U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C40H80NO8P
Molecular Weight 734.0389
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COLFOSCERIL PALMITATE

SMILES

CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC

InChI

InChIKey=KILNVBDSWZSGLL-KXQOOQHDSA-N
InChI=1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1

HIDE SMILES / InChI

Description

Colfosceril palmitate (dipalmitoylphosphatidylcholine) is a synthetic pulmonary surfactant, which is used in infants with respiratory distress syndrome it was approved in 1990, but nowadays it is under the state of canceled post-marketing. Colfosceril palmitate is reducing the tension and stabilizing the alveoli from collapsing.

Originator

Approval Year

1990
108
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
EXOSURF NEONATAL

Approved Use

Exosurf® is only for the treatment or prevention of respiratory distress syndrome in newborn infants

Launch Date

2000
Sourcing

Sourcing

Vendor/AggregatorIDURL
3B Scientific (Wuhan) Corp
3B2-5565
http://www.3bsc.com/index/pro_info.php?id=85367
AA Blocks
AA003DBZ
http://www.aablocks.com/goods/Goods/detail?id=AA003DBZ
AEchem Scientific Corp., USA
AE052774
http://www.aechemsc.com/info_products/AE052774.php
AHH Chemical co.,ltd
MT-53101
http://www.ahhchemical.com/product/MT-53101.html
AK Scientific, Inc. (AKSCI)
K017
http://www.aksci.com/item_detail.php?cat=K017
Aaron Chemicals
AR003E3R
http://www.aaronchem.com/63-89-8
Acros Organics
AC240570025
https://www.fishersci.com/shop/products/l-alpha-dipalmitoyl-phosphatidylcholine-98-acros-organics-2/AC240570025
Ambeed
A542590
https://www.ambeed.com/products/63-89-8.html
Angene
AGN-PC-0TADZG
http://www.angenechemical.com/productshow/AGN-PC-0TADZG.html
Aurora Fine Chemicals LLC
A17.876.272
http://online.aurorafinechemicals.com/info?ID=A17.876.272
Aurora Fine Chemicals LLC
K14.820.059
http://online.aurorafinechemicals.com/info?ID=K14.820.059
BLD Pharm
BD53403
http://www.bldpharm.com/products/63-89-8.html
CSNpharm
CSN17079
https://www.csnpharm.com/products/colfosceril-palmitate.html
Chem Scene
CS-0031214
http://www.chemscene.com/63-89-8.html
Chemenu
CM129196
http://www.chemenu.com/products/CM129196
Chemspace
CSSB00000053731
https://chem-space.com/CSSB00000053731
DC Chemicals
DC32182
http://www.dcchemicals.com//product_show-Colfosceril_Palmitate.html
Glentham Life Sciences
GL3400
http://www.glentham.com/products/product/GL3400/
MedChem Express
HY-109506
https://www.medchemexpress.com/DPPC.html
Sigma-Aldrich
850355P_AVANTI
https://www.sigmaaldrich.com/catalog/product/avanti/850355p?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
P0763_SIGMA
https://www.sigmaaldrich.com/catalog/product/sigma/p0763?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
P4329_SIGMA
https://www.sigmaaldrich.com/catalog/product/sigma/p4329?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule
S532689
http://www.smolecule.com/products/s532689
TCI (Tokyo Chemical Industry)
D3925
http://www.tcichemicals.com/eshop/en/us/commodity/D3925/index.html
THE BioTek
bt-272861
https://www.thebiotek.com/product/inhibitors/bt-272861
VladaChem
VL280798-25MG
https://www.vladachem.com/product.php?products=63-89-8
abcr GmbH
AB331720
http://www.abcr.com/shop/en/AB331720
eNovation Chemicals
D955234
https://www.enovationchem.com/ProductDetails.asp?ProductID=D955234
PubMed

PubMed

TitleDatePubMed
Colfosceril palmitate. A review of the therapeutic efficacy and clinical tolerability of a synthetic surfactant preparation (Exosurf Neonatal) in neonatal respiratory distress syndrome.
1991 Nov
Unilateral pulmonary interstitial emphysema and treatment with colfosceril palmitate.
1993 Jun 19
Colfosceril palmitate. A pharmacoeconomic evaluation of a synthetic surfactant preparation (Exosurf Neonatal) in infants with respiratory distress syndrome.
1994 Dec
A multicenter, randomized, masked, comparison trial of lucinactant, colfosceril palmitate, and beractant for the prevention of respiratory distress syndrome among very preterm infants.
2005 Apr
Patents

Patents

EP1976535A2
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Other
In Vitro Use Guide
Unknown
Name Type Language
COLFOSCERIL PALMITATE
DASH   INN   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
DPPC, L-
Common Name English
3,5,9-TRIOXA-4-PHOSPHAPENTACOSAN-1-AMINIUM, 4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-7-((1-OXOHEXADECYL)OXY)-, HYDROXIDE, INNER SALT, 4-OXIDE, (R)-
Common Name English
colfosceril palmitate [INN]
Common Name English
1.2 DIPALMITOYL-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE
Common Name English
COLFOSCERIL PALMITATE [USAN]
Common Name English
DIPALMITOYL LECITHIN, L-
Common Name English
COLFOSCERIL [VANDF]
Common Name English
1,2-DIHEXADECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Common Name English
129Y83
Code English
COLFOSCERIL PALMITATE COMPONENT OF EXOSURF NEONATAL
Common Name English
DIPALMITOYL GLYCEROPHOSPHOCHOLINE [INCI]
Common Name English
OP0201 COMPONENT COLFOSCERIL PALMITATE
Common Name English
CHOLINE HYDROXIDE, DIHYDROGEN PHOSPHATE, INNER SALT, ESTER WITH L-1,2-DIPALMITIN
Common Name English
COLFOSCERIL PALMITATE [ORANGE BOOK]
Common Name English
Colfosceril palmitate [WHO-DD]
Common Name English
DPPC, R-
Common Name English
DIPALMITOYLPHOSPHATIDYLCHOLINE
Common Name English
COLFOSCERIL PALMITATE [VANDF]
Common Name English
EXOSURF NEONATAL COMPONENT COLFOSCERIL PALMITATE
Common Name English
OP-0201 COMPONENT COLFOSCERIL PALMITATE
Common Name English
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Common Name English
DIPALMITOYL GLYCEROPHOSPHOCHOLINE
INCI  
INCI  
Official Name English
1.2 DIPALMITOYL-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE (DPPC)
Common Name English
LUCINACTANT COMPONENT DPPC
Common Name English
COLFOSCERIL PALMITATE [MI]
Common Name English
129-Y-83
Code English
SURFAXIN COMPONENT DPPC
Brand Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 68492
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
WHO-VATC QR07AA01
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
LOINC 2215-2
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
FDA ORPHAN DRUG 14886
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
NCI_THESAURUS C78273
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
FDA ORPHAN DRUG 29688
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
WHO-ATC R07AA01
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
Code System Code Type Description
RXCUI
69782
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
DRUG CENTRAL
730
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
NCI_THESAURUS
C47462
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
EVMPD
SUB22681
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-567-6
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
CAS
63-89-8
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
SMS_ID
100000084265
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
FDA UNII
319X2NFW0A
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
MERCK INDEX
m3731
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY Merck Index
DRUG BANK
DB09114
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
MESH
C081581
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
ChEMBL
CHEMBL1200737
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
PUBCHEM
452110
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
INN
6728
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
RXCUI
107784
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
ALTERNATIVE
DAILYMED
319X2NFW0A
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
CHEBI
72999
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
EVMPD
SUB06799MIG
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
USAN
AA-82
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
CHEBI
40265
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
EPA CompTox
DTXSID5046720
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
WIKIPEDIA
COLFOSCERIL PALMITATE
Created by admin on Fri Dec 15 15:25:29 GMT 2023 , Edited by admin on Fri Dec 15 15:25:29 GMT 2023
PRIMARY
NIH
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