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Details

Stereochemistry ACHIRAL
Molecular Formula C21H21N
Molecular Weight 287.3981
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYPROHEPTADINE

SMILES

CN1CCC(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C24

InChI

InChIKey=JJCFRYNCJDLXIK-UHFFFAOYSA-N
InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3

HIDE SMILES / InChI

Description

Cyproheptadine hydrochloride anhydrous is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It is indicted for the treatment of perennial and seasonal allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis due to inhalant allergens and foods; mild, uncomplicated allergic skin manifestations of urticaria and angioedema. As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled. MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents. Common adverse effects are: sedation, sleepiness (often transient), dizziness, disturbed coordination, restlessness, excitation.

CNS Activity

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
CYPROHEPTADINE HYDROCHLORIDE
Primary
CYPROHEPTADINE HYDROCHLORIDE
Primary
CYPROHEPTADINE HYDROCHLORIDE
Primary
PERIACTIN
Primary
CYPROHEPTADINE HYDROCHLORIDE
Primary
PERIACTIN
Primary
PERIACTIN
Primary
CYPROHEPTADINE HYDROCHLORIDE
Primary
CYPROHEPTADINE HYDROCHLORIDE
Primary
CYPROHEPTADINE HYDROCHLORIDE
PubMed

PubMed

TitleDatePubMed
Survey on treatments for primary headaches in 13 specialized juvenile Headache Centers: The first multicenter Italian study.
2017 May
Patents

Sample Use Guides

In Vivo Use Guide
4 mg PO q8hr initially; maintenance: 4-20 mg/day, up to 32 mg/day divided q8hr in some patients; not to exceed 0.5 mg/kg/day
Route of Administration: Oral
In Vitro Use Guide
Cytotoxic effect of Cyproheptadine (Glutodine) on urothelial cancer cells was determined in SV-HUC1, TSGH 8301, BFTC 905, BFTC 909, J82, 5637 cell lined. Cells were treated with 25-- 150 mkM of Cyproheptadine for 24 h. Apoptosis analysis was performed using the Annexin V-FITC Apoptosis Detection Kit. Treatment with high dose Cyproheptadine (≥100 mkM) for 24 h induced significant cytotoxicity toward all bladder cancer cells, 50 mkM of Cyproheptadine only induced cytotoxicity in cancer cell lines but not in the immortalized normal urothelial SV-HUC1 cells
Name Type Language
CYPROHEPTADINE
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
CYPROHEPTADINE [MI]
Common Name English
CIPROVIT
Brand Name English
CYPROHEPTADINE [WHO-DD]
Common Name English
CYPROHEPTADINE [VANDF]
Common Name English
CYPROHEPTADINE [HSDB]
Common Name English
PIPERIDINE, 4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-METHYL-
Systematic Name English
CYPROHEPTADINE [INN]
Common Name English
4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-METHYLPIPERIDINE
Systematic Name English
Classification Tree Code System Code
WHO-ATC R06AX02
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
LIVERTOX 251
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
NCI_THESAURUS C29578
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
WHO-VATC QR06AX02
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
Code System Code Type Description
RXCUI
3013
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY RxNorm
LactMed
129-03-3
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
WIKIPEDIA
CYPROHEPTADINE
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
INN
872
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
EVMPD
SUB06875MIG
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
CAS
129-03-3
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
DRUG BANK
DB00434
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
IUPHAR
277
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
MERCK INDEX
M4040
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY Merck Index
EPA CompTox
129-03-3
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
PUBCHEM
2913
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
ChEMBL
CHEMBL516
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
NCI_THESAURUS
C61695
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
HSDB
129-03-3
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
MESH
D003533
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY
ECHA (EC/EINECS)
204-928-9
Created by admin on Tue Oct 22 00:43:39 UTC 2019 , Edited by admin on Tue Oct 22 00:43:39 UTC 2019
PRIMARY