ALMINOPROFEN, (S)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C13H17NO2
Molecular Weight	219.2796
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H](C(O)=O)C1=CC=C(NCC(C)=C)C=C1

InChI

InChIKey=FPHLBGOJWPEVME-JTQLQIEISA-N

InChI=1S/C13H17NO2/c1-9(2)8-14-12-6-4-11(5-7-12)10(3)13(15)16/h4-7,10,14H,1,8H2,2-3H3,(H,15,16)/t10-/m0/s1

HIDE SMILES / InChI

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/9933032
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/2787705

Alminoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. It has anti-inflammatory properties different from the classical NSAID. Alminoprofen possesses both antiphospholipase A2 (PLA2) activity and anti-cycloxygenase (COX) activity.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase-2 196 Target ID: CHEMBL230 Sources: http://www.ncbi.nlm.nih.gov/pubmed/9933032	Inhibitor 8297
Secretory phospholipase A2, Homo sapiens 3 Target ID: Secretory phospholipase A2, Homo sapiens Sources: http://www.ncbi.nlm.nih.gov/pubmed/9933032	Inhibitor 8297
Cyclooxygenase-1 127 Target ID: CHEMBL221 Sources: http://www.genome.jp/dbget-bin/www_bget?D01513	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: http://www.ndrugs.com/?s=minalfen	Palliative		Approved 8429	Minalfen Approved Use Indications: inflammation, pain
Inflammation 102 Sources: http://www.ndrugs.com/?s=minalfen	Primary		Approved 8429	Minalfen Approved Use Indications: inflammation, pain

PubMed

Title	Date	PubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443

Patents

Sample Use Guides

In Vivo Use Guide

In rheumatoid arthritis and spondylosis deformans - 200 mg (three times a day) repeated dose for 5 days.

Route of Administration: Oral

In Vitro Use Guide

Alminoprofen (10(-6)-10(-4) M) inhibited dose-dependently the chemotaxis of leukocytes induced by chemotactic factors from guinea pig neutrophils stimulated with sodium urate crystals.

Name

Type

Language

ALMINOPROFEN, (S)-

Common Name

English

ALMINOPROFEN, (+)-

Common Name

English

BENZENEACETIC ACID, .ALPHA.-METHYL-4-((2-METHYL-2-PROPEN-1-YL)AMINO)-, (+)-

Systematic Name

English

BENZENEACETIC ACID, .ALPHA.-METHYL-4-((2-METHYL-2-PROPENYL)AMINO)-, (+)-

Common Name

English

BENZENEACETIC ACID, .ALPHA.-METHYL-4-((2-METHYL-2-PROPEN-1-YL)AMINO)-, (.ALPHA.S)-

Systematic Name

English

(+)-ALMINOPROFEN

Common Name

English

D-ALMINOPROFEN

Common Name

English

Code System Code Type Description

CAS

71589-39-4

Created by admin on Fri Dec 15 19:37:12 GMT 2023 , Edited by admin on Fri Dec 15 19:37:12 GMT 2023

PRIMARY

PUBCHEM

69305006

Created by admin on Fri Dec 15 19:37:12 GMT 2023 , Edited by admin on Fri Dec 15 19:37:12 GMT 2023

PRIMARY

EPA CompTox

DTXSID801167057

Created by admin on Fri Dec 15 19:37:12 GMT 2023 , Edited by admin on Fri Dec 15 19:37:12 GMT 2023

PRIMARY

FDA UNII

2K06B7892T

Created by admin on Fri Dec 15 19:37:12 GMT 2023 , Edited by admin on Fri Dec 15 19:37:12 GMT 2023

PRIMARY

SUBSTANCE RECORD


					2K06B7892T

ALMINOPROFEN, (S)-

Details

SMILES

InChI

DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/9933032Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/2787705

CNS Activity

Approval Year

Targets

Conditions

Approved Use

Approved Use

PubMed

Patents

Sample Use Guides

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/9933032
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/2787705