U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H12O4
Molecular Weight 268.2641
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISOXEPAC

SMILES

OC(=O)CC1=CC2=C(OCC3=C(C=CC=C3)C2=O)C=C1

InChI

InChIKey=QFGMXJOBTNZHEL-UHFFFAOYSA-N
InChI=1S/C16H12O4/c17-15(18)8-10-5-6-14-13(7-10)16(19)12-4-2-1-3-11(12)9-20-14/h1-7H,8-9H2,(H,17,18)

HIDE SMILES / InChI
Isoxepac (also known) as HP-549 is a non-steroidal anti-inflammatory drug with analgesic activity. Isoxepac was studied in the clinical trial for the treatment of postoperative pain after knee surgery for meniscectomy. It was shown, that 200 mg of isoxepac would appear to be the minimal effective dose. In case of rheumatoid arthritis, isoxepac showed significantly fewer adverse effects.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Quantitative analysis of 6,11-dihydro-11-oxo-dibenz[b,e] oxepin-2-acetic acid (isoxepac) in plasma and urine by gas--liquid chromatography.
1978 May 1
Isoxepac in rheumatoid arthritis: a double-blind comparison with aspirin.
1981 Feb 1
Local buccal mucosal effects of aspirin, indomethacin and isoxepac: their relationship to gastrointestinal damage.
1981 May
Analgesic effect of isoxepac on postmeniscectomy pain: a controlled trial.
1982 Feb-Mar
Patents

Sample Use Guides

rheumatoid arthritis: 200 mg three times daily
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
ISOXEPAC
INN   MI   USAN  
INN   USAN  
Official Name English
HP 549
Code English
isoxepac [INN]
Common Name English
ISOXEPAC [USAN]
Common Name English
OLOPATADINE RELATED COMPOUND C [USP IMPURITY]
Common Name English
P 720549
Code English
6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid
Systematic Name English
ARTIL
Brand Name English
HP-549
Code English
OLOPATADINE RELATED COMPOUND C
USP   USP-RS  
Common Name English
NSC-300907
Code English
OLOPATADINE RELATED COMPOUND C [USP-RS]
Common Name English
ISOXEPAC [MI]
Common Name English
DIBENZ(B,E)OXEPIN-2-ACETIC ACID, 6,11-DIHYDRO-11-OXO-
Common Name English
P-720549
Code English
Code System Code Type Description
RS_ITEM_NUM
1478436
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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MERCK INDEX
m6554
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID8057772
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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FDA UNII
2KH283Q0Z5
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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NCI_THESAURUS
C166578
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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MESH
C014904
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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DRUG CENTRAL
3310
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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EVMPD
SUB08343MIG
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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NSC
300907
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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INN
4246
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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PUBCHEM
41448
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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SMS_ID
100000082838
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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CAS
55453-87-7
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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ChEMBL
CHEMBL33211
Created by admin on Fri Dec 15 17:20:10 GMT 2023 , Edited by admin on Fri Dec 15 17:20:10 GMT 2023
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