ISOXEPAC

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12O4
Molecular Weight	268.2641
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CC1=CC2=C(OCC3=C(C=CC=C3)C2=O)C=C1

InChI

InChIKey=QFGMXJOBTNZHEL-UHFFFAOYSA-N

InChI=1S/C16H12O4/c17-15(18)8-10-5-6-14-13(7-10)16(19)12-4-2-1-3-11(12)9-20-14/h1-7H,8-9H2,(H,17,18)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7013009 | https://www.ncbi.nlm.nih.gov/pubmed/7040500

Isoxepac (also known) as HP-549 is a non-steroidal anti-inflammatory drug with analgesic activity. Isoxepac was studied in the clinical trial for the treatment of postoperative pain after knee surgery for meniscectomy. It was shown, that 200 mg of isoxepac would appear to be the minimal effective dose. In case of rheumatoid arthritis, isoxepac showed significantly fewer adverse effects.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatoid arthritis 316 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7013009	Palliative		Not Provided 504	Unknown Approved Use Unknown
Postmeniscectomy pain 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7040500	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Quantitative analysis of 6,11-dihydro-11-oxo-dibenz[b,e] oxepin-2-acetic acid (isoxepac) in plasma and urine by gas--liquid chromatography.	1978 May 1	659525
Isoxepac in rheumatoid arthritis: a double-blind comparison with aspirin.	1981 Feb 1	7013009
Local buccal mucosal effects of aspirin, indomethacin and isoxepac: their relationship to gastrointestinal damage.	1981 May	7272169
Analgesic effect of isoxepac on postmeniscectomy pain: a controlled trial.	1982 Feb-Mar	7040500

Patents

Sample Use Guides

In Vivo Use Guide

rheumatoid arthritis: 200 mg three times daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

ISOXEPAC

Official Name

English

HP 549

Code

English

isoxepac [INN]

Common Name

English

ISOXEPAC [USAN]

Common Name

English

OLOPATADINE RELATED COMPOUND C [USP IMPURITY]

Common Name

English

P 720549

Code

English

6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid

Systematic Name

English

ARTIL

Brand Name

English

HP-549

Code

English

OLOPATADINE RELATED COMPOUND C

Common Name

English

NSC-300907

Code

English

OLOPATADINE RELATED COMPOUND C [USP-RS]

Common Name

English

ISOXEPAC [MI]

Common Name

English

DIBENZ(B,E)OXEPIN-2-ACETIC ACID, 6,11-DIHYDRO-11-OXO-

Common Name

English

P-720549

Code

English

Code System Code Type Description

RS_ITEM_NUM

1478436