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Details

Stereochemistry ACHIRAL
Molecular Formula C16H20ClN3
Molecular Weight 289.803
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLOROPYRAMINE

SMILES

CN(C)CCN(CC1=CC=C(Cl)C=C1)C2=NC=CC=C2

InChI

InChIKey=ICKFFNBDFNZJSX-UHFFFAOYSA-N
InChI=1S/C16H20ClN3/c1-19(2)11-12-20(16-5-3-4-10-18-16)13-14-6-8-15(17)9-7-14/h3-10H,11-13H2,1-2H3

HIDE SMILES / InChI

Description

Chloropyramine is an antagonist of H1 histamine receptors. It is indicated for the treatment of various forms of allergic reactions. Chloropyramine is a drug capable of (1) inhibiting the biochemical function of VEGFR-3 and FAK, (2) inhibiting proliferation of a diverse set of cancer cell types in vitro, and (3) reducing tumor growth in vivo.

CNS Activity

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ALLERGOSAN
Primary
PubMed

PubMed

TitleDatePubMed
Actions of endothelin and corticotropin releasing factor in the guinea-pig ileum: no evidence for an interaction with capsaicin-sensitive neurons.
2003 Aug
Severe anaphylactic reaction during the second infusion of infliximab in a patient with psoriatic arthritis.
2005 Sep-Oct
Characterization of histamine-induced relaxation in pre-contracted rat aorta.
2009 Apr
Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.
2009 Aug 13
[Discriminant function analysis in the assessment of laboratory test data in the correction of traditional therapy for mild icteric form of viral hepatitis B in children with food allergy].
2010 Jun
Patents

Sample Use Guides

In Vivo Use Guide
Composition: One ampoule of 2 ml contains 20 mg chloropyramine hydrochloride (10 mg/ml). One coated tablet contains 25 mg chloropyramine hydrochloride. 1 g of ointment (1%) contains 10 mg chloropyramine hydrochloride. 1 g of cream (1%) contains 10 mg chloropyramine hydrochloride. Dosage and administration: Parenteral administration: in severe allergic reactions 1-2 ampoules intramuscularly or intravenously. Oral administration: adults - 25 mg (1 tabl.) 3-4 times daily (up to 150 mg, if necessary); children over 5 years: 1 tablet, 2-3 times daily. External application: affected area should be treated once or several times a day by applying a thin layer of ointment or cream.
Route of Administration: intramuscularly, intravenously, oral, topical
In Vitro Use Guide
SKN-AS and SK-N-BE(2) neuroblastoma cells were treated with varying concentrations of chloropyramine hydrochloride (C4) for 24 h and cellular viability was measured. Both cell lines demonstrated a decrease in survival that was signifi-cant at 100 μM concentration. The calculated LC50 for C4 was similar in the two cell lines at 170 μM in the SK-N-AS cell line and 144 mM in the SK-N-BE(2) cell line.
Name Type Language
CHLOROPYRAMINE
INN   MI   WHO-DD  
INN  
Official Name English
CHLOROPYRAMINE [INN]
Common Name English
2-((P-CHLOROBENZYL)(2-DIMETHYLAMINOETHYL)AMINO)PYRIDINE
Common Name English
NSC-241038
Code English
CHLOROPYRAMINE [WHO-DD]
Common Name English
CHLOROPYRAMINE [MI]
Common Name English
HALOPYRAMINE
Common Name English
Classification Tree Code System Code
WHO-ATC R06AC03
Created by admin on Tue Mar 06 11:53:56 UTC 2018 , Edited by admin on Tue Mar 06 11:53:56 UTC 2018
WHO-VATC QD04AA09
Created by admin on Tue Mar 06 11:53:56 UTC 2018 , Edited by admin on Tue Mar 06 11:53:56 UTC 2018
WHO-VATC QR06AC53
Created by admin on Tue Mar 06 11:53:56 UTC 2018 , Edited by admin on Tue Mar 06 11:53:56 UTC 2018
WHO-VATC QR06AC03
Created by admin on Tue Mar 06 11:53:56 UTC 2018 , Edited by admin on Tue Mar 06 11:53:56 UTC 2018
WHO-ATC D04AA09
Created by admin on Tue Mar 06 11:53:56 UTC 2018 , Edited by admin on Tue Mar 06 11:53:56 UTC 2018
WHO-ATC R06AC53
Created by admin on Tue Mar 06 11:53:56 UTC 2018 , Edited by admin on Tue Mar 06 11:53:56 UTC 2018
Code System Code Type Description
MESH
C004664
Created by admin on Tue Mar 06 11:53:56 UTC 2018 , Edited by admin on Tue Mar 06 11:53:56 UTC 2018
PRIMARY
WIKIPEDIA
CHLOROPYRAMINE
Created by admin on Tue Mar 06 11:53:56 UTC 2018 , Edited by admin on Tue Mar 06 11:53:56 UTC 2018
PRIMARY
PUBCHEM
25295
Created by admin on Tue Mar 06 11:53:55 UTC 2018 , Edited by admin on Tue Mar 06 11:53:55 UTC 2018
PRIMARY SWITZERF
MERCK INDEX
M3434
Created by admin on Tue Mar 06 11:53:55 UTC 2018 , Edited by admin on Tue Mar 06 11:53:55 UTC 2018
PRIMARY Merck Index
RXCUI
20861
Created by admin on Tue Mar 06 11:53:55 UTC 2018 , Edited by admin on Tue Mar 06 11:53:55 UTC 2018
PRIMARY RxNorm
INN
179
Created by admin on Tue Mar 06 11:53:55 UTC 2018 , Edited by admin on Tue Mar 06 11:53:55 UTC 2018
PRIMARY
EVMPD
SUB06194MIG
Created by admin on Tue Mar 06 11:53:55 UTC 2018 , Edited by admin on Tue Mar 06 11:53:55 UTC 2018
PRIMARY
CAS
59-32-5
Created by admin on Tue Mar 06 11:53:56 UTC 2018 , Edited by admin on Tue Mar 06 11:53:56 UTC 2018
PRIMARY
EPA CompTox
59-32-5
Created by admin on Tue Mar 06 11:53:55 UTC 2018 , Edited by admin on Tue Mar 06 11:53:55 UTC 2018
PRIMARY
NCI_THESAURUS
C81130
Created by admin on Tue Mar 06 11:53:56 UTC 2018 , Edited by admin on Tue Mar 06 11:53:56 UTC 2018
PRIMARY
DRUG BANK
DB08800
Created by admin on Tue Mar 06 11:53:55 UTC 2018 , Edited by admin on Tue Mar 06 11:53:55 UTC 2018
PRIMARY
ChEMBL
CHEMBL1194287
Created by admin on Tue Mar 06 11:53:55 UTC 2018 , Edited by admin on Tue Mar 06 11:53:55 UTC 2018
PRIMARY
ECHA (EC/EINECS)
200-421-1
Created by admin on Tue Mar 06 11:53:55 UTC 2018 , Edited by admin on Tue Mar 06 11:53:55 UTC 2018
PRIMARY