Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H21NO3.H3O4P |
| Molecular Weight | 397.3594 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OP(O)(O)=O.[H][C@@]12OC3=C4C(C[C@H]5N(C)CC[C@@]14[C@@]5([H])C=C[C@@H]2O)=CC=C3OC
InChI
InChIKey=WUXLCJZUUHIXFY-FFHNEAJVSA-N
InChI=1S/C18H21NO3.H3O4P/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4/h3-6,11-13,17,20H,7-9H2,1-2H3;(H3,1,2,3,4)/t11-,12+,13-,17-,18-;/m0./s1
Codeine is an opiate used to manage mild to moderate pain severe enough to require an opioid. Codeine is a selective agonist for the mu opioid receptor and has an affinity to delta and kappa-opioid receptors. In some countries, this drug is regulated under various narcotic control laws, because its chronic use can cause physical dependence. In others, it is available without a medical prescription in combination with paracetamol.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL233 |
6.1 µM [EC50] | ||
Target ID: P41145 Gene ID: 4986.0 Gene Symbol: OPRK1 Target Organism: Homo sapiens (Human) |
|||
Target ID: P41143 Gene ID: 4985.0 Gene Symbol: OPRD1 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | CAPITAL AND CODEINE Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Determination of opiates in serum, saliva and hair addicted persons. | 2001 |
|
| Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis. | 2001 |
|
| Pharmacological control of cough. | 2001 Apr |
|
| The use of compound 48/80 and codeine phosphate as positive controls for intradermal skin testing in dogs. | 2001 Apr |
|
| Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures. | 2001 Apr |
|
| Angle closure risk from proprietary medicines. | 2001 Apr |
|
| [Adverse cutaneous side-effect of codeine administration]. | 2001 Apr 15 |
|
| Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women. | 2001 Aug |
|
| Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC. | 2001 Aug |
|
| Prescribing limitations. | 2001 Aug 11 |
|
| Precipitated withdrawal following codeine administration is dependent on CYP genotype. | 2001 Aug 17 |
|
| [Paracetamol-codeine induced hepatic colic]. | 2001 Aug-Sep |
|
| Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth. | 2001 Feb |
|
| Effect of prophylactic amoxicillin on endodontic flare-up in asymptomatic, necrotic teeth. | 2001 Jan |
|
| Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis. | 2001 Jul |
|
| Head-column field-amplified sample stacking in presence of siphoning. Application to capillary electrophoresis-electrospray ionization mass spectrometry of opioids in urine. | 2001 Jul 27 |
|
| Use of beta-cyclodextrin in the capillary zone electrophoretic separation of the components of clandestine heroin preparations. | 2001 Jul 27 |
|
| Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. | 2001 Jul 7 |
|
| [Chronic pain in geriatrics]. | 2001 Jun |
|
| Myth: codeine is a powerful and effective analgesic. | 2001 Jun |
|
| Oral ibuprofen versus paracetamol plus codeine for analgesia after ambulatory surgery. | 2001 Jun |
|
| Ulcerated hemangiomas: clinical characteristics and response to therapy. | 2001 Jun |
|
| Analysis of cocaine, benzoylecgonine, codeine, and morphine in hair by supercritical fluid extraction with carbon dioxide modified with methanol. | 2001 Jun 1 |
|
| Time of drug elimination in chronic drug abusers. Case study of 52 patients in a "low-step" detoxification ward. | 2001 Jun 15 |
|
| Expression and activity of cell-wall-degrading enzymes in the latex of opium poppy, Papaver somniferum L. | 2001 Mar |
|
| Myocardial Infarction associated with methadone and/or dihydrocodeine. | 2001 Mar |
|
| Dextromethorphan is an effective cough suppressant. | 2001 May |
|
| Dihydrocodeine--drug of use or misuse? | 2001 May |
|
| Effect of an enteric-release formulation of naloxone on intestinal transit in volunteers taking codeine. | 2001 May |
|
| The analgesic effect of codeine as compared to imipramine in different human experimental pain models. | 2001 May |
|
| [Analgesics-induced chronic renal failure in patients on dialysis therapy in Hungary]. | 2001 May 13 |
|
| Capillary electrophoresis-electrospray ionization ion trap mass spectrometry for analysis and confirmation testing of morphine and related compounds in urine. | 2001 May 4 |
|
| Application of liquid chromatography to the simultaneous determination of acetylsalicylic acid, caffeine, codeine, paracetamol, pyridoxine, and thiamine in pharmaceutical preparations. | 2001 May-Jun |
|
| Regional block and mexiletine: the effect on pain after cancer breast surgery. | 2001 May-Jun |
|
| Scalp nerve blocks decrease the severity of pain after craniotomy. | 2001 Nov |
|
| Nutritional effects of surgical and medical treatment for short bowel syndrome. | 2001 Nov-Dec |
|
| Novel dynamic polymer coating for capillary electrophoresis in nonaqueous methanolic background electrolytes. | 2001 Oct |
|
| Seizures with intravenous codeine phosphate. | 2001 Oct |
|
| Analysis of morphine and codeine in samples adulterated with Stealth. | 2001 Oct |
|
| Detection of opiate use in a methadone maintenance treatment population with the CEDIA 6-acetylmorphine and CEDIA DAU opiate assays. | 2001 Oct |
|
| Drug contamination of US paper currency. | 2001 Oct 1 |
|
| Endogenous morphine and codeine. Possible role as endogenous anticonvulsants. | 2001 Oct 12 |
|
| Spontaneous reports on drug-induced pancreatitis in Denmark from 1968 to 1999. | 2001 Sep |
|
| Community pharmacists' experience of over-the-counter medicine misuse in Scotland. | 2001 Sep |
|
| Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study. | 2001 Sep |
|
| Rofecoxib versus codeine/acetaminophen in postoperative dental pain: a double-blind, randomized, placebo- and active comparator-controlled clinical trial. | 2001 Sep |
|
| Concentration ratios of codeine-to-morphine in plasma after a single oral dose (100 mg) of codeine phosphate. | 2001 Sep |
|
| Pain control in medical abortion. | 2001 Sep |
|
| Engineering novel biocatalytic routes for production of semisynthetic opiate drugs. | 2001 Sep |
|
| Experience with urine drug testing by the Correctional Service of Canada. | 2001 Sep 15 |
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID0024844
Created by
admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
|
PRIMARY | |||
|
52-28-8
Created by
admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
|
PRIMARY | |||
|
2X585M1M3T
Created by
admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
|
PRIMARY | |||
|
5359227
Created by
admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
|
PRIMARY | |||
|
m3718
Created by
admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
|
PRIMARY | Merck Index | ||
|
1652891
Created by
admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
|
PRIMARY | RxNorm | ||
|
100000079791
Created by
admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
|
PRIMARY | |||
|
2X585M1M3T
Created by
admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
|
PRIMARY | |||
|
200-137-8
Created by
admin on Fri Dec 15 17:39:30 GMT 2023 , Edited by admin on Fri Dec 15 17:39:30 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
