DIETHAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H22N2S
Molecular Weight	298.446
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCN1C2=CC=CC=C2SC3=CC=CC=C13

InChI

InChIKey=LURMIKVZJSMXQE-UHFFFAOYSA-N

InChI=1S/C18H22N2S/c1-3-19(4-2)13-14-20-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)20/h5-12H,3-4,13-14H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.drugfuture.com/chemdata/diethazine.html | Martindale, W. (1967) Extra Pharmacopoeia; Incorporating "Squires Companion", page 162, retrieved from: https://books.google.ru/books?id=xH-4AAAAIAAJ | Lemke, T.L., Williams, D.A. (2008) Foye's Principles of Medicinal Chemistry, page 606, retrieved from: https://books.google.ru/books?id=R0W1ErpsQpkC | (1973) Acta Physiologica Polonica, page 885, retrieved from: https://books.google.ru/books?id=9O9JAQAAIAAJ

Diethazine is the antimuscarinic agent. It has actions similar to those of ethopropazine but it is more toxic. Diethazine is used for the palliative treatment of the parkinsonian syndrome. It is more useful in the treatment of Parkinson’s disease than in allergies. Blockade of single contractions observed in these experiments after administration of diethazine was independent of the frequency of stimulation of the nerve. This suggests that the drug acts directly on the postsynaptic receptor in the endplate.

Approval Year

PubMed

Title	Date	PubMed
Studies on antituberculotic action of some phenothiazine derivatives in vitro.	1977-12	24964

Name

Type

Language

DIETHAZINE [MI]

Preferred Name

English

DIETHAZINE

Official Name

English

10-(2-DIETHYLAMINOETHYL)PHENOTHIAZINE

Systematic Name

English

diethazine [INN]

Common Name

English

Diethazine [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66880