SOFALCONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H30O6
Molecular Weight	450.5235
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)=CCOC1=CC=C(\C=C\C(=O)C2=CC=C(OCC=C(C)C)C=C2OCC(O)=O)C=C1

InChI

InChIKey=GFWRVVCDTLRWPK-KPKJPENVSA-N

InChI=1S/C27H30O6/c1-19(2)13-15-31-22-8-5-21(6-9-22)7-12-25(28)24-11-10-23(32-16-14-20(3)4)17-26(24)33-18-27(29)30/h5-14,17H,15-16,18H2,1-4H3,(H,29,30)/b12-7+

HIDE SMILES / InChI

Description
Sources: https://www.nipro-es-pharma.co.jp/product/di/files/tb/CSEF_tb_016701.html
Curator's Comment: Description was created based on several sources, including: http://www.taisho.co.jp/en/company/release/2004/04_0803-e.htm http://www.drugbank.ca/drugs/DB05197

Sofalcone is a mucosal protective agent that has been reported to inhibit growth of Helicobacter pylori. It is considered safe and effective for the treatment of gastritis and gastric ulcer. It is used in Japan. Adverse reactions are: liver dysfunction, jaundice, rash, constipation, dry mouth, heartburn.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin Synthesis and Regulation 6 Target ID: WP98 Sources: http://www.taisho.co.jp/en/company/release/2004/04_0803-e.htm	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Helicobacter pylori gastritis 3 Sources: https://www.nipro-es-pharma.co.jp/product/di/files/tb/CSEF_tb_016701.html	Primary		Approved 8429	Solon Approved Use It is used for the treatment of gastritis. Launch Date 1984
Peptic ulcer 72 Sources: https://www.nipro-es-pharma.co.jp/product/di/files/tb/CSEF_tb_016701.html	Primary		Approved 8429	Solon Approved Use It is used as peptic ulcer agent. Launch Date 1984

PubMed

Title	Date	PubMed
Preliminary study on a novel quadruple eradication therapy with a mucoprotective drug, sofalcone, for Helicobacter pylori infection.	1998	9872520

Patents

Sample Use Guides

In Vivo Use Guide

Adults take 100 mg of sofalcone 3 times a day.

Route of Administration: Oral

In Vitro Use Guide

MIC50 for Helicobacter pylori is 12.5 ug/ml

Name

Type

Language

SOFALCONE

Official Name

English

SOFALCONE [MI]

Common Name

English

SOLON

Brand Name

English

SOFALCONE [JAN]

Common Name

English

(5-((3-METHYL-2-BUTENYL)OXY)-2-(P-((3-METHYL-2-BUTENYL)OXY)CINNAMOYL)PHENOXY)ACETIC ACID

Systematic Name

English

sofalcone [INN]

Common Name

English

ACETIC ACID, 2-(5-((3-METHYL-2-BUTEN-1-YL)OXY)-2-((2E)-3-(4-((3-METHYL-2-BUTEN-1-YL)OXY)PHENYL)-1-OXO-2-PROPEN-1-YL)PHENOXY)-

Systematic Name

English

SU-88

Code

English

Sofalcone [WHO-DD]

Common Name

English

SOFALCONE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1745