INDENOLOL HYDROCHLORIDE

Description
Sources: http://jpdb.nihs.go.jp/jp14e/14data/Part-I/Indenolol_Hydrochloride.pdf
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/6337761

Indenolol hydrochloride is a mixture of 1-(7-in-denyloxy)-3-isopropylamino-2-propanol monohydrochloride and 1-(4-indenyloxy)-3-isopr opylamino-2-propanol monohydrochloride. Indenolol is a non-cardioselective beta blocker used to treat hypertension.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor beta 87 Target ID: CHEMBL2094118 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01958 \| https://www.jstage.jst.go.jp/article/cpb1958/24/3/24_3_552/_article	Blocker 537

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4031109	Primary		Approved 8429	PULSAN Approved Use Unknown

PubMed

Title	Date	PubMed
Indenolol: a new antihypertensive agent: efficacy, toxicity, and hemodynamic effects in a crossover double-blind study with metoprolol.	1985 Jul-Aug	4031109

Patents

Sample Use Guides

In Vivo Use Guide

In clinical trials against hypertension, indenolol was administered daily at doses of 60 mg or 120 mg.

Route of Administration: Oral

In Vitro Use Guide

Indenolol hydrochloride exhibited beta-blocking activity in isolated atria with pA2 of 8.38.

Name

Type

Language

INDENOLOL HYDROCHLORIDE

Common Name

English

INDENOLOL HYDROCHLORIDE [JAN]

Common Name

English

INDENOLOL HYDROCHLORIDE [MART.]

Common Name

English

INDENOLOL HYDROCHLORIDE [MI]

Common Name

English

INDENOLOL HCL

Common Name

English

Indenolol hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

CAS

81789-85-7