Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C42H38O20 |
Molecular Weight | 862.7391 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 12 / 12 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]1(C2=CC=CC(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C2C(=O)C4=C1C=C(C=C4O)C(O)=O)[C@]5([H])C6=C(C(=O)C7=C5C=C(C=C7O)C(O)=O)C(O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)=CC=C6
InChI
InChIKey=IPQVTOJGNYVQEO-KGFNBKMBSA-N
InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1
Sennoside A, derived from the traditional chinese medicine plant Rheum L., has being shown to be a dual HIV-1 inhibitor effective on HIV-1 replication. Sennoside A is a kind of irritant laxative. It is also used for colonoscopy preparation. It mildly inhibits bovine serum monoamine oxidase with IC50 of 17uM.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8234429
Curator's Comment: The active principle of Senna was first isolated and characterized by Stoll in 1941. The first two glycosides were identified and attributed to the anthraquinone family. These were found to be dimeric products of aloe emodin and/or rhein which were named sennoside A and sennoside B.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL247 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27765358 |
1.9 µM [IC50] | ||
Target ID: CHEMBL2111399 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2611933 |
17.0 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Senokot Approved UseSenokot, Senokot EXTRA and others is a natural medicine used to treat constipation. |
Sample Use Guides
Adults and children 12 years of age and over: The recommended starting dose is to use two 8.6 mg tablets by mouth once a day; maximum daily dose is 100 mg.
Children 6 to 12 years of age: The recommended starting dose is to use one 8.6 mg by mouth once a day; maximum daily dose 50 mg a day.
Children 2 to 6 years of age: The recommended dose is 4.3 to 17.2 mg per day.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27765358
Sennoside A and Sennoside B inhibited both HIV-1 RT-associated functions with IC50 values in the 2–5 uM range. Sennoside A inhibited the HIV-1 IN strand transfer activity with an IC50 value of 3.8 uM.
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SUB15223MIG
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201-339-9
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73111
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81-27-6
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112929
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DTXSID1023576
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)