i12-2,13-2,14-2;

HIDE SMILES / InChI

Molecular Formula	C11H8I3N2O4
Molecular Weight	606.9061
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2c07ce91-cc83-45e3-bd2b-f923a9c8286c

Iothalamic acid is a Radiographic Contrast Agent. The mechanism of action of iothalamic acid is as a X-Ray Contrast Activity. GLOFIL-125 (Sodium Iothalamate I-125 Injection) is a sterile, nonpyrogenic aqueous injection containing approximately 1 mg sodium iothalamate per mL, and 0.9 percent benzyl alcohol as a preservative. The radioactive concentration of the material is 250-300 µCi/mL as of the calibration date. Sodium bicarbonate and hydrochloric acid are present for pH adjustment. GLOFIL-125 (Sodium Iothalamate I-125 Injection) is indicated for evaluation of glomerular filtration in the diagnosis or monitoring of patients with renal disease. The renal clearance of sodium iothalamate in man closely approximates that of inulin. The compound is cleared by glomerular filtration without tubular secretion or reabsorption. Following infusion administration of I-125 iothalamate, the effective half-life is about 0.07 days.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Glomerular filtration 2 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7f250086-2837-484b-9674-e09856b34cb0	Diagnostic		Approved 8583	GLOFIL-125 Approved Use Unknown

Sample Use Guides

In Vivo Use Guide

In the average patient (70 kg) is as follows: Continuous intravenous infusion: 20 to 100 μCi (0.74-3.7 megabecquerels) Single intravenous injection: 10 to 30 µCi (0.37-1.11 megabecquerels)

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:33:15 GMT 2025` Edited by `admin` on `Mon Mar 31 17:33:15 GMT 2025`
Record UNII	31J5U3Q9ZN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IOTHALAMATE SODIUM I-125

Common Name

English

SODIUM IOTALAMATE (125I)

Preferred Name

English

Monosodium 5-acetamido-triiodo-N-methylisophthalamate, labeled with iodine-125

Common Name

English

IOTHALAMATE SODIUM I-125 [ORANGE BOOK]

Common Name

English

sodium iotalamate (¹²?I) [INN]

Common Name

English

IOTHALAMATE SODIUM I125

Common Name

English

SODIUM IOTHALAMATE (125I)

Common Name

English

IODINE (125I) SODIUM IOTALAMATE

Common Name

English

SODIUM IOTALAMATE (125 I)

Common Name

English

BENZOIC ACID, 3-(ACETYLAMINO)TRI(IODO-125I)-5-((METHYLAMINO)CARBONYL)-, SODIUM SALT (1:1)

Common Name

English

IOTHALAMATE SODIUM, I-125

Common Name

English

IOTHALAMATE SODIUM I 125

Official Name

English

BENZOIC ACID, 3-(ACETYLAMINO)-2,4,6-TRIIODO-5-((METHYLAMINO)CARBONYL)-, LABELED WITH IODINE-125, SODIUM SALT (1:1)

Common Name

English

IOTHALAMATE SODIUM I 125 [USAN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QV09CX03