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Details

Stereochemistry ACHIRAL
Molecular Formula C16H20ClN3
Molecular Weight 289.803
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLOROPYRAMINE

SMILES

CN(C)CCN(CC1=CC=C(Cl)C=C1)C2=CC=CC=N2

InChI

InChIKey=ICKFFNBDFNZJSX-UHFFFAOYSA-N
InChI=1S/C16H20ClN3/c1-19(2)11-12-20(16-5-3-4-10-18-16)13-14-6-8-15(17)9-7-14/h3-10H,11-13H2,1-2H3

HIDE SMILES / InChI
Chloropyramine is an antagonist of H1 histamine receptors. It is indicated for the treatment of various forms of allergic reactions. Chloropyramine is a drug capable of (1) inhibiting the biochemical function of VEGFR-3 and FAK, (2) inhibiting proliferation of a diverse set of cancer cell types in vitro, and (3) reducing tumor growth in vivo.

Originator

Curator's Comment: references retrieved from www.drugfuture.com/chemdata/chloropyramine.html # Wyeth Holdings Corp., Merck Sharp & Dohme Corp., Geigy

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
ALLERGOSAN

Approved Use

In the form of solution for injection, it is used in: acute allergic reactions related to urticaria treatment (due to foods, medicines, helminthes, etc.) and insect bite; in allergic reactions of general type (anaphylactic shock, serum disease, Quincke’s edema), when the product is used as a part of the complex therapy. In the form of tablets: for treatment of allergic rhinitis, conjunctivities, hay fever, drug and food allergy, allergic reactions after insect bite. In the form of ointment or cream it is used for treatment of allergic skin reactions.
PubMed

PubMed

TitleDatePubMed
Severe anaphylactic reaction during the second infusion of infliximab in a patient with psoriatic arthritis.
2005 Sep-Oct
Patents

Sample Use Guides

Composition: One ampoule of 2 ml contains 20 mg chloropyramine hydrochloride (10 mg/ml). One coated tablet contains 25 mg chloropyramine hydrochloride. 1 g of ointment (1%) contains 10 mg chloropyramine hydrochloride. 1 g of cream (1%) contains 10 mg chloropyramine hydrochloride. Dosage and administration: Parenteral administration: in severe allergic reactions 1-2 ampoules intramuscularly or intravenously. Oral administration: adults - 25 mg (1 tabl.) 3-4 times daily (up to 150 mg, if necessary); children over 5 years: 1 tablet, 2-3 times daily. External application: affected area should be treated once or several times a day by applying a thin layer of ointment or cream.
Route of Administration: Other
SKN-AS and SK-N-BE(2) neuroblastoma cells were treated with varying concentrations of chloropyramine hydrochloride (C4) for 24 h and cellular viability was measured. Both cell lines demonstrated a decrease in survival that was signifi-cant at 100 μM concentration. The calculated LC50 for C4 was similar in the two cell lines at 170 μM in the SK-N-AS cell line and 144 mM in the SK-N-BE(2) cell line.
Name Type Language
CHLOROPYRAMINE
INN   MI   WHO-DD  
INN  
Official Name English
chloropyramine [INN]
Common Name English
2-((P-CHLOROBENZYL)(2-DIMETHYLAMINOETHYL)AMINO)PYRIDINE
Common Name English
Chloropyramine [WHO-DD]
Common Name English
NSC-241038
Code English
CHLOROPYRAMINE [MI]
Common Name English
HALOPYRAMINE
Common Name English
Classification Tree Code System Code
WHO-ATC R06AC03
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
WHO-VATC QD04AA09
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
FDA ORPHAN DRUG 321110
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
NCI_THESAURUS C29578
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
WHO-VATC QR06AC53
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
WHO-VATC QR06AC03
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
WHO-ATC D04AA09
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
WHO-ATC R06AC53
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
Code System Code Type Description
MESH
C004664
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
WIKIPEDIA
CHLOROPYRAMINE
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
PUBCHEM
25295
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
NSC
241038
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
FDA UNII
2K3L8O9SOV
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
MERCK INDEX
m3434
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY Merck Index
RXCUI
20861
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY RxNorm
INN
179
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
EVMPD
SUB06194MIG
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
CAS
59-32-5
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
EPA CompTox
DTXSID50207729
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
NCI_THESAURUS
C81130
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
DRUG CENTRAL
606
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
DRUG BANK
DB08800
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
SMS_ID
100000081868
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
ChEMBL
CHEMBL1194287
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-421-1
Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023
PRIMARY