Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H20ClN3 |
Molecular Weight | 289.803 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCN(CC1=CC=C(Cl)C=C1)C2=CC=CC=N2
InChI
InChIKey=ICKFFNBDFNZJSX-UHFFFAOYSA-N
InChI=1S/C16H20ClN3/c1-19(2)11-12-20(16-5-3-4-10-18-16)13-14-6-8-15(17)9-7-14/h3-10H,11-13H2,1-2H3
Chloropyramine is an antagonist of H1 histamine receptors. It is indicated for the treatment of various forms of allergic reactions. Chloropyramine is a drug capable of (1) inhibiting the biochemical function of VEGFR-3 and FAK, (2) inhibiting proliferation of a diverse set of cancer cell types in vitro, and (3) reducing tumor growth in vivo.
CNS Activity
Originator
Sources: https://patents.google.com/patent/US2569314 | https://patents.google.com/patent/US2607778
Curator's Comment: references retrieved from www.drugfuture.com/chemdata/chloropyramine.html # Wyeth Holdings Corp., Merck Sharp & Dohme Corp., Geigy
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2695 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
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Primary | ALLERGOSAN Approved UseIn the form of solution for injection, it is used in: acute allergic reactions related to urticaria treatment (due to foods, medicines, helminthes, etc.) and insect bite; in allergic reactions of general type (anaphylactic shock, serum disease, Quincke’s edema), when the product is used as a part of the complex therapy. In the form of tablets: for treatment of allergic rhinitis, conjunctivities, hay fever, drug and food allergy, allergic reactions after insect bite. In the form of ointment or cream it is used for treatment of allergic skin reactions. |
Sample Use Guides
Composition:
One ampoule of 2 ml contains 20 mg chloropyramine hydrochloride (10 mg/ml).
One coated tablet contains 25 mg chloropyramine hydrochloride.
1 g of ointment (1%) contains 10 mg chloropyramine hydrochloride.
1 g of cream (1%) contains 10 mg chloropyramine hydrochloride.
Dosage and administration:
Parenteral administration: in severe allergic reactions 1-2 ampoules intramuscularly or intravenously.
Oral administration: adults - 25 mg (1 tabl.) 3-4 times daily (up to 150 mg, if necessary); children over 5 years: 1 tablet, 2-3 times daily.
External application: affected area should be treated once or several times a day by applying a thin layer of ointment or cream.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23868727
SKN-AS and SK-N-BE(2) neuroblastoma cells were treated with varying concentrations of chloropyramine hydrochloride (C4) for 24 h and cellular viability was measured. Both cell lines demonstrated a decrease in survival that was signifi-cant at 100 μM concentration. The calculated LC50 for C4 was similar in the two cell lines at 170 μM in the SK-N-AS cell line and 144 mM in the SK-N-BE(2) cell line.
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)